The Paneth cell alpha-defensin deficiency of ileal Crohn's disease is linked to Wnt/Tcf-4

Ileal Crohn's disease (CD), a chronic mucosal inflammation, is characterized by two pertinent features: a specific decrease of Paneth cell-produced antimicrobial alpha-defensins and the presence of mucosal-adherent bacteria. A mutation in NOD2, the muramyl dipeptide recognition receptor, is fou...

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Veröffentlicht in:	Journal of Immunology 2007-09, Vol.179 (5), p.3109-3118
Hauptverfasser:	Wehkamp, Jan, Wang, Guoxing, Kübler, Irmgard, Nuding, Sabine, Gregorieff, Alex, Schnabel, Anke, Kays, Robert J, Fellermann, Klaus, Burk, Oliver, Schwab, Matthias, Clevers, Hans, Bevins, Charles L, Stange, Eduard F
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha-Defensins - deficiency alpha-Defensins - genetics Animals Crohn Disease - etiology Crohn Disease - genetics Crohn Disease - metabolism Humans Ileitis - etiology Ileitis - genetics Ileitis - metabolism Mice Mice, Knockout Nod2 Signaling Adaptor Protein - genetics Paneth Cells - metabolism Promoter Regions, Genetic TCF Transcription Factors - genetics TCF Transcription Factors - metabolism Transcription Factor 7-Like 2 Protein Wnt Proteins - genetics Wnt Proteins - metabolism
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