Progress in the Development of the DexAide Right Ventricular Assist Device
The DexAide right ventricular assist device (RVAD) is an implantable centrifugal pump modified from the CorAide left ventricular assist device. As previously published, in vitro performance testing of the DexAide RVAD has met design criteria, and the nominal operating condition of 4 l/min and 20 mm...
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| Veröffentlicht in: | ASAIO journal (1992) 2006-11, Vol.52 (6), p.630-633 |
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| container_title | ASAIO journal (1992) |
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| creator | Fukamachi, Kiyotaka Ootaki, Yoshio Horvath, David J Massiello, Alex L Kamohara, Keiji Akiyama, Masatoshi Cingoz, Faruk Ootaki, Chiyo Kopcak, Michael W Dessoffy, Raymond Liu, Jenny Chen, Ji-Feng Zhou, Qun Benefit, Stephen Golding, Leonard A.R Alfini, Sue Rowe, David T |
| description | The DexAide right ventricular assist device (RVAD) is an implantable centrifugal pump modified from the CorAide left ventricular assist device. As previously published, in vitro performance testing of the DexAide RVAD has met design criteria, and the nominal operating condition of 4 l/min and 20 mm Hg pressure rise was achieved at 2,000 rpm, with a power consumption of 1.9 watts. In vivo studies in 14 calves have demonstrated acceptable hemodynamic characteristics. The calf inflow cannula design is still evolving to minimize depositions on the cannula observed in most experiments. Fitting studies were performed in 5 cadavers and 2 patients to reconfigure the cannulae for use in humans. The design and development of external electronics have been completed for the stand-alone RVAD system, and verification tests are under way in preparation for preclinical tests. Work on the external electronics design for the biventricular assist system is ongoing.In conclusion, the initial in vitro and in vivo studies have demonstrated acceptable hemodynamic characteristics of the DexAide RVAD. The design and development of the external electronic components for the stand-alone RVAD system have been completed. The calf inflow cannula is being redesigned, and chronic in vivo tests are under way. |
| doi_str_mv | 10.1097/01.mat.0000240700.03478.d0 |
| format | Article |
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As previously published, in vitro performance testing of the DexAide RVAD has met design criteria, and the nominal operating condition of 4 l/min and 20 mm Hg pressure rise was achieved at 2,000 rpm, with a power consumption of 1.9 watts. In vivo studies in 14 calves have demonstrated acceptable hemodynamic characteristics. The calf inflow cannula design is still evolving to minimize depositions on the cannula observed in most experiments. Fitting studies were performed in 5 cadavers and 2 patients to reconfigure the cannulae for use in humans. The design and development of external electronics have been completed for the stand-alone RVAD system, and verification tests are under way in preparation for preclinical tests. Work on the external electronics design for the biventricular assist system is ongoing.In conclusion, the initial in vitro and in vivo studies have demonstrated acceptable hemodynamic characteristics of the DexAide RVAD. The design and development of the external electronic components for the stand-alone RVAD system have been completed. 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As previously published, in vitro performance testing of the DexAide RVAD has met design criteria, and the nominal operating condition of 4 l/min and 20 mm Hg pressure rise was achieved at 2,000 rpm, with a power consumption of 1.9 watts. In vivo studies in 14 calves have demonstrated acceptable hemodynamic characteristics. The calf inflow cannula design is still evolving to minimize depositions on the cannula observed in most experiments. Fitting studies were performed in 5 cadavers and 2 patients to reconfigure the cannulae for use in humans. The design and development of external electronics have been completed for the stand-alone RVAD system, and verification tests are under way in preparation for preclinical tests. Work on the external electronics design for the biventricular assist system is ongoing.In conclusion, the initial in vitro and in vivo studies have demonstrated acceptable hemodynamic characteristics of the DexAide RVAD. The design and development of the external electronic components for the stand-alone RVAD system have been completed. The calf inflow cannula is being redesigned, and chronic in vivo tests are under way.</description><subject>Animals</subject><subject>Biomedical Engineering</subject><subject>Blood Pressure</subject><subject>Cattle</subject><subject>Heart Failure - surgery</subject><subject>Heart-Assist Devices - trends</subject><subject>Humans</subject><subject>Prosthesis Design</subject><subject>Pulsatile Flow</subject><issn>1058-2916</issn><issn>1538-943X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkFtP3DAQhS1Exa38BRT1gbeEmdhrx31bcUdIrRBFvFleZ8ymTTaLnRT67-tlI-EXe2bOOWN9jH1DKBC0OgMsOjsUkE4pQAEUwIWqihp22AHOeJVrwZ930xtmVV5qlPvsMMbfAGnIcY_to0JUMMMDdvcz9C-BYsyaVTYsKbugv9T2645WQ9b7qfU-b2rKHpqX5ZA9pUlo3NjakM1jbOKw8TSOvrIv3raRjqf7iP26unw8v8nvf1zfns_vcydQiFyV2mrvoEwfcNIi185L7mZkbe29q7nwEohjKXWpBEnh9aLGZABFbqErfsROt7nr0L-OFAfTNdFR29oV9WM0skKpQJRJ-H0rdKGPMZA369B0NvwzCGZD0gCaRNJ8kjQfJE0NyXwybRkXHdWf1gldEoit4K1vBwrxTzu-UTBLsu2wnCIryEsAiZiqfNMS_D9_xn-_</recordid><startdate>200611</startdate><enddate>200611</enddate><creator>Fukamachi, Kiyotaka</creator><creator>Ootaki, Yoshio</creator><creator>Horvath, David J</creator><creator>Massiello, Alex L</creator><creator>Kamohara, Keiji</creator><creator>Akiyama, Masatoshi</creator><creator>Cingoz, Faruk</creator><creator>Ootaki, Chiyo</creator><creator>Kopcak, Michael W</creator><creator>Dessoffy, Raymond</creator><creator>Liu, Jenny</creator><creator>Chen, Ji-Feng</creator><creator>Zhou, Qun</creator><creator>Benefit, Stephen</creator><creator>Golding, Leonard A.R</creator><creator>Alfini, Sue</creator><creator>Rowe, David T</creator><general>Copyright by the American Society for Artificial Internal Organs</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200611</creationdate><title>Progress in the Development of the DexAide Right Ventricular Assist Device</title><author>Fukamachi, Kiyotaka ; Ootaki, Yoshio ; Horvath, David J ; Massiello, Alex L ; Kamohara, Keiji ; Akiyama, Masatoshi ; Cingoz, Faruk ; Ootaki, Chiyo ; Kopcak, Michael W ; Dessoffy, Raymond ; Liu, Jenny ; Chen, Ji-Feng ; Zhou, Qun ; Benefit, Stephen ; Golding, Leonard A.R ; Alfini, Sue ; Rowe, David T</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4144-729a9fc02705c6a139cf63c5eaadffcd34f60e31269274e64f9bd1fc007ecb983</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Animals</topic><topic>Biomedical Engineering</topic><topic>Blood Pressure</topic><topic>Cattle</topic><topic>Heart Failure - surgery</topic><topic>Heart-Assist Devices - trends</topic><topic>Humans</topic><topic>Prosthesis Design</topic><topic>Pulsatile Flow</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fukamachi, Kiyotaka</creatorcontrib><creatorcontrib>Ootaki, Yoshio</creatorcontrib><creatorcontrib>Horvath, David J</creatorcontrib><creatorcontrib>Massiello, Alex L</creatorcontrib><creatorcontrib>Kamohara, Keiji</creatorcontrib><creatorcontrib>Akiyama, Masatoshi</creatorcontrib><creatorcontrib>Cingoz, Faruk</creatorcontrib><creatorcontrib>Ootaki, Chiyo</creatorcontrib><creatorcontrib>Kopcak, Michael W</creatorcontrib><creatorcontrib>Dessoffy, Raymond</creatorcontrib><creatorcontrib>Liu, Jenny</creatorcontrib><creatorcontrib>Chen, Ji-Feng</creatorcontrib><creatorcontrib>Zhou, Qun</creatorcontrib><creatorcontrib>Benefit, Stephen</creatorcontrib><creatorcontrib>Golding, Leonard A.R</creatorcontrib><creatorcontrib>Alfini, Sue</creatorcontrib><creatorcontrib>Rowe, David T</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>ASAIO journal (1992)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fukamachi, Kiyotaka</au><au>Ootaki, Yoshio</au><au>Horvath, David J</au><au>Massiello, Alex L</au><au>Kamohara, Keiji</au><au>Akiyama, Masatoshi</au><au>Cingoz, Faruk</au><au>Ootaki, Chiyo</au><au>Kopcak, Michael W</au><au>Dessoffy, Raymond</au><au>Liu, Jenny</au><au>Chen, Ji-Feng</au><au>Zhou, Qun</au><au>Benefit, Stephen</au><au>Golding, Leonard A.R</au><au>Alfini, Sue</au><au>Rowe, David T</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Progress in the Development of the DexAide Right Ventricular Assist Device</atitle><jtitle>ASAIO journal (1992)</jtitle><addtitle>ASAIO J</addtitle><date>2006-11</date><risdate>2006</risdate><volume>52</volume><issue>6</issue><spage>630</spage><epage>633</epage><pages>630-633</pages><issn>1058-2916</issn><eissn>1538-943X</eissn><abstract>The DexAide right ventricular assist device (RVAD) is an implantable centrifugal pump modified from the CorAide left ventricular assist device. As previously published, in vitro performance testing of the DexAide RVAD has met design criteria, and the nominal operating condition of 4 l/min and 20 mm Hg pressure rise was achieved at 2,000 rpm, with a power consumption of 1.9 watts. In vivo studies in 14 calves have demonstrated acceptable hemodynamic characteristics. The calf inflow cannula design is still evolving to minimize depositions on the cannula observed in most experiments. Fitting studies were performed in 5 cadavers and 2 patients to reconfigure the cannulae for use in humans. The design and development of external electronics have been completed for the stand-alone RVAD system, and verification tests are under way in preparation for preclinical tests. Work on the external electronics design for the biventricular assist system is ongoing.In conclusion, the initial in vitro and in vivo studies have demonstrated acceptable hemodynamic characteristics of the DexAide RVAD. The design and development of the external electronic components for the stand-alone RVAD system have been completed. The calf inflow cannula is being redesigned, and chronic in vivo tests are under way.</abstract><cop>United States</cop><pub>Copyright by the American Society for Artificial Internal Organs</pub><pmid>17117051</pmid><doi>10.1097/01.mat.0000240700.03478.d0</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | ASAIO journal (1992), 2006-11, Vol.52 (6), p.630-633 |
| issn | 1058-2916 1538-943X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_68167042 |
| source | MEDLINE; Journals@Ovid LWW Legacy Archive; Journals@Ovid Complete; EZB-FREE-00999 freely available EZB journals |
| subjects | Animals Biomedical Engineering Blood Pressure Cattle Heart Failure - surgery Heart-Assist Devices - trends Humans Prosthesis Design Pulsatile Flow |
| title | Progress in the Development of the DexAide Right Ventricular Assist Device |
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