Nucleocytoplasmic Shuttling of HMGB1 Is Regulated by Phosphorylation That Redirects It toward Secretion

The high mobility group box 1 (HMGB1) protein can be secreted by activated monocytes and macrophages and functions as a late mediator of sepsis. HMGB1 contains two nuclear localization signals (NLSs) for controlled nuclear transport, and acetylation of both NLSs of HMGB1 is involved in nuclear trans...

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Veröffentlicht in:	Journal of Immunology 2006-12, Vol.177 (11), p.7889-7897
Hauptverfasser:	Youn, Ju Ho, Shin, Jeon-Soo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blotting, Western Cell Line Cell Nucleus - metabolism Cytoplasm - metabolism Fluorescent Antibody Technique HMGB1 Protein - metabolism Humans Immunoprecipitation Leukocytes, Mononuclear - metabolism Mice Nuclear Localization Signals - metabolism Phosphorylation Protein Transport - physiology
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