T helper type 1 cytokines and keratinocyte growth factor play a critical role in pseudoepitheliomatous hyperplasia initiation during cutaneous leishmaniasis

Pseudoepitheliomatous hyperplasia (PEH) is an exuberant proliferation of the epidermis. The underlying mechanism(s) that lead to PEH have not been completely elucidated. Here, we characterize PEH during the healing stages of cutaneous leishmanial ulcers in mice. During experimental cutaneous leishma...

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Veröffentlicht in:	Archives of Dermatological Research 2007-09, Vol.299 (7), p.315-325
Hauptverfasser:	AKILOV, Oleg E, DONOVAN, Michael J, STEPINAC, Thomas, CARTER, Cristina R, WHITCOMB, James P, HASAN, Tayyaba, MCDOWELL, Mary Ann
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Collagen - analysis Cutaneous leishmaniasis Cytokines Dermatology Dermis Epidermis Epidermis - pathology Epithelial Cells - pathology Female Fibroblast Growth Factor 7 - analysis Fibroblast Growth Factor 7 - genetics Fibroblast Growth Factor 7 - physiology Growth factors Human protozoal diseases Hyperplasia Infectious diseases Interferon-gamma - physiology Keratinocyte growth factor Leishmaniasis, Cutaneous - pathology Leshmaniasis Lymphocytes T Macrophages Medical sciences Mice Mice, Inbred BALB C Parasitic diseases Protozoal diseases Receptor, Fibroblast Growth Factor, Type 2 - analysis Th1 Cells - immunology Tumor Necrosis Factor-alpha - physiology Tumor necrosis factor-α Ulcers γ-Interferon
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