Meta-analysis of APOE genotype and subarachnoid hemorrhage : Clinical outcome and delayed ischemia
Emerging evidence suggests that the APOE4 allele may increase the risk of a negative outcome in patients with aneurysmal subarachnoid hemorrhage (SAH), but the results are conflicting. A genetic variable predicting the individual clinical course is currently lacking. To examine the association betwe...
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| Veröffentlicht in: | Neurology 2007-08, Vol.69 (8), p.766-775 |
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| creator | LANTERNA, L. A RUIGROK, Y ALEXANDER, S TANG, J BIROLI, F DUNN, L. T POON, W. S |
| description | Emerging evidence suggests that the APOE4 allele may increase the risk of a negative outcome in patients with aneurysmal subarachnoid hemorrhage (SAH), but the results are conflicting. A genetic variable predicting the individual clinical course is currently lacking.
To examine the association between the APOE4 allele and a negative outcome. A secondary objective was to investigate the association between the APOE4 allele and delayed ischemia, a major complication of SAH.
We searched MEDLINE, EMBASE, the Cochrane Library, CINHAL, LILACS, and www.google.it through March 2006. We hand-searched journals, international conference proceedings, and reference lists of retrieved articles. Individual patient data were requested from the corresponding authors of the original articles. Information on study design, participant characteristics, clinical outcome, delayed ischemia, and confounder distribution were independently abstracted by two investigators.
We included eight observational studies (696 patients for the clinical outcome and 600 for the delayed ischemia analyses). The corresponding authors of all the retrieved publications but one gave their original data. Summary odds ratios (ORs) were calculated by means of the random-effect model. The risk of a negative outcome (OR = 2.558; 95% CI 1.610 to 4.065) and delayed ischemia (OR = 2.044; 95% CI 1.269 to 3.291) were increased in the E4 carriers.
In patients with subarachnoid hemorrhage, the expression of the E4 allele is associated with a higher risk of a negative outcome and delayed ischemia. |
| doi_str_mv | 10.1212/01.wnl.0000267640.03300.6b |
| format | Article |
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To examine the association between the APOE4 allele and a negative outcome. A secondary objective was to investigate the association between the APOE4 allele and delayed ischemia, a major complication of SAH.
We searched MEDLINE, EMBASE, the Cochrane Library, CINHAL, LILACS, and www.google.it through March 2006. We hand-searched journals, international conference proceedings, and reference lists of retrieved articles. Individual patient data were requested from the corresponding authors of the original articles. Information on study design, participant characteristics, clinical outcome, delayed ischemia, and confounder distribution were independently abstracted by two investigators.
We included eight observational studies (696 patients for the clinical outcome and 600 for the delayed ischemia analyses). The corresponding authors of all the retrieved publications but one gave their original data. Summary odds ratios (ORs) were calculated by means of the random-effect model. The risk of a negative outcome (OR = 2.558; 95% CI 1.610 to 4.065) and delayed ischemia (OR = 2.044; 95% CI 1.269 to 3.291) were increased in the E4 carriers.
In patients with subarachnoid hemorrhage, the expression of the E4 allele is associated with a higher risk of a negative outcome and delayed ischemia.</description><identifier>ISSN: 0028-3878</identifier><identifier>EISSN: 1526-632X</identifier><identifier>DOI: 10.1212/01.wnl.0000267640.03300.6b</identifier><identifier>PMID: 17709709</identifier><identifier>CODEN: NEURAI</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Apolipoprotein E4 - genetics ; Biological and medical sciences ; Brain - blood supply ; Brain - metabolism ; Brain - physiopathology ; Brain Chemistry - genetics ; Brain Ischemia - etiology ; Brain Ischemia - genetics ; Brain Ischemia - physiopathology ; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases ; DNA Mutational Analysis ; Female ; Genetic Markers - genetics ; Genetic Predisposition to Disease - genetics ; Genetic Testing ; Genotype ; Heterozygote ; Humans ; Male ; Medical sciences ; Middle Aged ; Neurology ; Predictive Value of Tests ; Prognosis ; Risk Factors ; Subarachnoid Hemorrhage - complications ; Time Factors ; Vascular diseases and vascular malformations of the nervous system</subject><ispartof>Neurology, 2007-08, Vol.69 (8), p.766-775</ispartof><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c321t-7b9fd077216a7a171c7937fe8f5a7084ecc1ce4bc4ea0eaa2d384a8cb1b8c9a33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19018772$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17709709$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>LANTERNA, L. A</creatorcontrib><creatorcontrib>RUIGROK, Y</creatorcontrib><creatorcontrib>ALEXANDER, S</creatorcontrib><creatorcontrib>TANG, J</creatorcontrib><creatorcontrib>BIROLI, F</creatorcontrib><creatorcontrib>DUNN, L. T</creatorcontrib><creatorcontrib>POON, W. S</creatorcontrib><title>Meta-analysis of APOE genotype and subarachnoid hemorrhage : Clinical outcome and delayed ischemia</title><title>Neurology</title><addtitle>Neurology</addtitle><description>Emerging evidence suggests that the APOE4 allele may increase the risk of a negative outcome in patients with aneurysmal subarachnoid hemorrhage (SAH), but the results are conflicting. A genetic variable predicting the individual clinical course is currently lacking.
To examine the association between the APOE4 allele and a negative outcome. A secondary objective was to investigate the association between the APOE4 allele and delayed ischemia, a major complication of SAH.
We searched MEDLINE, EMBASE, the Cochrane Library, CINHAL, LILACS, and www.google.it through March 2006. We hand-searched journals, international conference proceedings, and reference lists of retrieved articles. Individual patient data were requested from the corresponding authors of the original articles. Information on study design, participant characteristics, clinical outcome, delayed ischemia, and confounder distribution were independently abstracted by two investigators.
We included eight observational studies (696 patients for the clinical outcome and 600 for the delayed ischemia analyses). The corresponding authors of all the retrieved publications but one gave their original data. Summary odds ratios (ORs) were calculated by means of the random-effect model. The risk of a negative outcome (OR = 2.558; 95% CI 1.610 to 4.065) and delayed ischemia (OR = 2.044; 95% CI 1.269 to 3.291) were increased in the E4 carriers.
In patients with subarachnoid hemorrhage, the expression of the E4 allele is associated with a higher risk of a negative outcome and delayed ischemia.</description><subject>Apolipoprotein E4 - genetics</subject><subject>Biological and medical sciences</subject><subject>Brain - blood supply</subject><subject>Brain - metabolism</subject><subject>Brain - physiopathology</subject><subject>Brain Chemistry - genetics</subject><subject>Brain Ischemia - etiology</subject><subject>Brain Ischemia - genetics</subject><subject>Brain Ischemia - physiopathology</subject><subject>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</subject><subject>DNA Mutational Analysis</subject><subject>Female</subject><subject>Genetic Markers - genetics</subject><subject>Genetic Predisposition to Disease - genetics</subject><subject>Genetic Testing</subject><subject>Genotype</subject><subject>Heterozygote</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neurology</subject><subject>Predictive Value of Tests</subject><subject>Prognosis</subject><subject>Risk Factors</subject><subject>Subarachnoid Hemorrhage - complications</subject><subject>Time Factors</subject><subject>Vascular diseases and vascular malformations of the nervous system</subject><issn>0028-3878</issn><issn>1526-632X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU2LFDEQhoMo7rj6FyQIeus2lfR0kr0tw_oBK-tBwVuopKt3Wro7Y9KNzL83OgNztCioQz31wfsy9gZEDRLkewH173msRQnZ6rYRtVBKiLr1T9gGtrKtWiV_PGWb0jeVMtpcsRc5_xSiNLV9zq5Aa2FLbpj_QgtWOON4zEPmsee3Xx_u-CPNcTkeiOPc8bx6TBj2cxw6vqcpprTHR-I3fDcO8xBw5HFdQpxOeEcjHqnjQw4FHvAle9bjmOnVuV6z7x_uvu0-VfcPHz_vbu-roCQslfa274TWElrUCBqCtkr3ZPotamEaCgECNT40hIIQZadMgyZ48CZYVOqavTvtPaT4a6W8uKm8QOOIM8U1u9aAkVps_wuC3ZYvrC3gzQkMKeacqHeHNEyYjg6E-2uFE-CKFe5ihftnhWt9GX59vrL6ibrL6Fn7Arw9A5iLhn3COQz5wlkBpsih_gDy7pPt</recordid><startdate>20070821</startdate><enddate>20070821</enddate><creator>LANTERNA, L. A</creator><creator>RUIGROK, Y</creator><creator>ALEXANDER, S</creator><creator>TANG, J</creator><creator>BIROLI, F</creator><creator>DUNN, L. T</creator><creator>POON, W. S</creator><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>20070821</creationdate><title>Meta-analysis of APOE genotype and subarachnoid hemorrhage : Clinical outcome and delayed ischemia</title><author>LANTERNA, L. A ; RUIGROK, Y ; ALEXANDER, S ; TANG, J ; BIROLI, F ; DUNN, L. T ; POON, W. 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Prion diseases</topic><topic>DNA Mutational Analysis</topic><topic>Female</topic><topic>Genetic Markers - genetics</topic><topic>Genetic Predisposition to Disease - genetics</topic><topic>Genetic Testing</topic><topic>Genotype</topic><topic>Heterozygote</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neurology</topic><topic>Predictive Value of Tests</topic><topic>Prognosis</topic><topic>Risk Factors</topic><topic>Subarachnoid Hemorrhage - complications</topic><topic>Time Factors</topic><topic>Vascular diseases and vascular malformations of the nervous system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>LANTERNA, L. A</creatorcontrib><creatorcontrib>RUIGROK, Y</creatorcontrib><creatorcontrib>ALEXANDER, S</creatorcontrib><creatorcontrib>TANG, J</creatorcontrib><creatorcontrib>BIROLI, F</creatorcontrib><creatorcontrib>DUNN, L. T</creatorcontrib><creatorcontrib>POON, W. S</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Neurology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>LANTERNA, L. A</au><au>RUIGROK, Y</au><au>ALEXANDER, S</au><au>TANG, J</au><au>BIROLI, F</au><au>DUNN, L. T</au><au>POON, W. S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Meta-analysis of APOE genotype and subarachnoid hemorrhage : Clinical outcome and delayed ischemia</atitle><jtitle>Neurology</jtitle><addtitle>Neurology</addtitle><date>2007-08-21</date><risdate>2007</risdate><volume>69</volume><issue>8</issue><spage>766</spage><epage>775</epage><pages>766-775</pages><issn>0028-3878</issn><eissn>1526-632X</eissn><coden>NEURAI</coden><abstract>Emerging evidence suggests that the APOE4 allele may increase the risk of a negative outcome in patients with aneurysmal subarachnoid hemorrhage (SAH), but the results are conflicting. A genetic variable predicting the individual clinical course is currently lacking.
To examine the association between the APOE4 allele and a negative outcome. A secondary objective was to investigate the association between the APOE4 allele and delayed ischemia, a major complication of SAH.
We searched MEDLINE, EMBASE, the Cochrane Library, CINHAL, LILACS, and www.google.it through March 2006. We hand-searched journals, international conference proceedings, and reference lists of retrieved articles. Individual patient data were requested from the corresponding authors of the original articles. Information on study design, participant characteristics, clinical outcome, delayed ischemia, and confounder distribution were independently abstracted by two investigators.
We included eight observational studies (696 patients for the clinical outcome and 600 for the delayed ischemia analyses). The corresponding authors of all the retrieved publications but one gave their original data. Summary odds ratios (ORs) were calculated by means of the random-effect model. The risk of a negative outcome (OR = 2.558; 95% CI 1.610 to 4.065) and delayed ischemia (OR = 2.044; 95% CI 1.269 to 3.291) were increased in the E4 carriers.
In patients with subarachnoid hemorrhage, the expression of the E4 allele is associated with a higher risk of a negative outcome and delayed ischemia.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>17709709</pmid><doi>10.1212/01.wnl.0000267640.03300.6b</doi><tpages>10</tpages></addata></record> |
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| ispartof | Neurology, 2007-08, Vol.69 (8), p.766-775 |
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| subjects | Apolipoprotein E4 - genetics Biological and medical sciences Brain - blood supply Brain - metabolism Brain - physiopathology Brain Chemistry - genetics Brain Ischemia - etiology Brain Ischemia - genetics Brain Ischemia - physiopathology Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases DNA Mutational Analysis Female Genetic Markers - genetics Genetic Predisposition to Disease - genetics Genetic Testing Genotype Heterozygote Humans Male Medical sciences Middle Aged Neurology Predictive Value of Tests Prognosis Risk Factors Subarachnoid Hemorrhage - complications Time Factors Vascular diseases and vascular malformations of the nervous system |
| title | Meta-analysis of APOE genotype and subarachnoid hemorrhage : Clinical outcome and delayed ischemia |
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