Genetic and evolutional mechanisms explain associated malformations – a ‘G–E–M’ concept

Summary During the process of evolution, segmented structures like heart and kidneys appeared earlier than vertebral column. Single piece notochord was transformed into segmented vertebral column. Ribs followed the segmented vertebral column but preceded the fore limbs in evolution. Segmentation is...

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Veröffentlicht in:	Medical hypotheses 2007, Vol.69 (4), p.879-883
Hauptverfasser:	Gokhale, Sanjay G, Gokhale, Sankalp
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomechanical Phenomena Congenital Abnormalities - embryology Congenital Abnormalities - etiology Congenital Abnormalities - genetics Embryonic Development - genetics Evolution, Molecular Female Humans Internal Medicine Kidney - embryology Models, Genetic Pregnancy Ribs - abnormalities Ribs - embryology
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