Paradoxical constitutive behavioral sensitization to amphetamine in mice lacking 5-HT2A receptors

Although locomotor response to d-amphetamine is considered as mediated by an increased release of dopamine in the ventral striatum, blockade of either alpha1b-adrenergic or 5-HT2A receptors almost completely inhibits d-amphetamine-induced locomotor response in mice. In agreement with this finding, m...

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Veröffentlicht in:	Psychopharmacologia 2007-09, Vol.194 (1), p.11-20
Hauptverfasser:	SALOMON, Lucas, LANTERI, Christophe, GODEHEU, Gérard, BLANC, Gérard, GINGRICH, Jay, TASSIN, Jean-Pol
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenergic alpha-1 Receptor Antagonists Amphetamines Animals Behavior, Animal - drug effects Behavior, Animal - physiology Biological and medical sciences Central Nervous System Stimulants - pharmacology Dextroamphetamine - pharmacology Dose-Response Relationship, Drug Fluorobenzenes - pharmacology Genetics Histamine H2 Antagonists - pharmacology Medical sciences Mice Mice, Knockout Motor Activity - drug effects Motor Activity - physiology Mutation Neuropharmacology Neurotransmitters Pharmacology Pharmacology. Drug treatments Phenols - pharmacology Prazosin - pharmacology Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology Psychology. Psychoanalysis. Psychiatry Psychopharmacology Receptor, Serotonin, 5-HT2A - deficiency Receptor, Serotonin, 5-HT2A - genetics Receptor, Serotonin, 5-HT2A - physiology Rodents
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