Determination of echinacoside in rat serum by reversed-phase high-performance liquid chromatography with ultraviolet detection and its application to pharmacokinetics and bioavailability

A rapid and simple high-performance liquid chromatographic (HPLC) method has been developed and validated for the determination of echinacoside (ECH) in rat serum. After protein precipitation of serum sample with trichloroacetic acid, the supernatant was directly injected and analyzed on a C 18 Capc...

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Veröffentlicht in:	Journal of chromatography. B, Analytical technologies in the biomedical and life sciences Analytical technologies in the biomedical and life sciences, 2006-12, Vol.844 (2), p.308-313
Hauptverfasser:	Jia, Cunqin, Shi, Haiming, Wu, Xiangmei, Li, Yinzeng, Chen, Jingjing, Tu, Pengfei
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Analytical, structural and metabolic biochemistry Animals Bioavailability Biological and medical sciences Biological Availability Chromatography, High Pressure Liquid - methods Drug Stability Echinacoside Fundamental and applied biological sciences. Psychology General pharmacology Glycosides - blood Glycosides - pharmacokinetics HPLC Male Medical sciences Pharmacokinetics Pharmacology. Drug treatments Phenylethanoid glycoside Rats Rats, Sprague-Dawley Reproducibility of Results Spectrophotometry, Ultraviolet - methods
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