Inhibition of P-fimbriated Escherichia coli adhesion by multivalent galabiose derivatives studied by a live-bacteria application of surface plasmon resonance

Objectives Uropathogenic P-fimbriated Escherichia coli adheres to host cells by specific adhesins recognizing galabiose (Galα1-4Gal)-containing structures on cell surfaces. In search of agents inhibiting this first step of infection, the inhibition potency of a set of synthetic mono- and multivalent...

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Veröffentlicht in:	Journal of antimicrobial chemotherapy 2007-09, Vol.60 (3), p.495-501
Hauptverfasser:	Salminen, Annika, Loimaranta, Vuokko, Joosten, John A. F., Khan, A. Salam, Hacker, Jörg, Pieters, Roland J., Finne, Jukka
Format:	Artikel
Sprache:	eng
Schlagworte:	anti-adhesion Antibiotics. Antiinfectious agents. Antiparasitic agents Bacteria Bacterial Adhesion - drug effects Binding sites Biological and medical sciences Carbohydrates - chemistry Cell adhesion & migration Cellular biology Disaccharides - antagonists & inhibitors Disaccharides - pharmacology E coli Escherichia coli Escherichia coli - chemistry Escherichia coli - drug effects Escherichia coli - physiology Fimbriae, Bacterial - physiology glycodendrimers Hemagglutination Tests Medical sciences oligovalent inhibitors Pharmacology. Drug treatments Serum Albumin, Bovine - chemistry Streptococcus suis Streptococcus suis - drug effects Surface Plasmon Resonance
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