DOTA-PESIN, a DOTA-conjugated bombesin derivative designed for the imaging and targeted radionuclide treatment of bombesin receptor-positive tumours

We aimed at designing and developing a novel bombesin analogue, DOTA-PEG(4)-BN(7-14) (DOTA-PESIN), with the goal of labelling it with (67/68)Ga and (177)Lu for diagnosis and radionuclide therapy of prostate and other human cancers overexpressing bombesin receptors. The 8-amino acid peptide bombesin...

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Veröffentlicht in:	European journal of nuclear medicine and molecular imaging 2007-08, Vol.34 (8), p.1198-1208
Hauptverfasser:	Zhang, Hanwen, Schuhmacher, Jochen, Waser, Beatrice, Wild, Damian, Eisenhut, Michael, Reubi, Jean Claude, Maecke, Helmut R
Format:	Artikel
Sprache:	eng
Schlagworte:	Affinity Amino acids Animals Bombesin Bombesin - analogs & derivatives Bombesin - chemistry Cell Line, Tumor Efflux Gallium Radioisotopes Gene Expression Regulation, Neoplastic Heterocyclic Compounds, 1-Ring - chemistry Human performance Humans Injection Kidneys Labeling Lutetium Lutetium isotopes Male Medical imaging Mice Mouse devices Neoplasm Transplantation Neuromedin Nuclear medicine Organs Pancreas Peptides Positron emission Positron emission tomography Prostate Prostate cancer Prostatic Neoplasms - diagnostic imaging Prostatic Neoplasms - metabolism Radiation therapy Radioisotopes Radionuclide Imaging - methods Receptors Receptors, Bombesin - biosynthesis Salts Single photon emission computed tomography Tomography Tumors Xenografts
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