Angiotensin II induces NF-κB activation in HUVEC via the p38MAPK pathway

Angiotensin II (Ang II) is the main active peptide of the renin–angiotensin system (RAS), producing a number of inflammatory mediators that lead to endothelial dysfunction and the progression of atherosclerosis. Ang II-induced NF-κB nuclear translocation plays a pivotal role in this response. This s...

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Veröffentlicht in:	Peptides (New York, N.Y. : 1980) N.Y. : 1980), 2006-12, Vol.27 (12), p.3269-3275
Hauptverfasser:	Guo, Rui-Wei, Yang, Li-Xia, Li, Mao-Quan, Liu, Bei, Wang, Xian-Mei
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiotensin II Angiotensin II - physiology Biological and medical sciences Cells, Cultured DNA - metabolism Endothelium, Vascular - cytology Endothelium, Vascular - metabolism Fundamental and applied biological sciences. Psychology Human umbilical vein endothelial cell Humans MAP Kinase Signaling System - physiology MAPK NF-kappa B - metabolism NF-κB p38 Mitogen-Activated Protein Kinases - physiology Protein Binding Receptor, Angiotensin, Type 1 - physiology Vertebrates: endocrinology
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