Orthogonal array design for optimizing extraction efficiency of active constituents from Jakyak-Gamcho Decoction, the complex formula of herbal medicines, Paeoniae Radix and Glycyrrhizae Radix
A complex formula composed of Paeonia lactiflora PALL. and Glycyrrhiza uralensis Fisch., which is called as Jakyak-Gamcho Decoction (JGD), has been used for a pain-relieving function and muscle spasms due to blood deficiency in the traditional medicine. In this study, the anti-inflammatory activity...
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| Veröffentlicht in: | Journal of ethnopharmacology 2007-09, Vol.113 (2), p.306-311 |
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| creator | Guo, Lianyu Cho, So Yean Kang, Sam Sik Lee, Seung-Ho Baek, Hum-Young Kim, Yeong Shik |
| description | A complex formula composed of
Paeonia lactiflora PALL. and
Glycyrrhiza uralensis Fisch., which is called as Jakyak-Gamcho Decoction (JGD), has been used for a pain-relieving function and muscle spasms due to blood deficiency in the traditional medicine. In this study, the anti-inflammatory activity of JGD was evaluated based on the quantitative determinations and the relative proportions of six major constituents in the decoction mixture extracted by orthogonal array methods. Our results suggest that the three parameters are all crucial factors. The optimized conditions for extraction were therefore established [solvent (water); pH value (4); extraction number (4)]. We also optimized the extraction conditions related to anti-inflammatory activity [solvent (70% EtOH); pH value (6); extraction number (4)]. So, we found that the bioactivity was responsible for mixed components but not individual one. It was proportionally associated with the amounts of some components in the extracts of herbal medicines. When the proportion of the active components was similar to each other, they had the similar functions. Furthermore, the results could establish a model system for the quality assurance of herbal preparations, and provided a new paradigm of active components-pharmacodynamics, which is used for illustrating the connections between the bioactivities and the proportion of active constituents in the extracts of herbal medicines. |
| doi_str_mv | 10.1016/j.jep.2007.06.013 |
| format | Article |
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Paeonia lactiflora PALL. and
Glycyrrhiza uralensis Fisch., which is called as Jakyak-Gamcho Decoction (JGD), has been used for a pain-relieving function and muscle spasms due to blood deficiency in the traditional medicine. In this study, the anti-inflammatory activity of JGD was evaluated based on the quantitative determinations and the relative proportions of six major constituents in the decoction mixture extracted by orthogonal array methods. Our results suggest that the three parameters are all crucial factors. The optimized conditions for extraction were therefore established [solvent (water); pH value (4); extraction number (4)]. We also optimized the extraction conditions related to anti-inflammatory activity [solvent (70% EtOH); pH value (6); extraction number (4)]. So, we found that the bioactivity was responsible for mixed components but not individual one. It was proportionally associated with the amounts of some components in the extracts of herbal medicines. When the proportion of the active components was similar to each other, they had the similar functions. Furthermore, the results could establish a model system for the quality assurance of herbal preparations, and provided a new paradigm of active components-pharmacodynamics, which is used for illustrating the connections between the bioactivities and the proportion of active constituents in the extracts of herbal medicines.</description><identifier>ISSN: 0378-8741</identifier><identifier>EISSN: 1872-7573</identifier><identifier>DOI: 10.1016/j.jep.2007.06.013</identifier><identifier>PMID: 17681441</identifier><identifier>CODEN: JOETD7</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject><![CDATA[Alkaline Phosphatase - genetics ; Alkaline Phosphatase - metabolism ; Animals ; anti-inflammatory activity ; Benzoates - chemistry ; Benzoates - isolation & purification ; bioassays ; Biological and medical sciences ; Bridged-Ring Compounds - chemistry ; Bridged-Ring Compounds - isolation & purification ; Cell Line ; Cell Survival - drug effects ; Chalcone - analogs & derivatives ; Chalcone - chemistry ; Chalcone - isolation & purification ; chemical constituents of plants ; Chemical Fractionation - methods ; Chromatography, High Pressure Liquid ; Ethanol - chemistry ; ethnobotany ; extraction ; Flavanones - chemistry ; Flavanones - isolation & purification ; General pharmacology ; Glucosides - chemistry ; Glucosides - isolation & purification ; Glycyrrhiza - chemistry ; Glycyrrhiza uralensis ; Glycyrrhiza uralensis Fisch ; Glycyrrhizic Acid - chemistry ; Glycyrrhizic Acid - isolation & purification ; Herbal Medicine ; herbal medicines ; inflammation ; Jakyak-Gamcho Decoction ; Lipopolysaccharides - pharmacology ; Macrophages - cytology ; Macrophages - drug effects ; Macrophages - metabolism ; Medical sciences ; medicinal plants ; medicinal properties ; mice ; Monoterpenes ; NF-kappa B - genetics ; NF-kappa B - metabolism ; Nitric Oxide - metabolism ; optimization ; Optimization of extraction ; Oriental traditional medicine ; Orthogonal array design ; Paeonia - chemistry ; Paeonia lactiflora ; Paeonia lactiflora PALL ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; plant extracts ; Plant Extracts - chemistry ; Plant Extracts - isolation & purification ; Research Design ; roots ; Solubility ; Technology, Pharmaceutical - methods ; Water - chemistry]]></subject><ispartof>Journal of ethnopharmacology, 2007-09, Vol.113 (2), p.306-311</ispartof><rights>2007</rights><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c405t-64170447c2a3db729087ae1c96c376c58d3f4e135587ac35d7b97e1cb1c7341a3</citedby><cites>FETCH-LOGICAL-c405t-64170447c2a3db729087ae1c96c376c58d3f4e135587ac35d7b97e1cb1c7341a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jep.2007.06.013$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27928,27929,45999</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19006040$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17681441$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Guo, Lianyu</creatorcontrib><creatorcontrib>Cho, So Yean</creatorcontrib><creatorcontrib>Kang, Sam Sik</creatorcontrib><creatorcontrib>Lee, Seung-Ho</creatorcontrib><creatorcontrib>Baek, Hum-Young</creatorcontrib><creatorcontrib>Kim, Yeong Shik</creatorcontrib><title>Orthogonal array design for optimizing extraction efficiency of active constituents from Jakyak-Gamcho Decoction, the complex formula of herbal medicines, Paeoniae Radix and Glycyrrhizae Radix</title><title>Journal of ethnopharmacology</title><addtitle>J Ethnopharmacol</addtitle><description>A complex formula composed of
Paeonia lactiflora PALL. and
Glycyrrhiza uralensis Fisch., which is called as Jakyak-Gamcho Decoction (JGD), has been used for a pain-relieving function and muscle spasms due to blood deficiency in the traditional medicine. In this study, the anti-inflammatory activity of JGD was evaluated based on the quantitative determinations and the relative proportions of six major constituents in the decoction mixture extracted by orthogonal array methods. Our results suggest that the three parameters are all crucial factors. The optimized conditions for extraction were therefore established [solvent (water); pH value (4); extraction number (4)]. We also optimized the extraction conditions related to anti-inflammatory activity [solvent (70% EtOH); pH value (6); extraction number (4)]. So, we found that the bioactivity was responsible for mixed components but not individual one. It was proportionally associated with the amounts of some components in the extracts of herbal medicines. When the proportion of the active components was similar to each other, they had the similar functions. Furthermore, the results could establish a model system for the quality assurance of herbal preparations, and provided a new paradigm of active components-pharmacodynamics, which is used for illustrating the connections between the bioactivities and the proportion of active constituents in the extracts of herbal medicines.</description><subject>Alkaline Phosphatase - genetics</subject><subject>Alkaline Phosphatase - metabolism</subject><subject>Animals</subject><subject>anti-inflammatory activity</subject><subject>Benzoates - chemistry</subject><subject>Benzoates - isolation & purification</subject><subject>bioassays</subject><subject>Biological and medical sciences</subject><subject>Bridged-Ring Compounds - chemistry</subject><subject>Bridged-Ring Compounds - isolation & purification</subject><subject>Cell Line</subject><subject>Cell Survival - drug effects</subject><subject>Chalcone - analogs & derivatives</subject><subject>Chalcone - chemistry</subject><subject>Chalcone - isolation & purification</subject><subject>chemical constituents of plants</subject><subject>Chemical Fractionation - methods</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Ethanol - chemistry</subject><subject>ethnobotany</subject><subject>extraction</subject><subject>Flavanones - chemistry</subject><subject>Flavanones - isolation & purification</subject><subject>General pharmacology</subject><subject>Glucosides - chemistry</subject><subject>Glucosides - isolation & purification</subject><subject>Glycyrrhiza - chemistry</subject><subject>Glycyrrhiza uralensis</subject><subject>Glycyrrhiza uralensis Fisch</subject><subject>Glycyrrhizic Acid - chemistry</subject><subject>Glycyrrhizic Acid - isolation & purification</subject><subject>Herbal Medicine</subject><subject>herbal medicines</subject><subject>inflammation</subject><subject>Jakyak-Gamcho Decoction</subject><subject>Lipopolysaccharides - pharmacology</subject><subject>Macrophages - cytology</subject><subject>Macrophages - drug effects</subject><subject>Macrophages - metabolism</subject><subject>Medical sciences</subject><subject>medicinal plants</subject><subject>medicinal properties</subject><subject>mice</subject><subject>Monoterpenes</subject><subject>NF-kappa B - genetics</subject><subject>NF-kappa B - metabolism</subject><subject>Nitric Oxide - metabolism</subject><subject>optimization</subject><subject>Optimization of extraction</subject><subject>Oriental traditional medicine</subject><subject>Orthogonal array design</subject><subject>Paeonia - chemistry</subject><subject>Paeonia lactiflora</subject><subject>Paeonia lactiflora PALL</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>plant extracts</subject><subject>Plant Extracts - chemistry</subject><subject>Plant Extracts - isolation & purification</subject><subject>Research Design</subject><subject>roots</subject><subject>Solubility</subject><subject>Technology, Pharmaceutical - methods</subject><subject>Water - chemistry</subject><issn>0378-8741</issn><issn>1872-7573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kUFv1DAQhSMEoqXwA7iAL3BqlnHixFlxQgUWUKUioGdr1pnsepvYi-2tNv11_DSc7qLeOFl6_ubN6L0se8lhxoHX7zazDW1nBYCcQT0DXj7KTnkji1xWsnycnUIpm7yRgp9kz0LYQAK5gKfZCZd1w4Xgp9mfKx_XbuUs9gy9x5G1FMzKss555rbRDObO2BWjffSoo3GWUdcZbcjqkbmOTeItMe1siCbuyMbAOu8G9g1vRrzJFzjotWMfSbv78XMW1xM-bHvaT1uGXY-T0Zr8Mh0xUJvcLYVz9h3JWYPEfmBr9gxtyxb9qEfv1-bun_w8e9JhH-jF8T3Lrj9_-nXxJb-8Wny9-HCZawFVzGvBJQghdYFlu5TFHBqJxPW81qWsddW0ZSeIl1WVdF1WrVzOZfpfci1LwbE8y94efLfe_d5RiGowQVPfoyW3CyoFKhs5hwTyA6i9C8FTp7beDOhHxUFNtamNSrWpqTYFtUq1pZlXR_PdMgXwMHHsKQFvjgAGjX3n0WoTHrg5QA1iWv76wHXoFK58Yq5_FmkFQAN1A0Ui3h8ISmHdGvIq3JeZYveko2qd-c-hfwGlZcKD</recordid><startdate>20070905</startdate><enddate>20070905</enddate><creator>Guo, Lianyu</creator><creator>Cho, So Yean</creator><creator>Kang, Sam Sik</creator><creator>Lee, Seung-Ho</creator><creator>Baek, Hum-Young</creator><creator>Kim, Yeong Shik</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20070905</creationdate><title>Orthogonal array design for optimizing extraction efficiency of active constituents from Jakyak-Gamcho Decoction, the complex formula of herbal medicines, Paeoniae Radix and Glycyrrhizae Radix</title><author>Guo, Lianyu ; Cho, So Yean ; Kang, Sam Sik ; Lee, Seung-Ho ; Baek, Hum-Young ; Kim, Yeong Shik</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c405t-64170447c2a3db729087ae1c96c376c58d3f4e135587ac35d7b97e1cb1c7341a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Alkaline Phosphatase - genetics</topic><topic>Alkaline Phosphatase - metabolism</topic><topic>Animals</topic><topic>anti-inflammatory activity</topic><topic>Benzoates - chemistry</topic><topic>Benzoates - isolation & purification</topic><topic>bioassays</topic><topic>Biological and medical sciences</topic><topic>Bridged-Ring Compounds - chemistry</topic><topic>Bridged-Ring Compounds - isolation & purification</topic><topic>Cell Line</topic><topic>Cell Survival - drug effects</topic><topic>Chalcone - analogs & derivatives</topic><topic>Chalcone - chemistry</topic><topic>Chalcone - isolation & purification</topic><topic>chemical constituents of plants</topic><topic>Chemical Fractionation - methods</topic><topic>Chromatography, High Pressure Liquid</topic><topic>Ethanol - chemistry</topic><topic>ethnobotany</topic><topic>extraction</topic><topic>Flavanones - chemistry</topic><topic>Flavanones - isolation & purification</topic><topic>General pharmacology</topic><topic>Glucosides - chemistry</topic><topic>Glucosides - isolation & purification</topic><topic>Glycyrrhiza - chemistry</topic><topic>Glycyrrhiza uralensis</topic><topic>Glycyrrhiza uralensis Fisch</topic><topic>Glycyrrhizic Acid - chemistry</topic><topic>Glycyrrhizic Acid - isolation & purification</topic><topic>Herbal Medicine</topic><topic>herbal medicines</topic><topic>inflammation</topic><topic>Jakyak-Gamcho Decoction</topic><topic>Lipopolysaccharides - pharmacology</topic><topic>Macrophages - cytology</topic><topic>Macrophages - drug effects</topic><topic>Macrophages - metabolism</topic><topic>Medical sciences</topic><topic>medicinal plants</topic><topic>medicinal properties</topic><topic>mice</topic><topic>Monoterpenes</topic><topic>NF-kappa B - genetics</topic><topic>NF-kappa B - metabolism</topic><topic>Nitric Oxide - metabolism</topic><topic>optimization</topic><topic>Optimization of extraction</topic><topic>Oriental traditional medicine</topic><topic>Orthogonal array design</topic><topic>Paeonia - chemistry</topic><topic>Paeonia lactiflora</topic><topic>Paeonia lactiflora PALL</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>plant extracts</topic><topic>Plant Extracts - chemistry</topic><topic>Plant Extracts - isolation & purification</topic><topic>Research Design</topic><topic>roots</topic><topic>Solubility</topic><topic>Technology, Pharmaceutical - methods</topic><topic>Water - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Guo, Lianyu</creatorcontrib><creatorcontrib>Cho, So Yean</creatorcontrib><creatorcontrib>Kang, Sam Sik</creatorcontrib><creatorcontrib>Lee, Seung-Ho</creatorcontrib><creatorcontrib>Baek, Hum-Young</creatorcontrib><creatorcontrib>Kim, Yeong Shik</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of ethnopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Guo, Lianyu</au><au>Cho, So Yean</au><au>Kang, Sam Sik</au><au>Lee, Seung-Ho</au><au>Baek, Hum-Young</au><au>Kim, Yeong Shik</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Orthogonal array design for optimizing extraction efficiency of active constituents from Jakyak-Gamcho Decoction, the complex formula of herbal medicines, Paeoniae Radix and Glycyrrhizae Radix</atitle><jtitle>Journal of ethnopharmacology</jtitle><addtitle>J Ethnopharmacol</addtitle><date>2007-09-05</date><risdate>2007</risdate><volume>113</volume><issue>2</issue><spage>306</spage><epage>311</epage><pages>306-311</pages><issn>0378-8741</issn><eissn>1872-7573</eissn><coden>JOETD7</coden><abstract>A complex formula composed of
Paeonia lactiflora PALL. and
Glycyrrhiza uralensis Fisch., which is called as Jakyak-Gamcho Decoction (JGD), has been used for a pain-relieving function and muscle spasms due to blood deficiency in the traditional medicine. In this study, the anti-inflammatory activity of JGD was evaluated based on the quantitative determinations and the relative proportions of six major constituents in the decoction mixture extracted by orthogonal array methods. Our results suggest that the three parameters are all crucial factors. The optimized conditions for extraction were therefore established [solvent (water); pH value (4); extraction number (4)]. We also optimized the extraction conditions related to anti-inflammatory activity [solvent (70% EtOH); pH value (6); extraction number (4)]. So, we found that the bioactivity was responsible for mixed components but not individual one. It was proportionally associated with the amounts of some components in the extracts of herbal medicines. When the proportion of the active components was similar to each other, they had the similar functions. Furthermore, the results could establish a model system for the quality assurance of herbal preparations, and provided a new paradigm of active components-pharmacodynamics, which is used for illustrating the connections between the bioactivities and the proportion of active constituents in the extracts of herbal medicines.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>17681441</pmid><doi>10.1016/j.jep.2007.06.013</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0378-8741 |
| ispartof | Journal of ethnopharmacology, 2007-09, Vol.113 (2), p.306-311 |
| issn | 0378-8741 1872-7573 |
| language | eng |
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| subjects | Alkaline Phosphatase - genetics Alkaline Phosphatase - metabolism Animals anti-inflammatory activity Benzoates - chemistry Benzoates - isolation & purification bioassays Biological and medical sciences Bridged-Ring Compounds - chemistry Bridged-Ring Compounds - isolation & purification Cell Line Cell Survival - drug effects Chalcone - analogs & derivatives Chalcone - chemistry Chalcone - isolation & purification chemical constituents of plants Chemical Fractionation - methods Chromatography, High Pressure Liquid Ethanol - chemistry ethnobotany extraction Flavanones - chemistry Flavanones - isolation & purification General pharmacology Glucosides - chemistry Glucosides - isolation & purification Glycyrrhiza - chemistry Glycyrrhiza uralensis Glycyrrhiza uralensis Fisch Glycyrrhizic Acid - chemistry Glycyrrhizic Acid - isolation & purification Herbal Medicine herbal medicines inflammation Jakyak-Gamcho Decoction Lipopolysaccharides - pharmacology Macrophages - cytology Macrophages - drug effects Macrophages - metabolism Medical sciences medicinal plants medicinal properties mice Monoterpenes NF-kappa B - genetics NF-kappa B - metabolism Nitric Oxide - metabolism optimization Optimization of extraction Oriental traditional medicine Orthogonal array design Paeonia - chemistry Paeonia lactiflora Paeonia lactiflora PALL Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments plant extracts Plant Extracts - chemistry Plant Extracts - isolation & purification Research Design roots Solubility Technology, Pharmaceutical - methods Water - chemistry |
| title | Orthogonal array design for optimizing extraction efficiency of active constituents from Jakyak-Gamcho Decoction, the complex formula of herbal medicines, Paeoniae Radix and Glycyrrhizae Radix |
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