Aberrant promoter methylation profile in pleural fluid DNA and clinicopathological factors in patients with non-small cell lung cancer
The aim of this study was to investigate the prognostic value of hypermethylation of tumor suppressor genes in patients with non-small cell lung cancer (NSCLC). In samples from 34 lung patients with malignant pleural effusions, we used a methylation-specific polymerase chain reaction to detect aberr...
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| Veröffentlicht in: | Asian Pacific journal of cancer prevention : APJCP 2007-04, Vol.8 (2), p.221-224 |
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| container_title | Asian Pacific journal of cancer prevention : APJCP |
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| creator | Katayama, Hideki Hiraki, Akio Fujiwara, Keiichi Matsuo, Keitaro Maeda, Tadashi Chikamori, Kenichi Kishino, Daizo Tajima, Kazuo Ueoka, Hiroshi Aoe, Keisuke |
| description | The aim of this study was to investigate the prognostic value of hypermethylation of tumor suppressor genes in patients with non-small cell lung cancer (NSCLC). In samples from 34 lung patients with malignant pleural effusions, we used a methylation-specific polymerase chain reaction to detect aberrant hypermethylation of the promoters of the DNA repair gene O6-methylguanine-DNA methyltransferase (MGMT), p16INK4a, ras association domain family 1A (RASSF1A), apoptosis-related genes, death-associated protein kinase (DAPK), and retinoic acid receptor beta(RARbeta). There is no association between methylation status of five tumor suppressor genes including MGMT, p16INK4a, RASSF1A, DAPK and RARbeta in pleural fluid DNA and clinicopathological parameters including clinical outcome. Aberrant promoter methylation of tumor suppressor genes in pleural fluid DNA could not be a valuable prognostic marker of NSCLC patients with malignant pleural effusion. |
| format | Article |
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In samples from 34 lung patients with malignant pleural effusions, we used a methylation-specific polymerase chain reaction to detect aberrant hypermethylation of the promoters of the DNA repair gene O6-methylguanine-DNA methyltransferase (MGMT), p16INK4a, ras association domain family 1A (RASSF1A), apoptosis-related genes, death-associated protein kinase (DAPK), and retinoic acid receptor beta(RARbeta). There is no association between methylation status of five tumor suppressor genes including MGMT, p16INK4a, RASSF1A, DAPK and RARbeta in pleural fluid DNA and clinicopathological parameters including clinical outcome. Aberrant promoter methylation of tumor suppressor genes in pleural fluid DNA could not be a valuable prognostic marker of NSCLC patients with malignant pleural effusion.</description><identifier>ISSN: 1513-7368</identifier><identifier>PMID: 17696735</identifier><language>eng</language><publisher>Thailand</publisher><subject>Carcinoma, Non-Small-Cell Lung - genetics ; Carcinoma, Non-Small-Cell Lung - mortality ; DNA Methylation ; DNA, Neoplasm - genetics ; Genes, Tumor Suppressor ; Humans ; Lung Neoplasms - genetics ; Lung Neoplasms - mortality ; Pleural Effusion, Malignant - genetics ; Pleural Effusion, Malignant - mortality ; Prognosis ; Promoter Regions, Genetic ; Survival Analysis</subject><ispartof>Asian Pacific journal of cancer prevention : APJCP, 2007-04, Vol.8 (2), p.221-224</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17696735$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Katayama, Hideki</creatorcontrib><creatorcontrib>Hiraki, Akio</creatorcontrib><creatorcontrib>Fujiwara, Keiichi</creatorcontrib><creatorcontrib>Matsuo, Keitaro</creatorcontrib><creatorcontrib>Maeda, Tadashi</creatorcontrib><creatorcontrib>Chikamori, Kenichi</creatorcontrib><creatorcontrib>Kishino, Daizo</creatorcontrib><creatorcontrib>Tajima, Kazuo</creatorcontrib><creatorcontrib>Ueoka, Hiroshi</creatorcontrib><creatorcontrib>Aoe, Keisuke</creatorcontrib><title>Aberrant promoter methylation profile in pleural fluid DNA and clinicopathological factors in patients with non-small cell lung cancer</title><title>Asian Pacific journal of cancer prevention : APJCP</title><addtitle>Asian Pac J Cancer Prev</addtitle><description>The aim of this study was to investigate the prognostic value of hypermethylation of tumor suppressor genes in patients with non-small cell lung cancer (NSCLC). In samples from 34 lung patients with malignant pleural effusions, we used a methylation-specific polymerase chain reaction to detect aberrant hypermethylation of the promoters of the DNA repair gene O6-methylguanine-DNA methyltransferase (MGMT), p16INK4a, ras association domain family 1A (RASSF1A), apoptosis-related genes, death-associated protein kinase (DAPK), and retinoic acid receptor beta(RARbeta). There is no association between methylation status of five tumor suppressor genes including MGMT, p16INK4a, RASSF1A, DAPK and RARbeta in pleural fluid DNA and clinicopathological parameters including clinical outcome. Aberrant promoter methylation of tumor suppressor genes in pleural fluid DNA could not be a valuable prognostic marker of NSCLC patients with malignant pleural effusion.</description><subject>Carcinoma, Non-Small-Cell Lung - genetics</subject><subject>Carcinoma, Non-Small-Cell Lung - mortality</subject><subject>DNA Methylation</subject><subject>DNA, Neoplasm - genetics</subject><subject>Genes, Tumor Suppressor</subject><subject>Humans</subject><subject>Lung Neoplasms - genetics</subject><subject>Lung Neoplasms - mortality</subject><subject>Pleural Effusion, Malignant - genetics</subject><subject>Pleural Effusion, Malignant - mortality</subject><subject>Prognosis</subject><subject>Promoter Regions, Genetic</subject><subject>Survival Analysis</subject><issn>1513-7368</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1kMtOwzAQRb0A0VL4BeQVu0h2HD-yrMpTqmAD68h27NbIsYPtCPUH-G5SKJuZ0dWZqztzBpaYYlJxwsQCXOb8gVBDBacXYIE5axkndAm-18qkJEOBY4pDLCbBwZT9wcviYjiK1nkD3Tx6MyXpofWT6-HdyxrK0EPtXXA6jrLso487p4-E1CWm_Ls025hQMvxyZQ9DDFUepPdQm7n4KeyglkGbdAXOrfTZXJ_6Crw_3L9tnqrt6-PzZr2txhq1pdK1thwL2zeYNaI1tdWK1BQLVbfMMq6JEnTWWaMpRwIrpLE2BKlaNpYxRFbg9s93PuxzMrl0g8vHMDKYOOWOCcwoxc0M3pzASQ2m78bkBpkO3f_nyA9eBGvv</recordid><startdate>20070401</startdate><enddate>20070401</enddate><creator>Katayama, Hideki</creator><creator>Hiraki, Akio</creator><creator>Fujiwara, Keiichi</creator><creator>Matsuo, Keitaro</creator><creator>Maeda, Tadashi</creator><creator>Chikamori, Kenichi</creator><creator>Kishino, Daizo</creator><creator>Tajima, Kazuo</creator><creator>Ueoka, Hiroshi</creator><creator>Aoe, Keisuke</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20070401</creationdate><title>Aberrant promoter methylation profile in pleural fluid DNA and clinicopathological factors in patients with non-small cell lung cancer</title><author>Katayama, Hideki ; Hiraki, Akio ; Fujiwara, Keiichi ; Matsuo, Keitaro ; Maeda, Tadashi ; Chikamori, Kenichi ; Kishino, Daizo ; Tajima, Kazuo ; Ueoka, Hiroshi ; Aoe, Keisuke</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p209t-c2cf718fd416489e2fcb32518b296f67c3b8589e64c57081b0c1ce30b2a4f6603</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Carcinoma, Non-Small-Cell Lung - genetics</topic><topic>Carcinoma, Non-Small-Cell Lung - mortality</topic><topic>DNA Methylation</topic><topic>DNA, Neoplasm - genetics</topic><topic>Genes, Tumor Suppressor</topic><topic>Humans</topic><topic>Lung Neoplasms - genetics</topic><topic>Lung Neoplasms - mortality</topic><topic>Pleural Effusion, Malignant - genetics</topic><topic>Pleural Effusion, Malignant - mortality</topic><topic>Prognosis</topic><topic>Promoter Regions, Genetic</topic><topic>Survival Analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Katayama, Hideki</creatorcontrib><creatorcontrib>Hiraki, Akio</creatorcontrib><creatorcontrib>Fujiwara, Keiichi</creatorcontrib><creatorcontrib>Matsuo, Keitaro</creatorcontrib><creatorcontrib>Maeda, Tadashi</creatorcontrib><creatorcontrib>Chikamori, Kenichi</creatorcontrib><creatorcontrib>Kishino, Daizo</creatorcontrib><creatorcontrib>Tajima, Kazuo</creatorcontrib><creatorcontrib>Ueoka, Hiroshi</creatorcontrib><creatorcontrib>Aoe, Keisuke</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Asian Pacific journal of cancer prevention : APJCP</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Katayama, Hideki</au><au>Hiraki, Akio</au><au>Fujiwara, Keiichi</au><au>Matsuo, Keitaro</au><au>Maeda, Tadashi</au><au>Chikamori, Kenichi</au><au>Kishino, Daizo</au><au>Tajima, Kazuo</au><au>Ueoka, Hiroshi</au><au>Aoe, Keisuke</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Aberrant promoter methylation profile in pleural fluid DNA and clinicopathological factors in patients with non-small cell lung cancer</atitle><jtitle>Asian Pacific journal of cancer prevention : APJCP</jtitle><addtitle>Asian Pac J Cancer Prev</addtitle><date>2007-04-01</date><risdate>2007</risdate><volume>8</volume><issue>2</issue><spage>221</spage><epage>224</epage><pages>221-224</pages><issn>1513-7368</issn><abstract>The aim of this study was to investigate the prognostic value of hypermethylation of tumor suppressor genes in patients with non-small cell lung cancer (NSCLC). In samples from 34 lung patients with malignant pleural effusions, we used a methylation-specific polymerase chain reaction to detect aberrant hypermethylation of the promoters of the DNA repair gene O6-methylguanine-DNA methyltransferase (MGMT), p16INK4a, ras association domain family 1A (RASSF1A), apoptosis-related genes, death-associated protein kinase (DAPK), and retinoic acid receptor beta(RARbeta). There is no association between methylation status of five tumor suppressor genes including MGMT, p16INK4a, RASSF1A, DAPK and RARbeta in pleural fluid DNA and clinicopathological parameters including clinical outcome. Aberrant promoter methylation of tumor suppressor genes in pleural fluid DNA could not be a valuable prognostic marker of NSCLC patients with malignant pleural effusion.</abstract><cop>Thailand</cop><pmid>17696735</pmid><tpages>4</tpages></addata></record> |
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| subjects | Carcinoma, Non-Small-Cell Lung - genetics Carcinoma, Non-Small-Cell Lung - mortality DNA Methylation DNA, Neoplasm - genetics Genes, Tumor Suppressor Humans Lung Neoplasms - genetics Lung Neoplasms - mortality Pleural Effusion, Malignant - genetics Pleural Effusion, Malignant - mortality Prognosis Promoter Regions, Genetic Survival Analysis |
| title | Aberrant promoter methylation profile in pleural fluid DNA and clinicopathological factors in patients with non-small cell lung cancer |
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