Angiotensin II receptor blocker inhibits abnormal accumulation of advanced glycation end products and retinal damage in a rat model of type 2 diabetes

The effects of an angiotensin II receptor blocker (ARB) on the accumulation of one of advanced glycation end products (AGEs), pentosidine, expression of vascular endothelial growth factor (VEGF) and retinal function were investigated in Spontaneously Diabetic Torii (SDT) rats. Candesartan, an ARB, w...

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Veröffentlicht in:	Experimental eye research 2007-09, Vol.85 (3), p.406-412
Hauptverfasser:	Sugiyama, Tetsuya, Okuno, Takashi, Fukuhara, Masayuki, Oku, Hidehiro, Ikeda, Tsunehiko, Obayashi, Hiroshi, Ohta, Mitsuhiro, Fukui, Michiaki, Hasegawa, Goji, Nakamura, Naoto
Format:	Artikel
Sprache:	eng
Schlagworte:	advanced glycation end products angiotensin II receptor blocker Angiotensin II Type 1 Receptor Blockers - therapeutic use Angiotensin Receptor Antagonists Animals Arginine - analogs & derivatives Arginine - metabolism Benzimidazoles - therapeutic use Biphenyl Compounds - therapeutic use Blood Glucose - metabolism Chromatography, High Pressure Liquid - methods Diabetes Mellitus, Type 2 - complications Diabetes Mellitus, Type 2 - metabolism Diabetes Mellitus, Type 2 - pathology Diabetes Mellitus, Type 2 - physiopathology Diabetic Retinopathy - pathology Diabetic Retinopathy - physiopathology Diabetic Retinopathy - prevention & control Drug Evaluation, Preclinical electroretinogram Electroretinography Gene Expression Regulation - drug effects Glycation End Products, Advanced - metabolism high-performance liquid chromatography immunohistochemistry Lysine - analogs & derivatives Lysine - metabolism Male Rats Rats, Sprague-Dawley real-time reverse transcription-PCR Retina - drug effects Retina - physiopathology Reverse Transcriptase Polymerase Chain Reaction - methods spontaneously diabetic torii rats Tetrazoles - therapeutic use vascular endothelial growth factor Vascular Endothelial Growth Factor A - biosynthesis Vascular Endothelial Growth Factor A - genetics
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