Striking differences of action of lisuride stereoisomers at histamine H1 receptors

This study has characterised the pharmacological profile of some dopaminergic agents of the ergoline family including the antiparkinsonian drug 8S-lisuride at native guinea pig histamine H(1) receptors and recombinant human and guinea pig H(1) receptors. We used segments of guinea pig ileum to study...

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Veröffentlicht in:	Naunyn-Schmiedeberg's archives of pharmacology 2006-12, Vol.374 (3), p.215-222
Hauptverfasser:	Pertz, Heinz H, Görnemann, Tilo, Schurad, Björn, Seifert, Roland, Strasser, Andrea
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antiparkinson Agents - pharmacology Cell Membrane - drug effects Cell Membrane - metabolism Dopamine - physiology Dopamine Agonists - pharmacology GTP Phosphohydrolases - metabolism GTP-Binding Protein alpha Subunits, Gq-G11 - metabolism Guinea Pigs Humans Ileum - drug effects Ileum - metabolism Insecta - cytology Lisuride - pharmacology Male Muscle Contraction - drug effects Parkinson Disease - drug therapy Pyrilamine Receptors, Histamine H1 - drug effects Receptors, Histamine H1 - metabolism RGS Proteins Species Specificity Stereoisomerism
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