Abrasion of tablets during scale-up: The influence of different crushing forces in laboratory and production perforated pan coaters

The purpose of this study was to investigate the influence of batch size during scale-up on the abrasion of biconvex tablets. Labelled tracer tablets of six different crushing forces (23–116 N) were mixed at different times and peripheral speeds in a laboratory (4 kg) and production (360 kg) perfora...

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Veröffentlicht in:	European journal of pharmaceutics and biopharmaceutics 2007-09, Vol.67 (2), p.458-463
Hauptverfasser:	Mueller, Ronny, Kleinebudde, Peter
Format:	Artikel
Sprache:	eng
Schlagworte:	Abrasion Absorption Biological and medical sciences Bohle Film Coater Chemistry, Pharmaceutical - methods Drug Compounding Equipment Design General pharmacology Hardness Medical sciences Models, Statistical Pan speed Particle Size Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Pressure Scale-up Solubility Surface Properties Tablets Tablets, Enteric-Coated - chemistry Technology, Pharmaceutical - methods Time Factors
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