Simple and sensitive determination of menatetrenone and its epoxide metabolite in human plasma
A simple and rapid quantification method was developed for determining menatetrenone and its epoxide metabolite in human plasma. After a simple protein precipitation with methanol, the analytes were chromatographed on a reversed-phase C 18 column and detected by LC/MS/MS with atmospheric pressure ch...
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| Veröffentlicht in: | Journal of pharmaceutical and biomedical analysis 2007-09, Vol.44 (5), p.1178-1182 |
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| container_title | Journal of pharmaceutical and biomedical analysis |
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| creator | Kang, Wonku Jeong, Ji-Hoon Ma, Eunsook Kwon, Kwang-il |
| description | A simple and rapid quantification method was developed for determining menatetrenone and its epoxide metabolite in human plasma. After a simple protein precipitation with methanol, the analytes were chromatographed on a reversed-phase C
18 column and detected by LC/MS/MS with atmospheric pressure chemical ionization. The coefficient of variation of the assay precision was less than 10.1%, and the accuracy ranged from 98.0 to 106.5%. The limit of detection of menatetrenone and its epoxide was 0.5 and 0.2
ng/ml, respectively. This method was used to simultaneously measure the plasma concentration of menatetrenone and its epoxide metabolite from healthy subjects after a single 30
mg oral dose of menatetrenone. |
| doi_str_mv | 10.1016/j.jpba.2007.04.028 |
| format | Article |
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18 column and detected by LC/MS/MS with atmospheric pressure chemical ionization. The coefficient of variation of the assay precision was less than 10.1%, and the accuracy ranged from 98.0 to 106.5%. The limit of detection of menatetrenone and its epoxide was 0.5 and 0.2
ng/ml, respectively. This method was used to simultaneously measure the plasma concentration of menatetrenone and its epoxide metabolite from healthy subjects after a single 30
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18 column and detected by LC/MS/MS with atmospheric pressure chemical ionization. The coefficient of variation of the assay precision was less than 10.1%, and the accuracy ranged from 98.0 to 106.5%. The limit of detection of menatetrenone and its epoxide was 0.5 and 0.2
ng/ml, respectively. This method was used to simultaneously measure the plasma concentration of menatetrenone and its epoxide metabolite from healthy subjects after a single 30
mg oral dose of menatetrenone.</description><subject>Analysis</subject><subject>Analytical, structural and metabolic biochemistry</subject><subject>Biological and medical sciences</subject><subject>Chromatography, Liquid - methods</subject><subject>Epoxide metabolite</subject><subject>Epoxy Compounds - blood</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>General pharmacology</subject><subject>Hemostatics - blood</subject><subject>Hemostatics - metabolism</subject><subject>Humans</subject><subject>LC/MS/MS</subject><subject>Medical sciences</subject><subject>Menatetrenone</subject><subject>Methanol - chemistry</subject><subject>Pharmacology. Drug treatments</subject><subject>Reference Standards</subject><subject>Reproducibility of Results</subject><subject>Sensitivity and Specificity</subject><subject>Solvents - chemistry</subject><subject>Tandem Mass Spectrometry - methods</subject><subject>Time Factors</subject><subject>Vitamin K 2 - analogs & derivatives</subject><subject>Vitamin K 2 - blood</subject><subject>Vitamin K 2 - metabolism</subject><issn>0731-7085</issn><issn>1873-264X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM1q3DAYRUVpaKZpXyCLoE2zs6MfW7IhmxCSthDoog10VaGfz0SDLTmSJqRvXw0zkF1X-kDnXi4HoXNKWkqouNq229XolhEiW9K1hA3v0IYOkjdMdL_fow2RnDaSDP0p-pjzlhDS07H7gE6p7AXlgm3Qn59-WWfAOjicIWRf_AtgBwXS4oMuPgYcJ7xAvaEkCDEcYF8yhjW-egf1t2gTZ18A-4CfdosOeJ11XvQndDLpOcPn43uGHu_vft1-ax5-fP1-e_PQWD50pRFMWE1tXTVqJ-3YmTpUMmunQfajBWPYQAwB17OJCMIpN1aMzmgAXkMdP0OXh941xecd5KIWny3Msw4Qd1mJgcpaxSvIDqBNMecEk1qTX3T6qyhRe6tqq_ZW1d6qIp2qVmvo4ti-Mwu4t8hRYwW-HAGdrZ6npIP1-Y0bq_mO72deHzioLl48JJWth2DB-QS2KBf9_3b8A_FYlwc</recordid><startdate>20070903</startdate><enddate>20070903</enddate><creator>Kang, Wonku</creator><creator>Jeong, Ji-Hoon</creator><creator>Ma, Eunsook</creator><creator>Kwon, Kwang-il</creator><general>Elsevier B.V</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20070903</creationdate><title>Simple and sensitive determination of menatetrenone and its epoxide metabolite in human plasma</title><author>Kang, Wonku ; Jeong, Ji-Hoon ; Ma, Eunsook ; Kwon, Kwang-il</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c384t-626ca1c7569ad7c94b51972ccf8759cebb280b0ed52f060313bc69dbaee375643</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Analysis</topic><topic>Analytical, structural and metabolic biochemistry</topic><topic>Biological and medical sciences</topic><topic>Chromatography, Liquid - methods</topic><topic>Epoxide metabolite</topic><topic>Epoxy Compounds - blood</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>General pharmacology</topic><topic>Hemostatics - blood</topic><topic>Hemostatics - metabolism</topic><topic>Humans</topic><topic>LC/MS/MS</topic><topic>Medical sciences</topic><topic>Menatetrenone</topic><topic>Methanol - chemistry</topic><topic>Pharmacology. Drug treatments</topic><topic>Reference Standards</topic><topic>Reproducibility of Results</topic><topic>Sensitivity and Specificity</topic><topic>Solvents - chemistry</topic><topic>Tandem Mass Spectrometry - methods</topic><topic>Time Factors</topic><topic>Vitamin K 2 - analogs & derivatives</topic><topic>Vitamin K 2 - blood</topic><topic>Vitamin K 2 - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kang, Wonku</creatorcontrib><creatorcontrib>Jeong, Ji-Hoon</creatorcontrib><creatorcontrib>Ma, Eunsook</creatorcontrib><creatorcontrib>Kwon, Kwang-il</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pharmaceutical and biomedical analysis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kang, Wonku</au><au>Jeong, Ji-Hoon</au><au>Ma, Eunsook</au><au>Kwon, Kwang-il</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Simple and sensitive determination of menatetrenone and its epoxide metabolite in human plasma</atitle><jtitle>Journal of pharmaceutical and biomedical analysis</jtitle><addtitle>J Pharm Biomed Anal</addtitle><date>2007-09-03</date><risdate>2007</risdate><volume>44</volume><issue>5</issue><spage>1178</spage><epage>1182</epage><pages>1178-1182</pages><issn>0731-7085</issn><eissn>1873-264X</eissn><coden>JPBADA</coden><abstract>A simple and rapid quantification method was developed for determining menatetrenone and its epoxide metabolite in human plasma. After a simple protein precipitation with methanol, the analytes were chromatographed on a reversed-phase C
18 column and detected by LC/MS/MS with atmospheric pressure chemical ionization. The coefficient of variation of the assay precision was less than 10.1%, and the accuracy ranged from 98.0 to 106.5%. The limit of detection of menatetrenone and its epoxide was 0.5 and 0.2
ng/ml, respectively. This method was used to simultaneously measure the plasma concentration of menatetrenone and its epoxide metabolite from healthy subjects after a single 30
mg oral dose of menatetrenone.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>17561362</pmid><doi>10.1016/j.jpba.2007.04.028</doi><tpages>5</tpages></addata></record> |
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| ispartof | Journal of pharmaceutical and biomedical analysis, 2007-09, Vol.44 (5), p.1178-1182 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Analysis Analytical, structural and metabolic biochemistry Biological and medical sciences Chromatography, Liquid - methods Epoxide metabolite Epoxy Compounds - blood Fundamental and applied biological sciences. Psychology General pharmacology Hemostatics - blood Hemostatics - metabolism Humans LC/MS/MS Medical sciences Menatetrenone Methanol - chemistry Pharmacology. Drug treatments Reference Standards Reproducibility of Results Sensitivity and Specificity Solvents - chemistry Tandem Mass Spectrometry - methods Time Factors Vitamin K 2 - analogs & derivatives Vitamin K 2 - blood Vitamin K 2 - metabolism |
| title | Simple and sensitive determination of menatetrenone and its epoxide metabolite in human plasma |
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