Use of (99m)Tc-sulesomab for the diagnosis of prosthesis infection after total joint arthroplasty
This study aimed to evaluate the diagnostic efficacy of antigranulocyte scintigraphy using the antibody fragment (99m)Tc-sulesomab (LeukoScan) for the diagnosis of prosthesis infection in patients with total hip or knee arthroplasty. The results from 19 patients with suspected total joint arthroplas...
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| Veröffentlicht in: | Journal of international medical research 2007-07, Vol.35 (4), p.474-481 |
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| container_title | Journal of international medical research |
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| creator | Pakos, E E Fotopoulos, A D Stafilas, K S Gavriilidis, I Al Boukarali, G Tsiouris, S Xenakis, T A |
| description | This study aimed to evaluate the diagnostic efficacy of antigranulocyte scintigraphy using the antibody fragment (99m)Tc-sulesomab (LeukoScan) for the diagnosis of prosthesis infection in patients with total hip or knee arthroplasty. The results from 19 patients with suspected total joint arthroplasty infection who had undergone a three-phase bone scan and a subsequent examination with (99m)Tc-sulesomab during a 1-year period were reviewed. Twelve patients were shown to have prosthesis infection on culture of aspirated synovial fluid or intra-operative samples. The overall sensitivity, specificity, positive and negative predictive values, and diagnostic accuracy for (99m)Tc-sulesomab were 75%, 86%, 90%, 66% and 79%, respectively, compared with 54%, 83%, 88%, 45% and 63%, respectively, for the three-phase bone scan. This study showed that (99m)Tc-sulesomab had good diagnostic value for the detection of prosthesis infection. The combination of (99m)Tc-sulesomab with other laboratory or imaging examinations may improve diagnostic performance in prosthesis infection and should be investigated further. |
| doi_str_mv | 10.1177/147323000703500406 |
| format | Article |
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The results from 19 patients with suspected total joint arthroplasty infection who had undergone a three-phase bone scan and a subsequent examination with (99m)Tc-sulesomab during a 1-year period were reviewed. Twelve patients were shown to have prosthesis infection on culture of aspirated synovial fluid or intra-operative samples. The overall sensitivity, specificity, positive and negative predictive values, and diagnostic accuracy for (99m)Tc-sulesomab were 75%, 86%, 90%, 66% and 79%, respectively, compared with 54%, 83%, 88%, 45% and 63%, respectively, for the three-phase bone scan. This study showed that (99m)Tc-sulesomab had good diagnostic value for the detection of prosthesis infection. The combination of (99m)Tc-sulesomab with other laboratory or imaging examinations may improve diagnostic performance in prosthesis infection and should be investigated further.</description><identifier>ISSN: 0300-0605</identifier><identifier>DOI: 10.1177/147323000703500406</identifier><identifier>PMID: 17697524</identifier><language>eng</language><publisher>England</publisher><subject>Adult ; Antibodies, Monoclonal - immunology ; Antibodies, Monoclonal, Murine-Derived ; Arthroplasty, Replacement ; Female ; Hip Joint - diagnostic imaging ; Hip Prosthesis - adverse effects ; Hospitals, Teaching ; Humans ; Knee Joint - diagnostic imaging ; Knee Prosthesis - adverse effects ; Positron-Emission Tomography ; Prosthesis-Related Infections - diagnostic imaging ; Prosthesis-Related Infections - etiology ; Prosthesis-Related Infections - pathology ; Radiopharmaceuticals ; Reproducibility of Results ; Sensitivity and Specificity ; Technetium Tc 99m Medronate</subject><ispartof>Journal of international medical research, 2007-07, Vol.35 (4), p.474-481</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17697524$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pakos, E E</creatorcontrib><creatorcontrib>Fotopoulos, A D</creatorcontrib><creatorcontrib>Stafilas, K S</creatorcontrib><creatorcontrib>Gavriilidis, I</creatorcontrib><creatorcontrib>Al Boukarali, G</creatorcontrib><creatorcontrib>Tsiouris, S</creatorcontrib><creatorcontrib>Xenakis, T A</creatorcontrib><title>Use of (99m)Tc-sulesomab for the diagnosis of prosthesis infection after total joint arthroplasty</title><title>Journal of international medical research</title><addtitle>J Int Med Res</addtitle><description>This study aimed to evaluate the diagnostic efficacy of antigranulocyte scintigraphy using the antibody fragment (99m)Tc-sulesomab (LeukoScan) for the diagnosis of prosthesis infection in patients with total hip or knee arthroplasty. The results from 19 patients with suspected total joint arthroplasty infection who had undergone a three-phase bone scan and a subsequent examination with (99m)Tc-sulesomab during a 1-year period were reviewed. Twelve patients were shown to have prosthesis infection on culture of aspirated synovial fluid or intra-operative samples. The overall sensitivity, specificity, positive and negative predictive values, and diagnostic accuracy for (99m)Tc-sulesomab were 75%, 86%, 90%, 66% and 79%, respectively, compared with 54%, 83%, 88%, 45% and 63%, respectively, for the three-phase bone scan. This study showed that (99m)Tc-sulesomab had good diagnostic value for the detection of prosthesis infection. The combination of (99m)Tc-sulesomab with other laboratory or imaging examinations may improve diagnostic performance in prosthesis infection and should be investigated further.</description><subject>Adult</subject><subject>Antibodies, Monoclonal - immunology</subject><subject>Antibodies, Monoclonal, Murine-Derived</subject><subject>Arthroplasty, Replacement</subject><subject>Female</subject><subject>Hip Joint - diagnostic imaging</subject><subject>Hip Prosthesis - adverse effects</subject><subject>Hospitals, Teaching</subject><subject>Humans</subject><subject>Knee Joint - diagnostic imaging</subject><subject>Knee Prosthesis - adverse effects</subject><subject>Positron-Emission Tomography</subject><subject>Prosthesis-Related Infections - diagnostic imaging</subject><subject>Prosthesis-Related Infections - etiology</subject><subject>Prosthesis-Related Infections - pathology</subject><subject>Radiopharmaceuticals</subject><subject>Reproducibility of Results</subject><subject>Sensitivity and Specificity</subject><subject>Technetium Tc 99m Medronate</subject><issn>0300-0605</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1kD1PwzAQhj2AaCn8AQbkCcEQuLNjOxkR4kuqxNLOkZ3YNFUSh9gZ-u9xRVnudI8evXp1hNwgPCIq9YS54owDgAIuAHKQZ2QJCWQgQSzIZQj7hJkU7IIsUMlSCZYvid4GS72j92XZP2zqLMydDb7Xhjo_0biztGn19-BDG47aOPmQ4PFqB2fr2PqBahdtcn3UHd37dohUT3E3-bHTIR6uyLnTXbDXp70i27fXzctHtv56_3x5XmcjsjxmRWE0a0pkJucgbIHQSO5YLRphjElDW5RCqQIUWsFK2XCHijnklisGmq_I3V9u6vgz2xCrvg217To9WD-HShaockBM4u1JnE1vm2qc2l5Ph-r_KfwX-ptibg</recordid><startdate>200707</startdate><enddate>200707</enddate><creator>Pakos, E E</creator><creator>Fotopoulos, A D</creator><creator>Stafilas, K S</creator><creator>Gavriilidis, I</creator><creator>Al Boukarali, G</creator><creator>Tsiouris, S</creator><creator>Xenakis, T A</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>200707</creationdate><title>Use of (99m)Tc-sulesomab for the diagnosis of prosthesis infection after total joint arthroplasty</title><author>Pakos, E E ; Fotopoulos, A D ; Stafilas, K S ; Gavriilidis, I ; Al Boukarali, G ; Tsiouris, S ; Xenakis, T A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p124t-88ba2d912b4305e810d63f2c5d5bbbd5bae165778071e5296d3f172f13e3720a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adult</topic><topic>Antibodies, Monoclonal - immunology</topic><topic>Antibodies, Monoclonal, Murine-Derived</topic><topic>Arthroplasty, Replacement</topic><topic>Female</topic><topic>Hip Joint - diagnostic imaging</topic><topic>Hip Prosthesis - adverse effects</topic><topic>Hospitals, Teaching</topic><topic>Humans</topic><topic>Knee Joint - diagnostic imaging</topic><topic>Knee Prosthesis - adverse effects</topic><topic>Positron-Emission Tomography</topic><topic>Prosthesis-Related Infections - diagnostic imaging</topic><topic>Prosthesis-Related Infections - etiology</topic><topic>Prosthesis-Related Infections - pathology</topic><topic>Radiopharmaceuticals</topic><topic>Reproducibility of Results</topic><topic>Sensitivity and Specificity</topic><topic>Technetium Tc 99m Medronate</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pakos, E E</creatorcontrib><creatorcontrib>Fotopoulos, A D</creatorcontrib><creatorcontrib>Stafilas, K S</creatorcontrib><creatorcontrib>Gavriilidis, I</creatorcontrib><creatorcontrib>Al Boukarali, G</creatorcontrib><creatorcontrib>Tsiouris, S</creatorcontrib><creatorcontrib>Xenakis, T A</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of international medical research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pakos, E E</au><au>Fotopoulos, A D</au><au>Stafilas, K S</au><au>Gavriilidis, I</au><au>Al Boukarali, G</au><au>Tsiouris, S</au><au>Xenakis, T A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Use of (99m)Tc-sulesomab for the diagnosis of prosthesis infection after total joint arthroplasty</atitle><jtitle>Journal of international medical research</jtitle><addtitle>J Int Med Res</addtitle><date>2007-07</date><risdate>2007</risdate><volume>35</volume><issue>4</issue><spage>474</spage><epage>481</epage><pages>474-481</pages><issn>0300-0605</issn><abstract>This study aimed to evaluate the diagnostic efficacy of antigranulocyte scintigraphy using the antibody fragment (99m)Tc-sulesomab (LeukoScan) for the diagnosis of prosthesis infection in patients with total hip or knee arthroplasty. The results from 19 patients with suspected total joint arthroplasty infection who had undergone a three-phase bone scan and a subsequent examination with (99m)Tc-sulesomab during a 1-year period were reviewed. Twelve patients were shown to have prosthesis infection on culture of aspirated synovial fluid or intra-operative samples. The overall sensitivity, specificity, positive and negative predictive values, and diagnostic accuracy for (99m)Tc-sulesomab were 75%, 86%, 90%, 66% and 79%, respectively, compared with 54%, 83%, 88%, 45% and 63%, respectively, for the three-phase bone scan. This study showed that (99m)Tc-sulesomab had good diagnostic value for the detection of prosthesis infection. The combination of (99m)Tc-sulesomab with other laboratory or imaging examinations may improve diagnostic performance in prosthesis infection and should be investigated further.</abstract><cop>England</cop><pmid>17697524</pmid><doi>10.1177/147323000703500406</doi><tpages>8</tpages></addata></record> |
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| subjects | Adult Antibodies, Monoclonal - immunology Antibodies, Monoclonal, Murine-Derived Arthroplasty, Replacement Female Hip Joint - diagnostic imaging Hip Prosthesis - adverse effects Hospitals, Teaching Humans Knee Joint - diagnostic imaging Knee Prosthesis - adverse effects Positron-Emission Tomography Prosthesis-Related Infections - diagnostic imaging Prosthesis-Related Infections - etiology Prosthesis-Related Infections - pathology Radiopharmaceuticals Reproducibility of Results Sensitivity and Specificity Technetium Tc 99m Medronate |
| title | Use of (99m)Tc-sulesomab for the diagnosis of prosthesis infection after total joint arthroplasty |
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