PET imaging of infection with a HYNIC-conjugated LTB4 antagonist labeled with F-18 via hydrazone formation

Abstract It was previously shown that the99m Tc-labeled hydrazinonicotinamide (HYNIC)-conjugated LTB4 antagonist MB81 visualized infectious foci in rabbits adequately and within a few hours after injection. Here, the bivalent HYNIC-conjugated LTB4 antagonist MB67 (analog of MB81) was fluorinated wit...

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Veröffentlicht in:	Nuclear medicine and biology 2007-08, Vol.34 (6), p.691-695
Hauptverfasser:	Rennen, Huub J.J.M, Laverman, Peter, van Eerd, Julliëtte E.M, Oyen, Wim J.G, Corstens, Frans H.M, Boerman, Otto C
Format:	Artikel
Sprache:	eng
Schlagworte:	Abscess - diagnostic imaging Animals Escherichia coli Infections - diagnostic imaging Fluorine Radioisotopes - chemistry Hydrazines Hydrazone formation Hydrazones - chemical synthesis HYNIC-conjugated LTB4 antagonist Indicators and Reagents Infection - diagnostic imaging Isotope Labeling Leukotriene B4 - antagonists & inhibitors Muscular Diseases - diagnostic imaging Niacinamide - analogs & derivatives PET imaging Positron-Emission Tomography Rabbits Radiology Radiopharmaceuticals - chemical synthesis Radiopharmaceuticals - pharmacokinetics Technetium - chemistry Tissue Distribution
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