In vitro study of the effectiveness of different dressings for debriding fibrin in blood clots from horses
Franz diffusion cells containing uniformly dehydrated equine blood clots to simulate fibrinous eschar were used to measure the rate of debridement of fibrin by novel and traditional wound dressings, under standardised conditions of temperature, pH and humidity. Significant increases in protein break...
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| Veröffentlicht in: | Veterinary record 2006-11, Vol.159 (21), p.712-717 |
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| creator | Pain, R. Sneddon, J. C. Cochrane, C. A. |
| description | Franz diffusion cells containing uniformly dehydrated equine blood clots to simulate fibrinous eschar were used to measure the rate of debridement of fibrin by novel and traditional wound dressings, under standardised conditions of temperature, pH and humidity. Significant increases in protein breakdown occurred within 24 hours with all the dressings, but not thereafter. In general, dressings hydrated in normal saline were better as debriding agents than dressings hydrated in water. Autolytic debriding agents were 47 per cent more effective than chemical debriding agents; specifically, hydrofibre and gauze dressings hydrated in saline broke down more than 3500 μg/ml of protein whereas dressings impregnated with proteolytic enzymatic agents digested less than 1400 μg/ml. |
| doi_str_mv | 10.1136/vr.159.21.712 |
| format | Article |
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C. ; Cochrane, C. A.</creator><creatorcontrib>Pain, R. ; Sneddon, J. C. ; Cochrane, C. A.</creatorcontrib><description>Franz diffusion cells containing uniformly dehydrated equine blood clots to simulate fibrinous eschar were used to measure the rate of debridement of fibrin by novel and traditional wound dressings, under standardised conditions of temperature, pH and humidity. Significant increases in protein breakdown occurred within 24 hours with all the dressings, but not thereafter. In general, dressings hydrated in normal saline were better as debriding agents than dressings hydrated in water. Autolytic debriding agents were 47 per cent more effective than chemical debriding agents; specifically, hydrofibre and gauze dressings hydrated in saline broke down more than 3500 μg/ml of protein whereas dressings impregnated with proteolytic enzymatic agents digested less than 1400 μg/ml.</description><identifier>ISSN: 0042-4900</identifier><identifier>EISSN: 2042-7670</identifier><identifier>DOI: 10.1136/vr.159.21.712</identifier><identifier>PMID: 17114382</identifier><language>eng</language><publisher>England: BMJ Publishing Group Limited</publisher><subject>Animals ; Bandages - veterinary ; Bandages, Hydrocolloid - veterinary ; Blood Coagulation - physiology ; Collagenases - therapeutic use ; debridement ; Debridement - methods ; Debridement - veterinary ; fibrin ; Fibrin - drug effects ; Horses ; Humidity ; Hydrogen-Ion Concentration ; Papain - therapeutic use ; Sodium Chloride - therapeutic use ; Streptokinase - therapeutic use ; Temperature ; Tissue Culture Techniques - veterinary ; tissue repair ; Treatment Outcome ; Urea - therapeutic use ; Wound Healing</subject><ispartof>Veterinary record, 2006-11, Vol.159 (21), p.712-717</ispartof><rights>British Veterinary Association. All rights reserved.</rights><rights>British Veterinary Association 2006</rights><rights>Copyright: 2006 British Veterinary Association. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b4234-632ec1622b3d60e8d3953fe8ea32c3a0a48362f32d3b418f03c7c0294f678f5b3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1136%2Fvr.159.21.712$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1136%2Fvr.159.21.712$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27923,27924,45573,45574</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17114382$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pain, R.</creatorcontrib><creatorcontrib>Sneddon, J. C.</creatorcontrib><creatorcontrib>Cochrane, C. A.</creatorcontrib><title>In vitro study of the effectiveness of different dressings for debriding fibrin in blood clots from horses</title><title>Veterinary record</title><addtitle>Vet Rec</addtitle><description>Franz diffusion cells containing uniformly dehydrated equine blood clots to simulate fibrinous eschar were used to measure the rate of debridement of fibrin by novel and traditional wound dressings, under standardised conditions of temperature, pH and humidity. Significant increases in protein breakdown occurred within 24 hours with all the dressings, but not thereafter. In general, dressings hydrated in normal saline were better as debriding agents than dressings hydrated in water. Autolytic debriding agents were 47 per cent more effective than chemical debriding agents; specifically, hydrofibre and gauze dressings hydrated in saline broke down more than 3500 μg/ml of protein whereas dressings impregnated with proteolytic enzymatic agents digested less than 1400 μg/ml.</description><subject>Animals</subject><subject>Bandages - veterinary</subject><subject>Bandages, Hydrocolloid - veterinary</subject><subject>Blood Coagulation - physiology</subject><subject>Collagenases - therapeutic use</subject><subject>debridement</subject><subject>Debridement - methods</subject><subject>Debridement - veterinary</subject><subject>fibrin</subject><subject>Fibrin - drug effects</subject><subject>Horses</subject><subject>Humidity</subject><subject>Hydrogen-Ion Concentration</subject><subject>Papain - therapeutic use</subject><subject>Sodium Chloride - therapeutic use</subject><subject>Streptokinase - therapeutic use</subject><subject>Temperature</subject><subject>Tissue Culture Techniques - veterinary</subject><subject>tissue repair</subject><subject>Treatment Outcome</subject><subject>Urea - therapeutic use</subject><subject>Wound Healing</subject><issn>0042-4900</issn><issn>2042-7670</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqFkdFrFDEQxoMo9lp99FUDQvFlz5lkN9l7rKXVQkHQ1tewu5m0OXY3Ndk9uf_eHHsg-KAQyMzHb4Yv-Rh7g7BGlOrjLq6x2qwFrjWKZ2wloBSFVhqesxUc6nIDcMJOU9oCiE0lxUt2ghqxlLVYse3NyHd-ioGnabZ7HhyfHomTc9RNfkcjpXQQrc9KpHHiNmbJjw-JuxC5pTZ6m1vufK5Gnk_bh2B514cpMzEM_DHEROkVe-GaPtHr433G7q-v7i6_FLdfP99cXtwWbSlkWSgpqEMlRCutAqqtzKYd1dRI0ckGmrKWSjgprGxLrB3ITnf5ZaVTunZVK8_Y-bL3KYafM6XJDD511PfNSGFORtWolIBNBt__BW7DHMfszaDWmwpAQ5WpYqG6GFKK5MxT9EMT9wbBHCIwu2hyBEagyRFk_u1x69wOZP_Qxz_PgFqAX76n_b-3mR9Xd98-XUONssyD75ZB1wTTPESfzP13ASgBUQhd60x8WIh22P7H5m9_1aez</recordid><startdate>20061118</startdate><enddate>20061118</enddate><creator>Pain, R.</creator><creator>Sneddon, J. C.</creator><creator>Cochrane, C. A.</creator><general>BMJ Publishing Group Limited</general><general>Blackwell Publishing Ltd</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20061118</creationdate><title>In vitro study of the effectiveness of different dressings for debriding fibrin in blood clots from horses</title><author>Pain, R. ; Sneddon, J. C. ; Cochrane, C. A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b4234-632ec1622b3d60e8d3953fe8ea32c3a0a48362f32d3b418f03c7c0294f678f5b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Animals</topic><topic>Bandages - veterinary</topic><topic>Bandages, Hydrocolloid - veterinary</topic><topic>Blood Coagulation - physiology</topic><topic>Collagenases - therapeutic use</topic><topic>debridement</topic><topic>Debridement - methods</topic><topic>Debridement - veterinary</topic><topic>fibrin</topic><topic>Fibrin - drug effects</topic><topic>Horses</topic><topic>Humidity</topic><topic>Hydrogen-Ion Concentration</topic><topic>Papain - therapeutic use</topic><topic>Sodium Chloride - therapeutic use</topic><topic>Streptokinase - therapeutic use</topic><topic>Temperature</topic><topic>Tissue Culture Techniques - veterinary</topic><topic>tissue repair</topic><topic>Treatment Outcome</topic><topic>Urea - therapeutic use</topic><topic>Wound Healing</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pain, R.</creatorcontrib><creatorcontrib>Sneddon, J. 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C.</au><au>Cochrane, C. A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>In vitro study of the effectiveness of different dressings for debriding fibrin in blood clots from horses</atitle><jtitle>Veterinary record</jtitle><addtitle>Vet Rec</addtitle><date>2006-11-18</date><risdate>2006</risdate><volume>159</volume><issue>21</issue><spage>712</spage><epage>717</epage><pages>712-717</pages><issn>0042-4900</issn><eissn>2042-7670</eissn><abstract>Franz diffusion cells containing uniformly dehydrated equine blood clots to simulate fibrinous eschar were used to measure the rate of debridement of fibrin by novel and traditional wound dressings, under standardised conditions of temperature, pH and humidity. Significant increases in protein breakdown occurred within 24 hours with all the dressings, but not thereafter. In general, dressings hydrated in normal saline were better as debriding agents than dressings hydrated in water. Autolytic debriding agents were 47 per cent more effective than chemical debriding agents; specifically, hydrofibre and gauze dressings hydrated in saline broke down more than 3500 μg/ml of protein whereas dressings impregnated with proteolytic enzymatic agents digested less than 1400 μg/ml.</abstract><cop>England</cop><pub>BMJ Publishing Group Limited</pub><pmid>17114382</pmid><doi>10.1136/vr.159.21.712</doi><tpages>6</tpages></addata></record> |
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| ispartof | Veterinary record, 2006-11, Vol.159 (21), p.712-717 |
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| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Animals Bandages - veterinary Bandages, Hydrocolloid - veterinary Blood Coagulation - physiology Collagenases - therapeutic use debridement Debridement - methods Debridement - veterinary fibrin Fibrin - drug effects Horses Humidity Hydrogen-Ion Concentration Papain - therapeutic use Sodium Chloride - therapeutic use Streptokinase - therapeutic use Temperature Tissue Culture Techniques - veterinary tissue repair Treatment Outcome Urea - therapeutic use Wound Healing |
| title | In vitro study of the effectiveness of different dressings for debriding fibrin in blood clots from horses |
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