Identification of Alpha-1 Acid Glycoprotein as a Lysophospholipid Binding Protein:  A Complementary Role to Albumin in the Scavenging of Lysophosphatidylcholine

Alpha-1 acid glycoprotein (AGP, orosomucoid), a major acute phase protein in plasma, displays potent cytoprotective and anti-inflammatory activities whose molecular mechanisms are largely unknown. Because AGP binds various exogenous drugs, we have searched for endogenous ligands for AGP. We found th...

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Veröffentlicht in:	Biochemistry (Easton) 2006-11, Vol.45 (47), p.14021-14031
Hauptverfasser:	Ojala, Pauli J, Hermansson, Martin, Tolvanen, Martti, Polvinen, Kirsi, Hirvonen, Tia, Impola, Ulla, Jauhiainen, Matti, Somerharju, Pentti, Parkkinen, Jaakko
Format:	Artikel
Sprache:	eng
Schlagworte:	Fluorescent Dyes Lysophospholipids - metabolism Mass Spectrometry Models, Molecular Orosomucoid - chemistry Orosomucoid - metabolism Phosphorylcholine - metabolism Protein Binding
Online-Zugang:	Volltext
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