Survivin, a member of the inhibitors of apoptosis family, is Down-Regulated in breast carcinoma effusions
We analyzed the expression and prognostic role of inhibitors of apoptosis in breast carcinoma effusions. We used immunoblotting to analyze 22 effusions for XIAP, survivin, and livin expression. Based on immunoblotting results, 49 effusions and 46 corresponding solid tumors were immunostained for XIA...
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| Veröffentlicht in: | American journal of clinical pathology 2007-09, Vol.128 (3), p.389-397 |
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| creator | KLEINBERG, Lilach FLORENES, Vivi Ann NESLAND, Jahn M DAVIDSON, Ben |
| description | We analyzed the expression and prognostic role of inhibitors of apoptosis in breast carcinoma effusions. We used immunoblotting to analyze 22 effusions for XIAP, survivin, and livin expression. Based on immunoblotting results, 49 effusions and 46 corresponding solid tumors were immunostained for XIAP and survivin. Results were analyzed for association with anatomic site, clinicopathologic parameters, and survival. Immunoblotting showed frequent expression of XIAP and survivin and no expression of livin. Carcinoma cells in effusions showed lower survivin immunostaining compared with lymph node metastases (P = .008) and primary carcinomas (P = .041). Higher cytoplasmic survivin expression correlated with poor disease-free survival for patients with postchemotherapy effusions (P = .035). XIAP and survivin, but not livin, are frequently expressed in advanced breast carcinoma. Survivin is down-regulated in effusions compared with solid tumors, possibly in relation to the different cellular economy at this anatomic site. Survivin expression may predict disease-free survival for patients with postchemotherapy effusions. |
| doi_str_mv | 10.1309/e899bg1282m5d505 |
| format | Article |
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We used immunoblotting to analyze 22 effusions for XIAP, survivin, and livin expression. Based on immunoblotting results, 49 effusions and 46 corresponding solid tumors were immunostained for XIAP and survivin. Results were analyzed for association with anatomic site, clinicopathologic parameters, and survival. Immunoblotting showed frequent expression of XIAP and survivin and no expression of livin. Carcinoma cells in effusions showed lower survivin immunostaining compared with lymph node metastases (P = .008) and primary carcinomas (P = .041). Higher cytoplasmic survivin expression correlated with poor disease-free survival for patients with postchemotherapy effusions (P = .035). XIAP and survivin, but not livin, are frequently expressed in advanced breast carcinoma. Survivin is down-regulated in effusions compared with solid tumors, possibly in relation to the different cellular economy at this anatomic site. Survivin expression may predict disease-free survival for patients with postchemotherapy effusions.</description><identifier>ISSN: 0002-9173</identifier><identifier>EISSN: 1943-7722</identifier><identifier>DOI: 10.1309/e899bg1282m5d505</identifier><identifier>PMID: 17709312</identifier><identifier>CODEN: AJCPAI</identifier><language>eng</language><publisher>Chicago, IL: American Society of Clinical Pathologists</publisher><subject>Adaptor Proteins, Signal Transducing - metabolism ; Adult ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Biomarkers, Tumor - analysis ; Breast Neoplasms - metabolism ; Carcinoma - metabolism ; Disease-Free Survival ; Down-Regulation ; Female ; Gynecology. Andrology. Obstetrics ; Humans ; Inhibitor of Apoptosis Proteins - metabolism ; Investigative techniques, diagnostic techniques (general aspects) ; Ki-67 Antigen - metabolism ; Mammary gland diseases ; Medical sciences ; Microtubule-Associated Proteins - metabolism ; Middle Aged ; Neoplasm Metastasis ; Neoplasm Proteins - metabolism ; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques ; Pleural Effusion, Malignant - metabolism ; Prognosis ; Tumors ; X-Linked Inhibitor of Apoptosis Protein - metabolism</subject><ispartof>American journal of clinical pathology, 2007-09, Vol.128 (3), p.389-397</ispartof><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c435t-ea0c753a5aa28b71a44e16f6c654782a8ad62e4f9742a2935f3d9969f7d98cc63</citedby><cites>FETCH-LOGICAL-c435t-ea0c753a5aa28b71a44e16f6c654782a8ad62e4f9742a2935f3d9969f7d98cc63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27929,27930</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19010970$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17709312$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>KLEINBERG, Lilach</creatorcontrib><creatorcontrib>FLORENES, Vivi Ann</creatorcontrib><creatorcontrib>NESLAND, Jahn M</creatorcontrib><creatorcontrib>DAVIDSON, Ben</creatorcontrib><title>Survivin, a member of the inhibitors of apoptosis family, is Down-Regulated in breast carcinoma effusions</title><title>American journal of clinical pathology</title><addtitle>Am J Clin Pathol</addtitle><description>We analyzed the expression and prognostic role of inhibitors of apoptosis in breast carcinoma effusions. We used immunoblotting to analyze 22 effusions for XIAP, survivin, and livin expression. Based on immunoblotting results, 49 effusions and 46 corresponding solid tumors were immunostained for XIAP and survivin. Results were analyzed for association with anatomic site, clinicopathologic parameters, and survival. Immunoblotting showed frequent expression of XIAP and survivin and no expression of livin. Carcinoma cells in effusions showed lower survivin immunostaining compared with lymph node metastases (P = .008) and primary carcinomas (P = .041). Higher cytoplasmic survivin expression correlated with poor disease-free survival for patients with postchemotherapy effusions (P = .035). XIAP and survivin, but not livin, are frequently expressed in advanced breast carcinoma. Survivin is down-regulated in effusions compared with solid tumors, possibly in relation to the different cellular economy at this anatomic site. Survivin expression may predict disease-free survival for patients with postchemotherapy effusions.</description><subject>Adaptor Proteins, Signal Transducing - metabolism</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Biomarkers, Tumor - analysis</subject><subject>Breast Neoplasms - metabolism</subject><subject>Carcinoma - metabolism</subject><subject>Disease-Free Survival</subject><subject>Down-Regulation</subject><subject>Female</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Inhibitor of Apoptosis Proteins - metabolism</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Ki-67 Antigen - metabolism</subject><subject>Mammary gland diseases</subject><subject>Medical sciences</subject><subject>Microtubule-Associated Proteins - metabolism</subject><subject>Middle Aged</subject><subject>Neoplasm Metastasis</subject><subject>Neoplasm Proteins - metabolism</subject><subject>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</subject><subject>Pleural Effusion, Malignant - metabolism</subject><subject>Prognosis</subject><subject>Tumors</subject><subject>X-Linked Inhibitor of Apoptosis Protein - metabolism</subject><issn>0002-9173</issn><issn>1943-7722</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkEtLxDAUhYMoOo7uXUk2urKaR9M0S98KI4KPdblNbzTSNmPSKv57Ozjg6h4u3zmLj5ADzk65ZOYMS2PqNy5K0alGMbVBZtzkMtNaiE0yY4yJzHAtd8huSh-MTSTLt8kO15oZycWM-Ocxfvkv359QoB12NUYaHB3ekfr-3dd-CDGtPrAMyyEkn6iDzrc_J3SKV-G7z57wbWxhwGZq0DoipIFaiNb3oQOKzo3Jhz7tkS0HbcL99Z2T15vrl8u7bPF4e395vshsLtWQITCrlQQFIMpac8hz5IUrbKFyXQoooSkE5s7oXIAwUjnZGFMYpxtTWlvIOTn-213G8DliGqrOJ4ttCz2GMVVFyUtVSD2B7A-0MaQU0VXL6DuIPxVn1UpvdT3pvbhd6X1QV5PeqXK43h7rDpv_wtrnBBytAUgWWhehtz79c4ZxZjSTvzySg6Q</recordid><startdate>20070901</startdate><enddate>20070901</enddate><creator>KLEINBERG, Lilach</creator><creator>FLORENES, Vivi Ann</creator><creator>NESLAND, Jahn M</creator><creator>DAVIDSON, Ben</creator><general>American Society of Clinical Pathologists</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20070901</creationdate><title>Survivin, a member of the inhibitors of apoptosis family, is Down-Regulated in breast carcinoma effusions</title><author>KLEINBERG, Lilach ; FLORENES, Vivi Ann ; NESLAND, Jahn M ; DAVIDSON, Ben</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c435t-ea0c753a5aa28b71a44e16f6c654782a8ad62e4f9742a2935f3d9969f7d98cc63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adaptor Proteins, Signal Transducing - metabolism</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Biomarkers, Tumor - analysis</topic><topic>Breast Neoplasms - metabolism</topic><topic>Carcinoma - metabolism</topic><topic>Disease-Free Survival</topic><topic>Down-Regulation</topic><topic>Female</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Inhibitor of Apoptosis Proteins - metabolism</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Ki-67 Antigen - metabolism</topic><topic>Mammary gland diseases</topic><topic>Medical sciences</topic><topic>Microtubule-Associated Proteins - metabolism</topic><topic>Middle Aged</topic><topic>Neoplasm Metastasis</topic><topic>Neoplasm Proteins - metabolism</topic><topic>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</topic><topic>Pleural Effusion, Malignant - metabolism</topic><topic>Prognosis</topic><topic>Tumors</topic><topic>X-Linked Inhibitor of Apoptosis Protein - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>KLEINBERG, Lilach</creatorcontrib><creatorcontrib>FLORENES, Vivi Ann</creatorcontrib><creatorcontrib>NESLAND, Jahn M</creatorcontrib><creatorcontrib>DAVIDSON, Ben</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of clinical pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>KLEINBERG, Lilach</au><au>FLORENES, Vivi Ann</au><au>NESLAND, Jahn M</au><au>DAVIDSON, Ben</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Survivin, a member of the inhibitors of apoptosis family, is Down-Regulated in breast carcinoma effusions</atitle><jtitle>American journal of clinical pathology</jtitle><addtitle>Am J Clin Pathol</addtitle><date>2007-09-01</date><risdate>2007</risdate><volume>128</volume><issue>3</issue><spage>389</spage><epage>397</epage><pages>389-397</pages><issn>0002-9173</issn><eissn>1943-7722</eissn><coden>AJCPAI</coden><abstract>We analyzed the expression and prognostic role of inhibitors of apoptosis in breast carcinoma effusions. We used immunoblotting to analyze 22 effusions for XIAP, survivin, and livin expression. Based on immunoblotting results, 49 effusions and 46 corresponding solid tumors were immunostained for XIAP and survivin. Results were analyzed for association with anatomic site, clinicopathologic parameters, and survival. Immunoblotting showed frequent expression of XIAP and survivin and no expression of livin. Carcinoma cells in effusions showed lower survivin immunostaining compared with lymph node metastases (P = .008) and primary carcinomas (P = .041). Higher cytoplasmic survivin expression correlated with poor disease-free survival for patients with postchemotherapy effusions (P = .035). XIAP and survivin, but not livin, are frequently expressed in advanced breast carcinoma. Survivin is down-regulated in effusions compared with solid tumors, possibly in relation to the different cellular economy at this anatomic site. Survivin expression may predict disease-free survival for patients with postchemotherapy effusions.</abstract><cop>Chicago, IL</cop><pub>American Society of Clinical Pathologists</pub><pmid>17709312</pmid><doi>10.1309/e899bg1282m5d505</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adaptor Proteins, Signal Transducing - metabolism Adult Aged Aged, 80 and over Biological and medical sciences Biomarkers, Tumor - analysis Breast Neoplasms - metabolism Carcinoma - metabolism Disease-Free Survival Down-Regulation Female Gynecology. Andrology. Obstetrics Humans Inhibitor of Apoptosis Proteins - metabolism Investigative techniques, diagnostic techniques (general aspects) Ki-67 Antigen - metabolism Mammary gland diseases Medical sciences Microtubule-Associated Proteins - metabolism Middle Aged Neoplasm Metastasis Neoplasm Proteins - metabolism Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Pleural Effusion, Malignant - metabolism Prognosis Tumors X-Linked Inhibitor of Apoptosis Protein - metabolism |
| title | Survivin, a member of the inhibitors of apoptosis family, is Down-Regulated in breast carcinoma effusions |
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