Responses of the diaphragm to transcranial magnetic stimulation during wake and sleep in humans
The human ventilation depends on bulbospinal and corticospinal commands. This study assessed their interactions in five healthy volunteers (two men, age 25–35) through the description of diaphragm and abductor pollicis brevis (APB) motor potentials (DiMEPs, abpMEPs) evoked by transcranial magnetic s...
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| Veröffentlicht in: | Respiratory physiology & neurobiology 2006-12, Vol.154 (3), p.406-418 |
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| creator | Mehiri, Selma Straus, Christian Arnulf, Isabelle Attali, Valérie Zelter, Marc Derenne, Jean-Philippe Similowski, Thomas |
| description | The human ventilation depends on bulbospinal and corticospinal commands. This study assessed their interactions in five healthy volunteers (two men, age 25–35) through the description of diaphragm and abductor pollicis brevis (APB) motor potentials (DiMEPs, abpMEPs) evoked by transcranial magnetic stimulation (TMS) during relaxed expiration and tidal inspiration and during wake and sleep. NREM decreased corticospinal excitability and REM further did so, for both the diaphragm and the APB. During wake, inspiration shortened supine DiMEPs latencies (expiration 18.56
±
1.90
ms; inspiration 17.37
±
1.48
ms,
P
<
0.001). This persisted during sleep in an augmented manner (expiration: 21.05
±
1.39
ms; inspiration 18.69
±
1.17
ms,
P
=
0.002). Inspiration had no effect on apbMEPs during wake and sleep. In conclusion: (1) the tidal bulbospinal input to phrenic motoneurones is sufficient to modulate the throughput of the corticospinal pathway to these neurones; (2) this modulation is best seen after the sleep related removal of corticospinal and/or afferent inputs. |
| doi_str_mv | 10.1016/j.resp.2005.12.003 |
| format | Article |
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±
1.90
ms; inspiration 17.37
±
1.48
ms,
P
<
0.001). This persisted during sleep in an augmented manner (expiration: 21.05
±
1.39
ms; inspiration 18.69
±
1.17
ms,
P
=
0.002). Inspiration had no effect on apbMEPs during wake and sleep. In conclusion: (1) the tidal bulbospinal input to phrenic motoneurones is sufficient to modulate the throughput of the corticospinal pathway to these neurones; (2) this modulation is best seen after the sleep related removal of corticospinal and/or afferent inputs.</description><identifier>ISSN: 1569-9048</identifier><identifier>EISSN: 1878-1519</identifier><identifier>DOI: 10.1016/j.resp.2005.12.003</identifier><identifier>PMID: 16406377</identifier><language>eng</language><publisher>Amsterdarm: Elsevier B.V</publisher><subject>Adult ; Biological and medical sciences ; Breathing control ; Chemosensitivity ; Diaphragm ; Diaphragm - physiology ; Evoked Potentials, Motor ; Exhalation - physiology ; Female ; Fundamental and applied biological sciences. Psychology ; Humans ; Inhalation - physiology ; Male ; Muscle, Skeletal - physiology ; Pyramidal Tracts - physiology ; Reaction Time ; Sleep ; Sleep - physiology ; Sleep Stages - physiology ; Thumb ; Transcranial Magnetic Stimulation ; Vertebrates: respiratory system ; Wakefulness - physiology</subject><ispartof>Respiratory physiology & neurobiology, 2006-12, Vol.154 (3), p.406-418</ispartof><rights>2006 Elsevier B.V.</rights><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c384t-d9ca11d9ba9e1cb7779745f0eff75b35bb4bea4cced0028b91886cd356c91bf53</citedby><cites>FETCH-LOGICAL-c384t-d9ca11d9ba9e1cb7779745f0eff75b35bb4bea4cced0028b91886cd356c91bf53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.resp.2005.12.003$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18337349$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16406377$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mehiri, Selma</creatorcontrib><creatorcontrib>Straus, Christian</creatorcontrib><creatorcontrib>Arnulf, Isabelle</creatorcontrib><creatorcontrib>Attali, Valérie</creatorcontrib><creatorcontrib>Zelter, Marc</creatorcontrib><creatorcontrib>Derenne, Jean-Philippe</creatorcontrib><creatorcontrib>Similowski, Thomas</creatorcontrib><title>Responses of the diaphragm to transcranial magnetic stimulation during wake and sleep in humans</title><title>Respiratory physiology & neurobiology</title><addtitle>Respir Physiol Neurobiol</addtitle><description>The human ventilation depends on bulbospinal and corticospinal commands. This study assessed their interactions in five healthy volunteers (two men, age 25–35) through the description of diaphragm and abductor pollicis brevis (APB) motor potentials (DiMEPs, abpMEPs) evoked by transcranial magnetic stimulation (TMS) during relaxed expiration and tidal inspiration and during wake and sleep. NREM decreased corticospinal excitability and REM further did so, for both the diaphragm and the APB. During wake, inspiration shortened supine DiMEPs latencies (expiration 18.56
±
1.90
ms; inspiration 17.37
±
1.48
ms,
P
<
0.001). This persisted during sleep in an augmented manner (expiration: 21.05
±
1.39
ms; inspiration 18.69
±
1.17
ms,
P
=
0.002). Inspiration had no effect on apbMEPs during wake and sleep. In conclusion: (1) the tidal bulbospinal input to phrenic motoneurones is sufficient to modulate the throughput of the corticospinal pathway to these neurones; (2) this modulation is best seen after the sleep related removal of corticospinal and/or afferent inputs.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Breathing control</subject><subject>Chemosensitivity</subject><subject>Diaphragm</subject><subject>Diaphragm - physiology</subject><subject>Evoked Potentials, Motor</subject><subject>Exhalation - physiology</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Inhalation - physiology</subject><subject>Male</subject><subject>Muscle, Skeletal - physiology</subject><subject>Pyramidal Tracts - physiology</subject><subject>Reaction Time</subject><subject>Sleep</subject><subject>Sleep - physiology</subject><subject>Sleep Stages - physiology</subject><subject>Thumb</subject><subject>Transcranial Magnetic Stimulation</subject><subject>Vertebrates: respiratory system</subject><subject>Wakefulness - physiology</subject><issn>1569-9048</issn><issn>1878-1519</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMFu1DAQhi0EoqXwAhyQL_SW4ImT2Ja4oIpSpEpIqJwt25nsekmcYDugvj1e7Uq99eLx4ft_zXyEvAdWA4P-06GOmNa6YayroakZ4y_IJUghK-hAvSz_rleVYq28IG9SOjAGAgR_TS6gb1nPhbgk-mepWELCRJeR5j3SwZt1H81upnmhOZqQXHm8mehsdgGzdzRlP2-TyX4JdNiiDzv6z_xGasJA04S4Uh_ofptL9i15NZop4bvzvCK_br8-3NxV9z--fb_5cl85LttcDcoZgEFZoxCcFUIo0XYjw3EUneWdta1F0zqHA2ONtAqk7N3Au94psGPHr8j1qXeNy58NU9azTw6nyQRctqR7CUL0AAVsTqCLS0oRR71GP5v4qIHpo1Z90Eet-qhVQ6OL1hL6cG7f7IzDU-TssQAfz4BJzkxjMeZ8euIk54K3qnCfTxwWF389Rp2cx1DO8hFd1sPin9vjP0lCmDA</recordid><startdate>20061201</startdate><enddate>20061201</enddate><creator>Mehiri, Selma</creator><creator>Straus, Christian</creator><creator>Arnulf, Isabelle</creator><creator>Attali, Valérie</creator><creator>Zelter, Marc</creator><creator>Derenne, Jean-Philippe</creator><creator>Similowski, Thomas</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20061201</creationdate><title>Responses of the diaphragm to transcranial magnetic stimulation during wake and sleep in humans</title><author>Mehiri, Selma ; Straus, Christian ; Arnulf, Isabelle ; Attali, Valérie ; Zelter, Marc ; Derenne, Jean-Philippe ; Similowski, Thomas</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c384t-d9ca11d9ba9e1cb7779745f0eff75b35bb4bea4cced0028b91886cd356c91bf53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Breathing control</topic><topic>Chemosensitivity</topic><topic>Diaphragm</topic><topic>Diaphragm - physiology</topic><topic>Evoked Potentials, Motor</topic><topic>Exhalation - physiology</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Inhalation - physiology</topic><topic>Male</topic><topic>Muscle, Skeletal - physiology</topic><topic>Pyramidal Tracts - physiology</topic><topic>Reaction Time</topic><topic>Sleep</topic><topic>Sleep - physiology</topic><topic>Sleep Stages - physiology</topic><topic>Thumb</topic><topic>Transcranial Magnetic Stimulation</topic><topic>Vertebrates: respiratory system</topic><topic>Wakefulness - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mehiri, Selma</creatorcontrib><creatorcontrib>Straus, Christian</creatorcontrib><creatorcontrib>Arnulf, Isabelle</creatorcontrib><creatorcontrib>Attali, Valérie</creatorcontrib><creatorcontrib>Zelter, Marc</creatorcontrib><creatorcontrib>Derenne, Jean-Philippe</creatorcontrib><creatorcontrib>Similowski, Thomas</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Respiratory physiology & neurobiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mehiri, Selma</au><au>Straus, Christian</au><au>Arnulf, Isabelle</au><au>Attali, Valérie</au><au>Zelter, Marc</au><au>Derenne, Jean-Philippe</au><au>Similowski, Thomas</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Responses of the diaphragm to transcranial magnetic stimulation during wake and sleep in humans</atitle><jtitle>Respiratory physiology & neurobiology</jtitle><addtitle>Respir Physiol Neurobiol</addtitle><date>2006-12-01</date><risdate>2006</risdate><volume>154</volume><issue>3</issue><spage>406</spage><epage>418</epage><pages>406-418</pages><issn>1569-9048</issn><eissn>1878-1519</eissn><abstract>The human ventilation depends on bulbospinal and corticospinal commands. This study assessed their interactions in five healthy volunteers (two men, age 25–35) through the description of diaphragm and abductor pollicis brevis (APB) motor potentials (DiMEPs, abpMEPs) evoked by transcranial magnetic stimulation (TMS) during relaxed expiration and tidal inspiration and during wake and sleep. NREM decreased corticospinal excitability and REM further did so, for both the diaphragm and the APB. During wake, inspiration shortened supine DiMEPs latencies (expiration 18.56
±
1.90
ms; inspiration 17.37
±
1.48
ms,
P
<
0.001). This persisted during sleep in an augmented manner (expiration: 21.05
±
1.39
ms; inspiration 18.69
±
1.17
ms,
P
=
0.002). Inspiration had no effect on apbMEPs during wake and sleep. In conclusion: (1) the tidal bulbospinal input to phrenic motoneurones is sufficient to modulate the throughput of the corticospinal pathway to these neurones; (2) this modulation is best seen after the sleep related removal of corticospinal and/or afferent inputs.</abstract><cop>Amsterdarm</cop><pub>Elsevier B.V</pub><pmid>16406377</pmid><doi>10.1016/j.resp.2005.12.003</doi><tpages>13</tpages></addata></record> |
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| ispartof | Respiratory physiology & neurobiology, 2006-12, Vol.154 (3), p.406-418 |
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| language | eng |
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| subjects | Adult Biological and medical sciences Breathing control Chemosensitivity Diaphragm Diaphragm - physiology Evoked Potentials, Motor Exhalation - physiology Female Fundamental and applied biological sciences. Psychology Humans Inhalation - physiology Male Muscle, Skeletal - physiology Pyramidal Tracts - physiology Reaction Time Sleep Sleep - physiology Sleep Stages - physiology Thumb Transcranial Magnetic Stimulation Vertebrates: respiratory system Wakefulness - physiology |
| title | Responses of the diaphragm to transcranial magnetic stimulation during wake and sleep in humans |
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