Long-term monitoring of transplanted islets using positron emission tomography

Islet transplantation can restore glucose homeostasis in those with type 1 diabetes; however, most recipients eventually lose graft function. A noninvasive method to monitor islets following transplantation would enable assessment of their survival and aid the development of therapeutics to prolong...

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Veröffentlicht in:	Molecular therapy 2006-12, Vol.14 (6), p.851-856
Hauptverfasser:	Lu, Yuxin, Dang, Hoa, Middleton, Blake, Campbell-Thompson, Martha, Atkinson, Mark A, Gambhir, Sanjiv Sam, Tian, Jide, Kaufman, Daniel L
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviruses Animals Cells, Cultured Diabetes Diabetes Mellitus, Type 1 - genetics Diabetes Mellitus, Type 1 - physiopathology Diabetes Mellitus, Type 1 - therapy Genes Genetic Vectors - genetics Glucose Graft Survival - genetics Graft Survival - physiology Herpesvirus 1, Human - enzymology Homeostasis Humans Insulin Islets of Langerhans - cytology Islets of Langerhans - diagnostic imaging Islets of Langerhans - metabolism Islets of Langerhans Transplantation - diagnostic imaging Islets of Langerhans Transplantation - methods Kinases Lentivirus - genetics Male Mice Mice, Inbred NOD Mutation - genetics Positron-Emission Tomography - methods Thymidine Kinase - genetics Thymidine Kinase - metabolism Time Factors Tomography Transfection Transplantation, Heterologous Transplants & implants
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