Is ineffective oesophageal motility associated with reflux oesophagitis?
OBJECTIVETo evaluate the association between ineffective oesophageal motility and reflux oesophagitis controlling for hiatal hernia, hypotensive lower oesophageal sphincter and male sex in patients with gastro-oesophageal reflux disease. METHODSA total of 387 patients with reflux disease (mean age,...
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| Veröffentlicht in: | European journal of gastroenterology & hepatology 2007-09, Vol.19 (9), p.783-787 |
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| container_title | European journal of gastroenterology & hepatology |
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| creator | Fornari, Fernando Callegari-Jacques, Sidia M Scussel, Plácido J Madalosso, Luiz F Barros, Enrique F Barros, Sérgio G.S |
| description | OBJECTIVETo evaluate the association between ineffective oesophageal motility and reflux oesophagitis controlling for hiatal hernia, hypotensive lower oesophageal sphincter and male sex in patients with gastro-oesophageal reflux disease.
METHODSA total of 387 patients with reflux disease (mean age, 46 years, 42% men) were consecutively selected from a database. All patients underwent upper endoscopy, oesophageal manometry and 24 h oesophageal pH-metry in accordance with a standardized protocol. Reflux disease was confirmed either by endoscopy (oesophagitis grade I–IV according to Savary–Miller) or by pH-metry (increased acid exposure). Hiatal hernia was diagnosed endoscopically, whereas ineffective oesophageal motility and hypotensive lower oesophageal sphincter were characterized during manometry testing. The association between ineffective oesophageal motility and reflux oesophagitis was assessed by logistic regression analysis.
RESULTSA total of 166 patients with oesophagitis (mean age 45 years, 49% men) and 221 without oesophagitis (mean age 46 years, 37% men) were present. Prevalences of ineffective oesophageal motility, hiatal hernia, hypotensive lower oesophageal sphincter and male sex were significantly higher in patients with oesophagitis compared with those without oesophagitis (P |
| doi_str_mv | 10.1097/MEG.0b013e3282748ecf |
| format | Article |
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METHODSA total of 387 patients with reflux disease (mean age, 46 years, 42% men) were consecutively selected from a database. All patients underwent upper endoscopy, oesophageal manometry and 24 h oesophageal pH-metry in accordance with a standardized protocol. Reflux disease was confirmed either by endoscopy (oesophagitis grade I–IV according to Savary–Miller) or by pH-metry (increased acid exposure). Hiatal hernia was diagnosed endoscopically, whereas ineffective oesophageal motility and hypotensive lower oesophageal sphincter were characterized during manometry testing. The association between ineffective oesophageal motility and reflux oesophagitis was assessed by logistic regression analysis.
RESULTSA total of 166 patients with oesophagitis (mean age 45 years, 49% men) and 221 without oesophagitis (mean age 46 years, 37% men) were present. Prevalences of ineffective oesophageal motility, hiatal hernia, hypotensive lower oesophageal sphincter and male sex were significantly higher in patients with oesophagitis compared with those without oesophagitis (P<0.05). Ineffective oesophageal motility was independently associated with oesophagitis after multivariate logistic regression analysis (odds ratio=1.68; 95% confidence interval=1.04–2.70).
CONCLUSIONIneffective oesophageal motility is associated with reflux oesophagitis, independently of hiatal hernia, hypotensive lower oesophageal sphincter and male sex.</description><identifier>ISSN: 0954-691X</identifier><identifier>EISSN: 1473-5687</identifier><identifier>DOI: 10.1097/MEG.0b013e3282748ecf</identifier><identifier>PMID: 17700264</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins, Inc</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Digestive system. Abdomen ; Endoscopy ; Esophageal Motility Disorders - complications ; Esophageal Motility Disorders - diagnosis ; Esophageal pH Monitoring ; Esophagitis, Peptic - etiology ; Esophagoscopy ; Esophagus ; Female ; Gastroenterology. Liver. Pancreas. Abdomen ; Gastroesophageal Reflux - complications ; Hernia, Hiatal - complications ; Humans ; Investigative techniques, diagnostic techniques (general aspects) ; Male ; Manometry - methods ; Medical sciences ; Middle Aged ; Monitoring, Ambulatory - methods ; Other diseases. Semiology ; Sex Factors</subject><ispartof>European journal of gastroenterology & hepatology, 2007-09, Vol.19 (9), p.783-787</ispartof><rights>2007 Lippincott Williams & Wilkins, Inc.</rights><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3808-cd3eacc03324d5926e5b9e1d2e4d69875ce30928ef57ead3f4a1e7ce3d1ff5473</citedby><cites>FETCH-LOGICAL-c3808-cd3eacc03324d5926e5b9e1d2e4d69875ce30928ef57ead3f4a1e7ce3d1ff5473</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18969804$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17700264$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fornari, Fernando</creatorcontrib><creatorcontrib>Callegari-Jacques, Sidia M</creatorcontrib><creatorcontrib>Scussel, Plácido J</creatorcontrib><creatorcontrib>Madalosso, Luiz F</creatorcontrib><creatorcontrib>Barros, Enrique F</creatorcontrib><creatorcontrib>Barros, Sérgio G.S</creatorcontrib><title>Is ineffective oesophageal motility associated with reflux oesophagitis?</title><title>European journal of gastroenterology & hepatology</title><addtitle>Eur J Gastroenterol Hepatol</addtitle><description>OBJECTIVETo evaluate the association between ineffective oesophageal motility and reflux oesophagitis controlling for hiatal hernia, hypotensive lower oesophageal sphincter and male sex in patients with gastro-oesophageal reflux disease.
METHODSA total of 387 patients with reflux disease (mean age, 46 years, 42% men) were consecutively selected from a database. All patients underwent upper endoscopy, oesophageal manometry and 24 h oesophageal pH-metry in accordance with a standardized protocol. Reflux disease was confirmed either by endoscopy (oesophagitis grade I–IV according to Savary–Miller) or by pH-metry (increased acid exposure). Hiatal hernia was diagnosed endoscopically, whereas ineffective oesophageal motility and hypotensive lower oesophageal sphincter were characterized during manometry testing. The association between ineffective oesophageal motility and reflux oesophagitis was assessed by logistic regression analysis.
RESULTSA total of 166 patients with oesophagitis (mean age 45 years, 49% men) and 221 without oesophagitis (mean age 46 years, 37% men) were present. Prevalences of ineffective oesophageal motility, hiatal hernia, hypotensive lower oesophageal sphincter and male sex were significantly higher in patients with oesophagitis compared with those without oesophagitis (P<0.05). Ineffective oesophageal motility was independently associated with oesophagitis after multivariate logistic regression analysis (odds ratio=1.68; 95% confidence interval=1.04–2.70).
CONCLUSIONIneffective oesophageal motility is associated with reflux oesophagitis, independently of hiatal hernia, hypotensive lower oesophageal sphincter and male sex.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Digestive system. Abdomen</subject><subject>Endoscopy</subject><subject>Esophageal Motility Disorders - complications</subject><subject>Esophageal Motility Disorders - diagnosis</subject><subject>Esophageal pH Monitoring</subject><subject>Esophagitis, Peptic - etiology</subject><subject>Esophagoscopy</subject><subject>Esophagus</subject><subject>Female</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Gastroesophageal Reflux - complications</subject><subject>Hernia, Hiatal - complications</subject><subject>Humans</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Male</subject><subject>Manometry - methods</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Monitoring, Ambulatory - methods</subject><subject>Other diseases. Semiology</subject><subject>Sex Factors</subject><issn>0954-691X</issn><issn>1473-5687</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkEtPGzEURq2KqoTHP6iq2dDd0OvHjO1VVUU0IFGxoVJ3luO5bgxOJh17SPn3GBgRiYVl2Tr38R1CPlM4p6Dlt18Xi3NYAuXImWJSKHT-A5lRIXndtEoekBnoRtStpn8OyVFKdwBUcio_kUMqJQBrxYxcXqUqbNB7dDk8YNVj6rcr-xdtrNZ9DjHkx8qm1LtgM3bVLuRVNaCP4_83NuSQvp-Qj97GhKfTfUx-_7y4nV_W1zeLq_mP69pxBap2HUfrHHDORNdo1mKz1Eg7hqJrtZKNQw6aKfSNRNtxLyxFWT476n1Tsh2Tr699t0P_b8SUzTokhzHaDfZjMq2ireQvoHgF3dCnVFY22yGs7fBoKJhng6YYNO8NlrIvU_9xucZuXzQpK8DZBNjkbPSD3biQ9pzSJQeI_fxdHzMO6T6OOxzMqpjNKwMAgkkuawYgQZdnXQ4o_gSEFYus</recordid><startdate>200709</startdate><enddate>200709</enddate><creator>Fornari, Fernando</creator><creator>Callegari-Jacques, Sidia M</creator><creator>Scussel, Plácido J</creator><creator>Madalosso, Luiz F</creator><creator>Barros, Enrique F</creator><creator>Barros, Sérgio G.S</creator><general>Lippincott Williams & Wilkins, Inc</general><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200709</creationdate><title>Is ineffective oesophageal motility associated with reflux oesophagitis?</title><author>Fornari, Fernando ; Callegari-Jacques, Sidia M ; Scussel, Plácido J ; Madalosso, Luiz F ; Barros, Enrique F ; Barros, Sérgio G.S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3808-cd3eacc03324d5926e5b9e1d2e4d69875ce30928ef57ead3f4a1e7ce3d1ff5473</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Digestive system. Abdomen</topic><topic>Endoscopy</topic><topic>Esophageal Motility Disorders - complications</topic><topic>Esophageal Motility Disorders - diagnosis</topic><topic>Esophageal pH Monitoring</topic><topic>Esophagitis, Peptic - etiology</topic><topic>Esophagoscopy</topic><topic>Esophagus</topic><topic>Female</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Gastroesophageal Reflux - complications</topic><topic>Hernia, Hiatal - complications</topic><topic>Humans</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Male</topic><topic>Manometry - methods</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Monitoring, Ambulatory - methods</topic><topic>Other diseases. Semiology</topic><topic>Sex Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fornari, Fernando</creatorcontrib><creatorcontrib>Callegari-Jacques, Sidia M</creatorcontrib><creatorcontrib>Scussel, Plácido J</creatorcontrib><creatorcontrib>Madalosso, Luiz F</creatorcontrib><creatorcontrib>Barros, Enrique F</creatorcontrib><creatorcontrib>Barros, Sérgio G.S</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of gastroenterology & hepatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fornari, Fernando</au><au>Callegari-Jacques, Sidia M</au><au>Scussel, Plácido J</au><au>Madalosso, Luiz F</au><au>Barros, Enrique F</au><au>Barros, Sérgio G.S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Is ineffective oesophageal motility associated with reflux oesophagitis?</atitle><jtitle>European journal of gastroenterology & hepatology</jtitle><addtitle>Eur J Gastroenterol Hepatol</addtitle><date>2007-09</date><risdate>2007</risdate><volume>19</volume><issue>9</issue><spage>783</spage><epage>787</epage><pages>783-787</pages><issn>0954-691X</issn><eissn>1473-5687</eissn><abstract>OBJECTIVETo evaluate the association between ineffective oesophageal motility and reflux oesophagitis controlling for hiatal hernia, hypotensive lower oesophageal sphincter and male sex in patients with gastro-oesophageal reflux disease.
METHODSA total of 387 patients with reflux disease (mean age, 46 years, 42% men) were consecutively selected from a database. All patients underwent upper endoscopy, oesophageal manometry and 24 h oesophageal pH-metry in accordance with a standardized protocol. Reflux disease was confirmed either by endoscopy (oesophagitis grade I–IV according to Savary–Miller) or by pH-metry (increased acid exposure). Hiatal hernia was diagnosed endoscopically, whereas ineffective oesophageal motility and hypotensive lower oesophageal sphincter were characterized during manometry testing. The association between ineffective oesophageal motility and reflux oesophagitis was assessed by logistic regression analysis.
RESULTSA total of 166 patients with oesophagitis (mean age 45 years, 49% men) and 221 without oesophagitis (mean age 46 years, 37% men) were present. Prevalences of ineffective oesophageal motility, hiatal hernia, hypotensive lower oesophageal sphincter and male sex were significantly higher in patients with oesophagitis compared with those without oesophagitis (P<0.05). Ineffective oesophageal motility was independently associated with oesophagitis after multivariate logistic regression analysis (odds ratio=1.68; 95% confidence interval=1.04–2.70).
CONCLUSIONIneffective oesophageal motility is associated with reflux oesophagitis, independently of hiatal hernia, hypotensive lower oesophageal sphincter and male sex.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins, Inc</pub><pmid>17700264</pmid><doi>10.1097/MEG.0b013e3282748ecf</doi><tpages>5</tpages></addata></record> |
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| ispartof | European journal of gastroenterology & hepatology, 2007-09, Vol.19 (9), p.783-787 |
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| subjects | Adolescent Adult Aged Aged, 80 and over Biological and medical sciences Digestive system. Abdomen Endoscopy Esophageal Motility Disorders - complications Esophageal Motility Disorders - diagnosis Esophageal pH Monitoring Esophagitis, Peptic - etiology Esophagoscopy Esophagus Female Gastroenterology. Liver. Pancreas. Abdomen Gastroesophageal Reflux - complications Hernia, Hiatal - complications Humans Investigative techniques, diagnostic techniques (general aspects) Male Manometry - methods Medical sciences Middle Aged Monitoring, Ambulatory - methods Other diseases. Semiology Sex Factors |
| title | Is ineffective oesophageal motility associated with reflux oesophagitis? |
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