Comparative Glycomic Mapping through Quantitative Permethylation and Stable-Isotope Labeling

Comparative glycan quantification has thus far been a challenging task due to the lack of sensitive and reproducible analytical techniques. We introduce here a combination of quantitative permethylation and isotope labeling of glycans as an approach (C-GlycoMAP) allowing precise comparison between d...

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Veröffentlicht in:	Analytical chemistry (Washington) 2007-08, Vol.79 (16), p.6064-6073
Hauptverfasser:	Kang, Pilsoo, Mechref, Yehia, Kyselova, Zuzana, Goetz, John A, Novotny, Milos V
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical chemistry Body fluids Breast Neoplasms - blood Chemistry Comparative analysis Exact sciences and technology Female Humans Isotope Labeling Isotopes Methylation Polysaccharides - blood Proteins Spectrometric and optical methods Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization - methods
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