Mooloolabenes A−E, Norsesterterpenes from the Australian Sponge Hyattella intestinalis
Five new norsesterterpenes, mooloolabenes A−E (1−5), and the new sesterterpene mooloolaldehyde (6), related to the scalarane family of compounds, were isolated from an acetone extract of the Australian sponge Hyattella intestinalis. Structural elucidation, including relative stereochemical assignmen...
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| Veröffentlicht in: | Journal of natural products (Washington, D.C.) D.C.), 2006-11, Vol.69 (11), p.1587-1590 |
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| container_end_page | 1590 |
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| container_issue | 11 |
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| container_title | Journal of natural products (Washington, D.C.) |
| container_volume | 69 |
| creator | Somerville, Michael J Hooper, John N. A Garson, Mary J |
| description | Five new norsesterterpenes, mooloolabenes A−E (1−5), and the new sesterterpene mooloolaldehyde (6), related to the scalarane family of compounds, were isolated from an acetone extract of the Australian sponge Hyattella intestinalis. Structural elucidation, including relative stereochemical assignment, was based on spectroscopic analysis. All compounds tested showed cytotoxic activity against the P388 cell line. |
| doi_str_mv | 10.1021/np060244i |
| format | Article |
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All compounds tested showed cytotoxic activity against the P388 cell line.</description><identifier>ISSN: 0163-3864</identifier><identifier>EISSN: 1520-6025</identifier><identifier>DOI: 10.1021/np060244i</identifier><identifier>PMID: 17125226</identifier><identifier>CODEN: JNPRDF</identifier><language>eng</language><publisher>Washington, DC: American Chemical Society</publisher><subject>Animals ; Antineoplastic Agents - chemistry ; Antineoplastic Agents - isolation & purification ; Antineoplastic Agents - pharmacology ; Australia ; Biological and medical sciences ; Drug Screening Assays, Antitumor ; General pharmacology ; Hyattella intestinalis ; Leukemia P388 ; Medical sciences ; Mice ; Molecular Structure ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. 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A</creatorcontrib><creatorcontrib>Garson, Mary J</creatorcontrib><title>Mooloolabenes A−E, Norsesterterpenes from the Australian Sponge Hyattella intestinalis</title><title>Journal of natural products (Washington, D.C.)</title><addtitle>J. Nat. Prod</addtitle><description>Five new norsesterterpenes, mooloolabenes A−E (1−5), and the new sesterterpene mooloolaldehyde (6), related to the scalarane family of compounds, were isolated from an acetone extract of the Australian sponge Hyattella intestinalis. Structural elucidation, including relative stereochemical assignment, was based on spectroscopic analysis. All compounds tested showed cytotoxic activity against the P388 cell line.</description><subject>Animals</subject><subject>Antineoplastic Agents - chemistry</subject><subject>Antineoplastic Agents - isolation & purification</subject><subject>Antineoplastic Agents - pharmacology</subject><subject>Australia</subject><subject>Biological and medical sciences</subject><subject>Drug Screening Assays, Antitumor</subject><subject>General pharmacology</subject><subject>Hyattella intestinalis</subject><subject>Leukemia P388</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Molecular Structure</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. 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| identifier | ISSN: 0163-3864 |
| ispartof | Journal of natural products (Washington, D.C.), 2006-11, Vol.69 (11), p.1587-1590 |
| issn | 0163-3864 1520-6025 |
| language | eng |
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| source | MEDLINE; American Chemical Society Journals |
| subjects | Animals Antineoplastic Agents - chemistry Antineoplastic Agents - isolation & purification Antineoplastic Agents - pharmacology Australia Biological and medical sciences Drug Screening Assays, Antitumor General pharmacology Hyattella intestinalis Leukemia P388 Medical sciences Mice Molecular Structure Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Sesterterpenes Terpenes - chemistry Terpenes - isolation & purification Terpenes - pharmacology |
| title | Mooloolabenes A−E, Norsesterterpenes from the Australian Sponge Hyattella intestinalis |
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