Overexpression of cyclin D1 and cortactin is primarily independent of gene amplification in salivary gland adenoid cystic carcinoma

Summary Adenoid cystic carcinoma (ACC) of the salivary glands exhibits persistent growth, invasion and metastasis. Chromosome 11q13 amplification is a frequent event associated with tumor progression in a number of carcinomas and is associated with poor prognosis. Two genes within the 11q13 amplicon...

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Veröffentlicht in:	Oral oncology 2007-09, Vol.43 (8), p.735-741
Hauptverfasser:	Greer, Robert O, Said, Sherif, Shroyer, Kenneth R, Marileila, Varella-Garcia, Weed, Scott A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoid cystic carcinoma Adult Aged Aged, 80 and over Biological and medical sciences Carcinoma, Adenoid Cystic - genetics Carcinoma, Adenoid Cystic - metabolism Chromosome 11q13 Chromosomes, Human, Pair 11 - genetics Cortactin Cortactin - genetics Cortactin - metabolism Cyclin D1 Cyclin D1 - genetics Cyclin D1 - metabolism Female Gene Amplification Gene Expression Regulation, Neoplastic Hematology, Oncology and Palliative Medicine Humans In Situ Hybridization, Fluorescence Invasion Male Medical sciences Metastasis Middle Aged Neoplasm Proteins - genetics Neoplasm Proteins - metabolism Otolaryngology Otorhinolaryngology. Stomatology Retrospective Studies Salivary Gland Neoplasms - genetics Salivary Gland Neoplasms - metabolism Tumors Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology
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