Morbidity associated with repeated transrectal high-intensity focused ultrasound treatment of localized prostate cancer
The aim of this cross-sectional study was to compare single with repeated high-intensity focused ultrasound (HIFU) treatment in patients with localized prostate cancer, regarding treatment-related morbidity. A number of 223 consecutive patients with localized prostate cancer were treated with HIFU....
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| Veröffentlicht in: | World journal of urology 2006-11, Vol.24 (5), p.585-590 |
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| creator | BLANA, Andreas ROGENHOFER, Sebastian GANZER, Roman WILD, Peter J WIELAND, Wolf F WALTER, Bernhard |
| description | The aim of this cross-sectional study was to compare single with repeated high-intensity focused ultrasound (HIFU) treatment in patients with localized prostate cancer, regarding treatment-related morbidity. A number of 223 consecutive patients with localized prostate cancer were treated with HIFU. Among them, 174 (78%) patients had one treatment, while 49 (22%) needed a second treatment. The patients' status and treatment-related side effects were followed up. The complications rates after one HIFU in 223 patients were: urinary tract infection 0.4%, chronic pelvic pain 0.9%, infravesical obstruction 19.7%, stressincontinence 7.6%, impotence 49.8%. Among the 49 patients who received a second HIFU therapy, the cumulative incontinence rate (12.2%; P = 0.024) and cumulative impotence rate (55%; P < 0.001) were significantly increased. Although there is an increase in morbidity if transrectal HIFU is repeated, the risk of side effects related to additional HIFU sessions in the case of primary treatment failure is still low. |
| doi_str_mv | 10.1007/s00345-006-0107-x |
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A number of 223 consecutive patients with localized prostate cancer were treated with HIFU. Among them, 174 (78%) patients had one treatment, while 49 (22%) needed a second treatment. The patients' status and treatment-related side effects were followed up. The complications rates after one HIFU in 223 patients were: urinary tract infection 0.4%, chronic pelvic pain 0.9%, infravesical obstruction 19.7%, stressincontinence 7.6%, impotence 49.8%. Among the 49 patients who received a second HIFU therapy, the cumulative incontinence rate (12.2%; P = 0.024) and cumulative impotence rate (55%; P < 0.001) were significantly increased. Although there is an increase in morbidity if transrectal HIFU is repeated, the risk of side effects related to additional HIFU sessions in the case of primary treatment failure is still low.</description><identifier>ISSN: 0724-4983</identifier><identifier>EISSN: 1433-8726</identifier><identifier>DOI: 10.1007/s00345-006-0107-x</identifier><identifier>PMID: 16850340</identifier><identifier>CODEN: WJURDJ</identifier><language>eng</language><publisher>Heidelberg: Springer</publisher><subject>Aged ; Biological and medical sciences ; Cross-Sectional Studies ; Epidemiology ; Erectile Dysfunction - epidemiology ; Erectile Dysfunction - etiology ; General aspects ; Humans ; Incidence ; Male ; Medical sciences ; Middle Aged ; Morbidity ; Nephrology. Urinary tract diseases ; Prostatic Neoplasms - therapy ; Public health. Hygiene ; Public health. Hygiene-occupational medicine ; Treatment Outcome ; Tumors of the urinary system ; Ultrasound, High-Intensity Focused, Transrectal - adverse effects ; Ultrasound, High-Intensity Focused, Transrectal - methods ; Urinary Incontinence, Stress - epidemiology ; Urinary Incontinence, Stress - etiology ; Urinary tract. 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A number of 223 consecutive patients with localized prostate cancer were treated with HIFU. Among them, 174 (78%) patients had one treatment, while 49 (22%) needed a second treatment. The patients' status and treatment-related side effects were followed up. The complications rates after one HIFU in 223 patients were: urinary tract infection 0.4%, chronic pelvic pain 0.9%, infravesical obstruction 19.7%, stressincontinence 7.6%, impotence 49.8%. Among the 49 patients who received a second HIFU therapy, the cumulative incontinence rate (12.2%; P = 0.024) and cumulative impotence rate (55%; P < 0.001) were significantly increased. Although there is an increase in morbidity if transrectal HIFU is repeated, the risk of side effects related to additional HIFU sessions in the case of primary treatment failure is still low.</description><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Cross-Sectional Studies</subject><subject>Epidemiology</subject><subject>Erectile Dysfunction - epidemiology</subject><subject>Erectile Dysfunction - etiology</subject><subject>General aspects</subject><subject>Humans</subject><subject>Incidence</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Morbidity</subject><subject>Nephrology. Urinary tract diseases</subject><subject>Prostatic Neoplasms - therapy</subject><subject>Public health. Hygiene</subject><subject>Public health. Hygiene-occupational medicine</subject><subject>Treatment Outcome</subject><subject>Tumors of the urinary system</subject><subject>Ultrasound, High-Intensity Focused, Transrectal - adverse effects</subject><subject>Ultrasound, High-Intensity Focused, Transrectal - methods</subject><subject>Urinary Incontinence, Stress - epidemiology</subject><subject>Urinary Incontinence, Stress - etiology</subject><subject>Urinary tract. 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Urinary tract diseases</topic><topic>Prostatic Neoplasms - therapy</topic><topic>Public health. Hygiene</topic><topic>Public health. Hygiene-occupational medicine</topic><topic>Treatment Outcome</topic><topic>Tumors of the urinary system</topic><topic>Ultrasound, High-Intensity Focused, Transrectal - adverse effects</topic><topic>Ultrasound, High-Intensity Focused, Transrectal - methods</topic><topic>Urinary Incontinence, Stress - epidemiology</topic><topic>Urinary Incontinence, Stress - etiology</topic><topic>Urinary tract. 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A number of 223 consecutive patients with localized prostate cancer were treated with HIFU. Among them, 174 (78%) patients had one treatment, while 49 (22%) needed a second treatment. The patients' status and treatment-related side effects were followed up. The complications rates after one HIFU in 223 patients were: urinary tract infection 0.4%, chronic pelvic pain 0.9%, infravesical obstruction 19.7%, stressincontinence 7.6%, impotence 49.8%. Among the 49 patients who received a second HIFU therapy, the cumulative incontinence rate (12.2%; P = 0.024) and cumulative impotence rate (55%; P < 0.001) were significantly increased. Although there is an increase in morbidity if transrectal HIFU is repeated, the risk of side effects related to additional HIFU sessions in the case of primary treatment failure is still low.</abstract><cop>Heidelberg</cop><cop>Berlin</cop><cop>New York, NY</cop><pub>Springer</pub><pmid>16850340</pmid><doi>10.1007/s00345-006-0107-x</doi><tpages>6</tpages></addata></record> |
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| subjects | Aged Biological and medical sciences Cross-Sectional Studies Epidemiology Erectile Dysfunction - epidemiology Erectile Dysfunction - etiology General aspects Humans Incidence Male Medical sciences Middle Aged Morbidity Nephrology. Urinary tract diseases Prostatic Neoplasms - therapy Public health. Hygiene Public health. Hygiene-occupational medicine Treatment Outcome Tumors of the urinary system Ultrasound, High-Intensity Focused, Transrectal - adverse effects Ultrasound, High-Intensity Focused, Transrectal - methods Urinary Incontinence, Stress - epidemiology Urinary Incontinence, Stress - etiology Urinary tract. Prostate gland |
| title | Morbidity associated with repeated transrectal high-intensity focused ultrasound treatment of localized prostate cancer |
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