Spy1 Enhances Phosphorylation and Degradation of the Cell Cycle Inhibitor p27

The cyclin dependent kinase inhibitor (CKI) p27Kip1 binds to cyclin E/CDK2 complexes and prevents premature S-phase entry. During late G 1 and throughout S phase, p27 phosphorylation at T187 leads to its subsequent degradation, which relieves CDK2 inhibition to promote cell cycle progression. Howeve...

Ausführliche Beschreibung