Microsomal glutathione S-transferase gene polymorphisms and colorectal cancer risk in a Han Chinese population
Glutathione S-transferases (GSTs) are phase II detoxification enzymes. Human GSTs have been classified into cytosolic, mitochondrial, and microsomal families. Several studies reported the association of colorectal cancer (CRC) risk with the genetic polymorphisms of cytosolic GSTs. The microsomal GST...
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| Veröffentlicht in: | International journal of colorectal disease 2007-10, Vol.22 (10), p.1185-1194 |
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| creator | HAO ZHANG LIAO, Ling-Hong CAI, Jian-Hua LUNG, Maria Li TAI, Susan S. W WU, Madeline LIU, Shuk-Ming LAU, Kwok-Wai LAI, Albert Kai-Cheong ZHANG, Jin-Hui QI WANG CHEN, Xiao-Qian WEI WEI HUA LIU |
| description | Glutathione S-transferases (GSTs) are phase II detoxification enzymes. Human GSTs have been classified into cytosolic, mitochondrial, and microsomal families. Several studies reported the association of colorectal cancer (CRC) risk with the genetic polymorphisms of cytosolic GSTs. The microsomal GSTs are structurally distinct but functionally similar to cytosolic GSTs; their association with CRC has not been reported. In this report, we summarized the result of a case-control study aimed at investigating the association of MGST1 gene locus polymorphisms with CRC risk among Han Chinese.
Three hundred and seventy-two healthy controls and 238 sporadic CRC patients participated in this study. DNA resequencing was conducted for the 3.4 kb genomic DNA region containing the promoter, exons, exon-intron junctions, and the 5' and 3' untranslated regions.
We detected 13 single nucleotide polymorphisms (SNPs) including four novel SNPs not reported in database/literature. The gene shows a much higher nucleotide diversity than most human genes. The linkage and recombination analysis revealed 24 common haplotypes (13% > or = freq > or = 1%) and identified extensive intragenic recombination throughout the MGST1 locus (R = 81.8). Significant CRC association (P < or = 0.005) was not detected for each individual SNP. However, SNPs 102G>A and 16416G>A reached a marginal level of statistical significance with P values of 0.016 and 0.078, respectively. A combined genotype analysis detected a statistically significant CRC association for individuals carrying 102G>A/16416G>A (GG/GG) genotype (adjusted OR, 1.682; 95% confidence interval (CI), 1.177-2.404; P = 0.004). Consistent with the results of genotype analysis, the GG haplotype (102G>A/16416G>A) with two risk alleles was associated with a significantly higher CRC risk comparing with the haplotypes with one or no risk allele (adjusted OR 1.744; 95% CI 1.309-2.322; P = 0.0001).
The results suggest that MGST1 polymorphisms may contribute to CRC risk among Han Chinese. |
| doi_str_mv | 10.1007/s00384-007-0308-9 |
| format | Article |
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Three hundred and seventy-two healthy controls and 238 sporadic CRC patients participated in this study. DNA resequencing was conducted for the 3.4 kb genomic DNA region containing the promoter, exons, exon-intron junctions, and the 5' and 3' untranslated regions.
We detected 13 single nucleotide polymorphisms (SNPs) including four novel SNPs not reported in database/literature. The gene shows a much higher nucleotide diversity than most human genes. The linkage and recombination analysis revealed 24 common haplotypes (13% > or = freq > or = 1%) and identified extensive intragenic recombination throughout the MGST1 locus (R = 81.8). Significant CRC association (P < or = 0.005) was not detected for each individual SNP. However, SNPs 102G>A and 16416G>A reached a marginal level of statistical significance with P values of 0.016 and 0.078, respectively. A combined genotype analysis detected a statistically significant CRC association for individuals carrying 102G>A/16416G>A (GG/GG) genotype (adjusted OR, 1.682; 95% confidence interval (CI), 1.177-2.404; P = 0.004). Consistent with the results of genotype analysis, the GG haplotype (102G>A/16416G>A) with two risk alleles was associated with a significantly higher CRC risk comparing with the haplotypes with one or no risk allele (adjusted OR 1.744; 95% CI 1.309-2.322; P = 0.0001).
The results suggest that MGST1 polymorphisms may contribute to CRC risk among Han Chinese.</description><identifier>ISSN: 0179-1958</identifier><identifier>EISSN: 1432-1262</identifier><identifier>DOI: 10.1007/s00384-007-0308-9</identifier><identifier>PMID: 17483957</identifier><identifier>CODEN: IJCDE6</identifier><language>eng</language><publisher>Heidelberg: Springer</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Asian Continental Ancestry Group - genetics ; Base Sequence ; Biological and medical sciences ; Case-Control Studies ; Colorectal Neoplasms - enzymology ; Colorectal Neoplasms - genetics ; DNA ; Female ; Gastroenterology. Liver. Pancreas. Abdomen ; Gene Expression Regulation ; Genetic Predisposition to Disease ; Genotype ; Glutathione Transferase - genetics ; Humans ; Male ; Medical sciences ; Microsomes - enzymology ; Middle Aged ; Polymorphism, Single Nucleotide - genetics ; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus ; Tumors</subject><ispartof>International journal of colorectal disease, 2007-10, Vol.22 (10), p.1185-1194</ispartof><rights>2007 INIST-CNRS</rights><rights>Springer-Verlag 2007</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c356t-b787143a099ac12257634dcb757eadd6e045718d28e9a48179cb91ffbdc4fc883</citedby><cites>FETCH-LOGICAL-c356t-b787143a099ac12257634dcb757eadd6e045718d28e9a48179cb91ffbdc4fc883</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19069509$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17483957$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>HAO ZHANG</creatorcontrib><creatorcontrib>LIAO, Ling-Hong</creatorcontrib><creatorcontrib>CAI, Jian-Hua</creatorcontrib><creatorcontrib>LUNG, Maria Li</creatorcontrib><creatorcontrib>TAI, Susan S. W</creatorcontrib><creatorcontrib>WU, Madeline</creatorcontrib><creatorcontrib>LIU, Shuk-Ming</creatorcontrib><creatorcontrib>LAU, Kwok-Wai</creatorcontrib><creatorcontrib>LAI, Albert Kai-Cheong</creatorcontrib><creatorcontrib>ZHANG, Jin-Hui</creatorcontrib><creatorcontrib>QI WANG</creatorcontrib><creatorcontrib>CHEN, Xiao-Qian</creatorcontrib><creatorcontrib>WEI WEI</creatorcontrib><creatorcontrib>HUA LIU</creatorcontrib><title>Microsomal glutathione S-transferase gene polymorphisms and colorectal cancer risk in a Han Chinese population</title><title>International journal of colorectal disease</title><addtitle>Int J Colorectal Dis</addtitle><description>Glutathione S-transferases (GSTs) are phase II detoxification enzymes. Human GSTs have been classified into cytosolic, mitochondrial, and microsomal families. Several studies reported the association of colorectal cancer (CRC) risk with the genetic polymorphisms of cytosolic GSTs. The microsomal GSTs are structurally distinct but functionally similar to cytosolic GSTs; their association with CRC has not been reported. In this report, we summarized the result of a case-control study aimed at investigating the association of MGST1 gene locus polymorphisms with CRC risk among Han Chinese.
Three hundred and seventy-two healthy controls and 238 sporadic CRC patients participated in this study. DNA resequencing was conducted for the 3.4 kb genomic DNA region containing the promoter, exons, exon-intron junctions, and the 5' and 3' untranslated regions.
We detected 13 single nucleotide polymorphisms (SNPs) including four novel SNPs not reported in database/literature. The gene shows a much higher nucleotide diversity than most human genes. The linkage and recombination analysis revealed 24 common haplotypes (13% > or = freq > or = 1%) and identified extensive intragenic recombination throughout the MGST1 locus (R = 81.8). Significant CRC association (P < or = 0.005) was not detected for each individual SNP. However, SNPs 102G>A and 16416G>A reached a marginal level of statistical significance with P values of 0.016 and 0.078, respectively. A combined genotype analysis detected a statistically significant CRC association for individuals carrying 102G>A/16416G>A (GG/GG) genotype (adjusted OR, 1.682; 95% confidence interval (CI), 1.177-2.404; P = 0.004). Consistent with the results of genotype analysis, the GG haplotype (102G>A/16416G>A) with two risk alleles was associated with a significantly higher CRC risk comparing with the haplotypes with one or no risk allele (adjusted OR 1.744; 95% CI 1.309-2.322; P = 0.0001).
The results suggest that MGST1 polymorphisms may contribute to CRC risk among Han Chinese.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Asian Continental Ancestry Group - genetics</subject><subject>Base Sequence</subject><subject>Biological and medical sciences</subject><subject>Case-Control Studies</subject><subject>Colorectal Neoplasms - enzymology</subject><subject>Colorectal Neoplasms - genetics</subject><subject>DNA</subject><subject>Female</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Gene Expression Regulation</subject><subject>Genetic Predisposition to Disease</subject><subject>Genotype</subject><subject>Glutathione Transferase - genetics</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Microsomes - enzymology</subject><subject>Middle Aged</subject><subject>Polymorphism, Single Nucleotide - genetics</subject><subject>Stomach. 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W ; WU, Madeline ; LIU, Shuk-Ming ; LAU, Kwok-Wai ; LAI, Albert Kai-Cheong ; ZHANG, Jin-Hui ; QI WANG ; CHEN, Xiao-Qian ; WEI WEI ; HUA LIU</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-b787143a099ac12257634dcb757eadd6e045718d28e9a48179cb91ffbdc4fc883</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Asian Continental Ancestry Group - genetics</topic><topic>Base Sequence</topic><topic>Biological and medical sciences</topic><topic>Case-Control Studies</topic><topic>Colorectal Neoplasms - enzymology</topic><topic>Colorectal Neoplasms - genetics</topic><topic>DNA</topic><topic>Female</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Gene Expression Regulation</topic><topic>Genetic Predisposition to Disease</topic><topic>Genotype</topic><topic>Glutathione Transferase - genetics</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Microsomes - enzymology</topic><topic>Middle Aged</topic><topic>Polymorphism, Single Nucleotide - genetics</topic><topic>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>HAO ZHANG</creatorcontrib><creatorcontrib>LIAO, Ling-Hong</creatorcontrib><creatorcontrib>CAI, Jian-Hua</creatorcontrib><creatorcontrib>LUNG, Maria Li</creatorcontrib><creatorcontrib>TAI, Susan S. W</creatorcontrib><creatorcontrib>WU, Madeline</creatorcontrib><creatorcontrib>LIU, Shuk-Ming</creatorcontrib><creatorcontrib>LAU, Kwok-Wai</creatorcontrib><creatorcontrib>LAI, Albert Kai-Cheong</creatorcontrib><creatorcontrib>ZHANG, Jin-Hui</creatorcontrib><creatorcontrib>QI WANG</creatorcontrib><creatorcontrib>CHEN, Xiao-Qian</creatorcontrib><creatorcontrib>WEI WEI</creatorcontrib><creatorcontrib>HUA LIU</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of colorectal disease</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>HAO ZHANG</au><au>LIAO, Ling-Hong</au><au>CAI, Jian-Hua</au><au>LUNG, Maria Li</au><au>TAI, Susan S. W</au><au>WU, Madeline</au><au>LIU, Shuk-Ming</au><au>LAU, Kwok-Wai</au><au>LAI, Albert Kai-Cheong</au><au>ZHANG, Jin-Hui</au><au>QI WANG</au><au>CHEN, Xiao-Qian</au><au>WEI WEI</au><au>HUA LIU</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Microsomal glutathione S-transferase gene polymorphisms and colorectal cancer risk in a Han Chinese population</atitle><jtitle>International journal of colorectal disease</jtitle><addtitle>Int J Colorectal Dis</addtitle><date>2007-10-01</date><risdate>2007</risdate><volume>22</volume><issue>10</issue><spage>1185</spage><epage>1194</epage><pages>1185-1194</pages><issn>0179-1958</issn><eissn>1432-1262</eissn><coden>IJCDE6</coden><abstract>Glutathione S-transferases (GSTs) are phase II detoxification enzymes. Human GSTs have been classified into cytosolic, mitochondrial, and microsomal families. Several studies reported the association of colorectal cancer (CRC) risk with the genetic polymorphisms of cytosolic GSTs. The microsomal GSTs are structurally distinct but functionally similar to cytosolic GSTs; their association with CRC has not been reported. In this report, we summarized the result of a case-control study aimed at investigating the association of MGST1 gene locus polymorphisms with CRC risk among Han Chinese.
Three hundred and seventy-two healthy controls and 238 sporadic CRC patients participated in this study. DNA resequencing was conducted for the 3.4 kb genomic DNA region containing the promoter, exons, exon-intron junctions, and the 5' and 3' untranslated regions.
We detected 13 single nucleotide polymorphisms (SNPs) including four novel SNPs not reported in database/literature. The gene shows a much higher nucleotide diversity than most human genes. The linkage and recombination analysis revealed 24 common haplotypes (13% > or = freq > or = 1%) and identified extensive intragenic recombination throughout the MGST1 locus (R = 81.8). Significant CRC association (P < or = 0.005) was not detected for each individual SNP. However, SNPs 102G>A and 16416G>A reached a marginal level of statistical significance with P values of 0.016 and 0.078, respectively. A combined genotype analysis detected a statistically significant CRC association for individuals carrying 102G>A/16416G>A (GG/GG) genotype (adjusted OR, 1.682; 95% confidence interval (CI), 1.177-2.404; P = 0.004). Consistent with the results of genotype analysis, the GG haplotype (102G>A/16416G>A) with two risk alleles was associated with a significantly higher CRC risk comparing with the haplotypes with one or no risk allele (adjusted OR 1.744; 95% CI 1.309-2.322; P = 0.0001).
The results suggest that MGST1 polymorphisms may contribute to CRC risk among Han Chinese.</abstract><cop>Heidelberg</cop><cop>Berlin</cop><pub>Springer</pub><pmid>17483957</pmid><doi>10.1007/s00384-007-0308-9</doi><tpages>10</tpages></addata></record> |
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| subjects | Adult Aged Aged, 80 and over Asian Continental Ancestry Group - genetics Base Sequence Biological and medical sciences Case-Control Studies Colorectal Neoplasms - enzymology Colorectal Neoplasms - genetics DNA Female Gastroenterology. Liver. Pancreas. Abdomen Gene Expression Regulation Genetic Predisposition to Disease Genotype Glutathione Transferase - genetics Humans Male Medical sciences Microsomes - enzymology Middle Aged Polymorphism, Single Nucleotide - genetics Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Tumors |
| title | Microsomal glutathione S-transferase gene polymorphisms and colorectal cancer risk in a Han Chinese population |
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