Nuclear receptor NR5A2 is required for proper primitive streak morphogenesis

NR5A2, also known as liver receptor homologue 1 (LRH‐1) and fetoprotein transcription factor (FTF), is an orphan nuclear receptor involved in the regulation of cholesterol metabolism and steroidogenesis in the adult. NR5A2 was also shown to be expressed during early mouse embryogenesis. Consistent w...

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Veröffentlicht in:	Developmental dynamics 2006-12, Vol.235 (12), p.3359-3369
Hauptverfasser:	Labelle‐Dumais, Cassandre, Jacob‐Wagner, Mariève, Paré, Jean‐Francois, Bélanger, Luc, Dufort, Daniel
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Base Sequence Body Patterning - genetics Body Patterning - physiology Chimera - genetics DNA Primers - genetics Embryonic Development - genetics Embryonic Development - physiology Endoderm - cytology Endoderm - metabolism Female Gastrula - cytology Gastrula - metabolism gastrulation GATA4 Transcription Factor - genetics Gene Expression Regulation, Developmental Genetic Markers Hepatocyte Nuclear Factor 4 - genetics Male mesoderm Mesoderm - cytology Mesoderm - metabolism Mice Mice, Knockout NR5A2 nuclear receptor Phenotype Polyploidy Pregnancy primitive streak Receptors, Cytoplasmic and Nuclear - deficiency Receptors, Cytoplasmic and Nuclear - genetics Receptors, Cytoplasmic and Nuclear - metabolism visceral endoderm
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