Knockout of α-calcitonin gene-related peptide reduces cholangiocyte proliferation in bile duct ligated mice

The role of sensory innervation in the regulation of liver physiology and the pathogenesis of cholestatic liver disease are undefined. Biliary proliferation has been shown to be coordinately controlled by parasympathetic and sympathetic innervation of the liver. The aim of our study was to address t...

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Veröffentlicht in:	Laboratory investigation 2007-09, Vol.87 (9), p.914-926
Hauptverfasser:	Glaser, Shannon S, Ueno, Yoshiyuki, DeMorrow, Sharon, Chiasson, Valorie L, Katki, Khurshed A, Venter, Julie, Francis, Heather L, Dickerson, Ian M, DiPette, Donald J, Supowit, Scott C, Alpini, Gianfranco D
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bile Ducts, Intrahepatic - metabolism Bile Ducts, Intrahepatic - pathology Bile Ducts, Intrahepatic - physiopathology Biliary Tract - cytology Calcitonin Gene-Related Peptide - blood Calcitonin Gene-Related Peptide - metabolism cAMP Cell Proliferation Cholangitis - metabolism Cholangitis - physiopathology cholestasis Cholestasis, Extrahepatic - physiopathology Disease Models, Animal Epithelial Cells - metabolism Epithelial Cells - pathology intrahepatic biliary epithelium Laboratory Medicine Male Medicine Medicine & Public Health Mice Mice, Knockout Pathology protein kinase A research-article sensory innervation
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