Improved postoperative outcomes associated with preoperative statin therapy
Statin therapy is well established for prevention of cardiovascular disease. Statins may also reduce postoperative mortality and morbidity via a pleiotropic (non-lipid-lowering) effect. The authors conducted a meta-analysis to determine the influence of statin treatment on adverse postoperative outc...
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| Veröffentlicht in: | Anesthesiology (Philadelphia) 2006-12, Vol.105 (6), p.1260-1272 |
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| container_title | Anesthesiology (Philadelphia) |
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| creator | HINDLER, Katja SHAW, Andrew D SAMUELS, Joshua FULTON, Stephanie COLLARD, Charles D RIEDEL, Bernhard |
| description | Statin therapy is well established for prevention of cardiovascular disease. Statins may also reduce postoperative mortality and morbidity via a pleiotropic (non-lipid-lowering) effect. The authors conducted a meta-analysis to determine the influence of statin treatment on adverse postoperative outcomes in patients undergoing cardiac, vascular, or noncardiovascular surgery. Two independent authors abstracted data from 12 retrospective and 3 prospective trials (n = 223,010 patients). A meta-analysis was performed to evaluate the overall effect of preoperative statin therapy on postoperative outcomes. Preoperative statin therapy was associated with 38% and 59% reduction in the risk of mortality after cardiac (1.9% vs. 3.1%; P = 0.0001) and vascular (1.7% vs. 6.1%; P = 0.0001) surgery, respectively. When including noncardiac surgery, a 44% reduction in mortality (2.2% vs. 3.2%; P = 0.0001) was observed. Preoperative statin therapy may reduce postoperative mortality in patients undergoing surgical procedures. However, the statin associated effects on postoperative cardiovascular morbidity are too variable to draw any conclusion. |
| doi_str_mv | 10.1097/00000542-200612000-00027 |
| format | Article |
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However, the statin associated effects on postoperative cardiovascular morbidity are too variable to draw any conclusion.</description><identifier>ISSN: 0003-3022</identifier><identifier>EISSN: 1528-1175</identifier><identifier>DOI: 10.1097/00000542-200612000-00027</identifier><identifier>PMID: 17122590</identifier><identifier>CODEN: ANESAV</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott</publisher><subject>Anesthesia ; Anesthesia. Intensive care medicine. Transfusions. 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Statins may also reduce postoperative mortality and morbidity via a pleiotropic (non-lipid-lowering) effect. The authors conducted a meta-analysis to determine the influence of statin treatment on adverse postoperative outcomes in patients undergoing cardiac, vascular, or noncardiovascular surgery. Two independent authors abstracted data from 12 retrospective and 3 prospective trials (n = 223,010 patients). A meta-analysis was performed to evaluate the overall effect of preoperative statin therapy on postoperative outcomes. Preoperative statin therapy was associated with 38% and 59% reduction in the risk of mortality after cardiac (1.9% vs. 3.1%; P = 0.0001) and vascular (1.7% vs. 6.1%; P = 0.0001) surgery, respectively. When including noncardiac surgery, a 44% reduction in mortality (2.2% vs. 3.2%; P = 0.0001) was observed. Preoperative statin therapy may reduce postoperative mortality in patients undergoing surgical procedures. However, the statin associated effects on postoperative cardiovascular morbidity are too variable to draw any conclusion.</description><subject>Anesthesia</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cardiac Surgical Procedures - adverse effects</subject><subject>Cardiotonic Agents</subject><subject>Data Interpretation, Statistical</subject><subject>Humans</subject><subject>Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use</subject><subject>Medical sciences</subject><subject>Prospective Studies</subject><subject>Randomized Controlled Trials as Topic</subject><subject>Retrospective Studies</subject><subject>Surgical Procedures, Operative</subject><subject>Treatment Outcome</subject><subject>Vascular Surgical Procedures - adverse effects</subject><issn>0003-3022</issn><issn>1528-1175</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkN9PwyAQgInRuDn9F0xf9K3KQSnwaBZ_LC7xRZ8JozSraUcFOrP_XuaqI4ELl--O40MoA3wHWPJ7vF-sIDnBuIR04Dxtwk_QFBgROQBnp2iacjSnmJAJugjhM105o-IcTYADIUziKXpddL13W1tlvQvR9dbr2Gxt5oZoXGdDpkNwptExEd9NXGe9t0cqxBQ3WVynRL-7RGe1boO9GuMMfTw9vs9f8uXb82L-sMwNlTTmwIkUQpKaVowzMEZKBhKnj0lbghFsZUVhdZqwpmUJgImtKswLUVNWFDWhM3R76Jsm_xpsiKprgrFtqzfWDUGVArgUpUigOIDGuxC8rVXvm077nQKs9iLVn0j1L1L9ikyl1-Mbw6qz1bFwNJeAmxHQwei29npjmnDkBCUlSEF_AB-Leq0</recordid><startdate>20061201</startdate><enddate>20061201</enddate><creator>HINDLER, Katja</creator><creator>SHAW, Andrew D</creator><creator>SAMUELS, Joshua</creator><creator>FULTON, Stephanie</creator><creator>COLLARD, Charles D</creator><creator>RIEDEL, Bernhard</creator><general>Lippincott</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20061201</creationdate><title>Improved postoperative outcomes associated with preoperative statin therapy</title><author>HINDLER, Katja ; SHAW, Andrew D ; SAMUELS, Joshua ; FULTON, Stephanie ; COLLARD, Charles D ; RIEDEL, Bernhard</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c393t-17298892f3d5751cc9951901099e61c85be84ea122f3661102edd0748f3544f23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Anesthesia</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cardiac Surgical Procedures - adverse effects</topic><topic>Cardiotonic Agents</topic><topic>Data Interpretation, Statistical</topic><topic>Humans</topic><topic>Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use</topic><topic>Medical sciences</topic><topic>Prospective Studies</topic><topic>Randomized Controlled Trials as Topic</topic><topic>Retrospective Studies</topic><topic>Surgical Procedures, Operative</topic><topic>Treatment Outcome</topic><topic>Vascular Surgical Procedures - adverse effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>HINDLER, Katja</creatorcontrib><creatorcontrib>SHAW, Andrew D</creatorcontrib><creatorcontrib>SAMUELS, Joshua</creatorcontrib><creatorcontrib>FULTON, Stephanie</creatorcontrib><creatorcontrib>COLLARD, Charles D</creatorcontrib><creatorcontrib>RIEDEL, Bernhard</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Anesthesiology (Philadelphia)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>HINDLER, Katja</au><au>SHAW, Andrew D</au><au>SAMUELS, Joshua</au><au>FULTON, Stephanie</au><au>COLLARD, Charles D</au><au>RIEDEL, Bernhard</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Improved postoperative outcomes associated with preoperative statin therapy</atitle><jtitle>Anesthesiology (Philadelphia)</jtitle><addtitle>Anesthesiology</addtitle><date>2006-12-01</date><risdate>2006</risdate><volume>105</volume><issue>6</issue><spage>1260</spage><epage>1272</epage><pages>1260-1272</pages><issn>0003-3022</issn><eissn>1528-1175</eissn><coden>ANESAV</coden><abstract>Statin therapy is well established for prevention of cardiovascular disease. Statins may also reduce postoperative mortality and morbidity via a pleiotropic (non-lipid-lowering) effect. The authors conducted a meta-analysis to determine the influence of statin treatment on adverse postoperative outcomes in patients undergoing cardiac, vascular, or noncardiovascular surgery. Two independent authors abstracted data from 12 retrospective and 3 prospective trials (n = 223,010 patients). A meta-analysis was performed to evaluate the overall effect of preoperative statin therapy on postoperative outcomes. Preoperative statin therapy was associated with 38% and 59% reduction in the risk of mortality after cardiac (1.9% vs. 3.1%; P = 0.0001) and vascular (1.7% vs. 6.1%; P = 0.0001) surgery, respectively. When including noncardiac surgery, a 44% reduction in mortality (2.2% vs. 3.2%; P = 0.0001) was observed. Preoperative statin therapy may reduce postoperative mortality in patients undergoing surgical procedures. 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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Journals@Ovid Complete |
| subjects | Anesthesia Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Animals Biological and medical sciences Cardiac Surgical Procedures - adverse effects Cardiotonic Agents Data Interpretation, Statistical Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use Medical sciences Prospective Studies Randomized Controlled Trials as Topic Retrospective Studies Surgical Procedures, Operative Treatment Outcome Vascular Surgical Procedures - adverse effects |
| title | Improved postoperative outcomes associated with preoperative statin therapy |
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