A polymorphism in the AMH type II receptor gene is associated with age at menopause in interaction with parity
BACKGROUND Anti-Müllerian hormone (AMH) inhibits primordial follicle recruitment in the mouse ovary. We hypothesize that in women AMH signaling also regulates the usage of the primordial follicle pool and hence influences the onset of menopause. Since age at menopause has a strong genetic component,...
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| Veröffentlicht in: | Human reproduction (Oxford) 2007-09, Vol.22 (9), p.2382-2388 |
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| creator | Kevenaar, Marlies E. Themmen, Axel P.N. Rivadeneira, Fernando Uitterlinden, André G. Laven, Joop S.E. van Schoor, Natasja M. Lips, Paul Pols, Huibert A.P. Visser, Jenny A. |
| description | BACKGROUND Anti-Müllerian hormone (AMH) inhibits primordial follicle recruitment in the mouse ovary. We hypothesize that in women AMH signaling also regulates the usage of the primordial follicle pool and hence influences the onset of menopause. Since age at menopause has a strong genetic component, we investigated the role of AMH signaling using a candidate gene approach. METHODS In two large population-based cohorts of Dutch post-menopausal women (n = 2381 and n = 248), we examined the association between two polymorphisms, one in the AMH gene and one in the AMH type II receptor (AMHR2) gene, and natural age at menopause. RESULTS The AMH Ile49Ser polymorphism (rs10407022) was not associated with age at menopause in either cohort. In the Rotterdam cohort, the AMHR2 −482 A > G polymorphism (rs2002555) was associated with age at menopause in interaction with the number of offspring (P = 0.001). Nulliparous women homozygous for the G-allele entered menopause 2.6 years earlier compared with nulliparous women homozygous for the A-allele (P = 0.005). In the LASA cohort, women with the G/G genotype tended to enter menopause 2.8 years earlier compared with the A/A genotype (P = 0.063). CONCLUSIONS The observed association of the AMHR2 −482 A > G polymorphism with natural age at menopause suggests a role for AMH signaling in the usage of the primordial follicle pool in women. |
| doi_str_mv | 10.1093/humrep/dem176 |
| format | Article |
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We hypothesize that in women AMH signaling also regulates the usage of the primordial follicle pool and hence influences the onset of menopause. Since age at menopause has a strong genetic component, we investigated the role of AMH signaling using a candidate gene approach. METHODS In two large population-based cohorts of Dutch post-menopausal women (n = 2381 and n = 248), we examined the association between two polymorphisms, one in the AMH gene and one in the AMH type II receptor (AMHR2) gene, and natural age at menopause. RESULTS The AMH Ile49Ser polymorphism (rs10407022) was not associated with age at menopause in either cohort. In the Rotterdam cohort, the AMHR2 −482 A > G polymorphism (rs2002555) was associated with age at menopause in interaction with the number of offspring (P = 0.001). Nulliparous women homozygous for the G-allele entered menopause 2.6 years earlier compared with nulliparous women homozygous for the A-allele (P = 0.005). In the LASA cohort, women with the G/G genotype tended to enter menopause 2.8 years earlier compared with the A/A genotype (P = 0.063). CONCLUSIONS The observed association of the AMHR2 −482 A > G polymorphism with natural age at menopause suggests a role for AMH signaling in the usage of the primordial follicle pool in women.</description><identifier>ISSN: 0268-1161</identifier><identifier>EISSN: 1460-2350</identifier><identifier>DOI: 10.1093/humrep/dem176</identifier><identifier>PMID: 17636279</identifier><identifier>CODEN: HUREEE</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Age Factors ; Age of Onset ; Aged ; Aged, 80 and over ; anti-Müllerian hormone ; Biological and medical sciences ; Cohort Studies ; Female ; follicle recruitment ; Genotype ; Gynecology. Andrology. Obstetrics ; Humans ; Isoleucine - chemistry ; Isoleucine - genetics ; Medical sciences ; menopause ; Menopause - genetics ; Middle Aged ; Netherlands ; polymorphism ; Receptors, Peptide - genetics ; Receptors, Transforming Growth Factor beta - genetics ; Serine - chemistry ; Serine - genetics</subject><ispartof>Human reproduction (Oxford), 2007-09, Vol.22 (9), p.2382-2388</ispartof><rights>The Author 2007. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org 2007</rights><rights>2007 INIST-CNRS</rights><rights>The Author 2007. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c489t-4ac00851942c7b3f8fd1532f38652a60191c3e080935c46ff7968dd595cb28e63</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1578,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19070758$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17636279$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kevenaar, Marlies E.</creatorcontrib><creatorcontrib>Themmen, Axel P.N.</creatorcontrib><creatorcontrib>Rivadeneira, Fernando</creatorcontrib><creatorcontrib>Uitterlinden, André G.</creatorcontrib><creatorcontrib>Laven, Joop S.E.</creatorcontrib><creatorcontrib>van Schoor, Natasja M.</creatorcontrib><creatorcontrib>Lips, Paul</creatorcontrib><creatorcontrib>Pols, Huibert A.P.</creatorcontrib><creatorcontrib>Visser, Jenny A.</creatorcontrib><title>A polymorphism in the AMH type II receptor gene is associated with age at menopause in interaction with parity</title><title>Human reproduction (Oxford)</title><addtitle>Hum Reprod</addtitle><description>BACKGROUND Anti-Müllerian hormone (AMH) inhibits primordial follicle recruitment in the mouse ovary. We hypothesize that in women AMH signaling also regulates the usage of the primordial follicle pool and hence influences the onset of menopause. Since age at menopause has a strong genetic component, we investigated the role of AMH signaling using a candidate gene approach. METHODS In two large population-based cohorts of Dutch post-menopausal women (n = 2381 and n = 248), we examined the association between two polymorphisms, one in the AMH gene and one in the AMH type II receptor (AMHR2) gene, and natural age at menopause. RESULTS The AMH Ile49Ser polymorphism (rs10407022) was not associated with age at menopause in either cohort. In the Rotterdam cohort, the AMHR2 −482 A > G polymorphism (rs2002555) was associated with age at menopause in interaction with the number of offspring (P = 0.001). Nulliparous women homozygous for the G-allele entered menopause 2.6 years earlier compared with nulliparous women homozygous for the A-allele (P = 0.005). In the LASA cohort, women with the G/G genotype tended to enter menopause 2.8 years earlier compared with the A/A genotype (P = 0.063). CONCLUSIONS The observed association of the AMHR2 −482 A > G polymorphism with natural age at menopause suggests a role for AMH signaling in the usage of the primordial follicle pool in women.</description><subject>Age Factors</subject><subject>Age of Onset</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>anti-Müllerian hormone</subject><subject>Biological and medical sciences</subject><subject>Cohort Studies</subject><subject>Female</subject><subject>follicle recruitment</subject><subject>Genotype</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Isoleucine - chemistry</subject><subject>Isoleucine - genetics</subject><subject>Medical sciences</subject><subject>menopause</subject><subject>Menopause - genetics</subject><subject>Middle Aged</subject><subject>Netherlands</subject><subject>polymorphism</subject><subject>Receptors, Peptide - genetics</subject><subject>Receptors, Transforming Growth Factor beta - genetics</subject><subject>Serine - chemistry</subject><subject>Serine - genetics</subject><issn>0268-1161</issn><issn>1460-2350</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0c1rFDEYBvBBFLutHr1KEBQvY_MxySTHpWp3oSKIX3gJ2cw73dSZSZpkqPvfO8sMFrz0lBx-PMn7PkXxguB3BCt2vh_7COG8gZ7U4lGxIpXAJWUcPy5WmApZEiLISXGa0g3G01WKp8XJRJmgtVoVwxoF3x16H8PepR65AeU9oPWnDcqHAGi7RREshOwjuoYBkEvIpOStMxkadOfyHplrQCajHgYfzJjgGOKGDNHY7Pwwo2Ciy4dnxZPWdAmeL-dZ8e3jh68Xm_Lq8-X2Yn1V2kqqXFbGYiw5URW19Y61sm0IZ7RlUnBqBCaKWAZYTgvgthJtWyshm4YrbndUgmBnxZs5N0R_O0LKunfJQteZAfyYtJBEclzJByElmDIlyQRf_Qdv_BiHaYjJEIUppkdUzshGn1KEVofoehMPmmB9rEvPdem5rsm_XELHXQ_NvV76mcDrBZhkTddGM1iX7p3CNa75cYy3s_NjePDN5Y8uZfjzD5v4W4ua1Vxvfv7Sl-o9-fFdfNGM_QWU1rs_</recordid><startdate>20070901</startdate><enddate>20070901</enddate><creator>Kevenaar, Marlies E.</creator><creator>Themmen, Axel P.N.</creator><creator>Rivadeneira, Fernando</creator><creator>Uitterlinden, André G.</creator><creator>Laven, Joop S.E.</creator><creator>van Schoor, Natasja M.</creator><creator>Lips, Paul</creator><creator>Pols, Huibert A.P.</creator><creator>Visser, Jenny A.</creator><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20070901</creationdate><title>A polymorphism in the AMH type II receptor gene is associated with age at menopause in interaction with parity</title><author>Kevenaar, Marlies E. ; Themmen, Axel P.N. ; Rivadeneira, Fernando ; Uitterlinden, André G. ; Laven, Joop S.E. ; van Schoor, Natasja M. ; Lips, Paul ; Pols, Huibert A.P. ; Visser, Jenny A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c489t-4ac00851942c7b3f8fd1532f38652a60191c3e080935c46ff7968dd595cb28e63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Age Factors</topic><topic>Age of Onset</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>anti-Müllerian hormone</topic><topic>Biological and medical sciences</topic><topic>Cohort Studies</topic><topic>Female</topic><topic>follicle recruitment</topic><topic>Genotype</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Isoleucine - chemistry</topic><topic>Isoleucine - genetics</topic><topic>Medical sciences</topic><topic>menopause</topic><topic>Menopause - genetics</topic><topic>Middle Aged</topic><topic>Netherlands</topic><topic>polymorphism</topic><topic>Receptors, Peptide - genetics</topic><topic>Receptors, Transforming Growth Factor beta - genetics</topic><topic>Serine - chemistry</topic><topic>Serine - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kevenaar, Marlies E.</creatorcontrib><creatorcontrib>Themmen, Axel P.N.</creatorcontrib><creatorcontrib>Rivadeneira, Fernando</creatorcontrib><creatorcontrib>Uitterlinden, André G.</creatorcontrib><creatorcontrib>Laven, Joop S.E.</creatorcontrib><creatorcontrib>van Schoor, Natasja M.</creatorcontrib><creatorcontrib>Lips, Paul</creatorcontrib><creatorcontrib>Pols, Huibert A.P.</creatorcontrib><creatorcontrib>Visser, Jenny A.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Human reproduction (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kevenaar, Marlies E.</au><au>Themmen, Axel P.N.</au><au>Rivadeneira, Fernando</au><au>Uitterlinden, André G.</au><au>Laven, Joop S.E.</au><au>van Schoor, Natasja M.</au><au>Lips, Paul</au><au>Pols, Huibert A.P.</au><au>Visser, Jenny A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A polymorphism in the AMH type II receptor gene is associated with age at menopause in interaction with parity</atitle><jtitle>Human reproduction (Oxford)</jtitle><addtitle>Hum Reprod</addtitle><date>2007-09-01</date><risdate>2007</risdate><volume>22</volume><issue>9</issue><spage>2382</spage><epage>2388</epage><pages>2382-2388</pages><issn>0268-1161</issn><eissn>1460-2350</eissn><coden>HUREEE</coden><abstract>BACKGROUND Anti-Müllerian hormone (AMH) inhibits primordial follicle recruitment in the mouse ovary. We hypothesize that in women AMH signaling also regulates the usage of the primordial follicle pool and hence influences the onset of menopause. Since age at menopause has a strong genetic component, we investigated the role of AMH signaling using a candidate gene approach. METHODS In two large population-based cohorts of Dutch post-menopausal women (n = 2381 and n = 248), we examined the association between two polymorphisms, one in the AMH gene and one in the AMH type II receptor (AMHR2) gene, and natural age at menopause. RESULTS The AMH Ile49Ser polymorphism (rs10407022) was not associated with age at menopause in either cohort. In the Rotterdam cohort, the AMHR2 −482 A > G polymorphism (rs2002555) was associated with age at menopause in interaction with the number of offspring (P = 0.001). Nulliparous women homozygous for the G-allele entered menopause 2.6 years earlier compared with nulliparous women homozygous for the A-allele (P = 0.005). In the LASA cohort, women with the G/G genotype tended to enter menopause 2.8 years earlier compared with the A/A genotype (P = 0.063). CONCLUSIONS The observed association of the AMHR2 −482 A > G polymorphism with natural age at menopause suggests a role for AMH signaling in the usage of the primordial follicle pool in women.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>17636279</pmid><doi>10.1093/humrep/dem176</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Age Factors Age of Onset Aged Aged, 80 and over anti-Müllerian hormone Biological and medical sciences Cohort Studies Female follicle recruitment Genotype Gynecology. Andrology. Obstetrics Humans Isoleucine - chemistry Isoleucine - genetics Medical sciences menopause Menopause - genetics Middle Aged Netherlands polymorphism Receptors, Peptide - genetics Receptors, Transforming Growth Factor beta - genetics Serine - chemistry Serine - genetics |
| title | A polymorphism in the AMH type II receptor gene is associated with age at menopause in interaction with parity |
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