Low-dose ginseng (Panax quinquefolium) modulates the course and magnitude of the antibody response to vaccination against equid herpesvirus I in horses
The purpose of this study was to determine if ginseng fed at low levels enhances a horse's antibody response to vaccination against Equid herpesvirus 1 (EHV-1). For 28 d, 5 horses received ground, powdered ginseng (35 mg/kg body weight, 1.7 mg/kg total ginsenosides) in molasses as a carrier, an...
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| Veröffentlicht in: | Canadian journal of veterinary research 2007-07, Vol.71 (3), p.213-217 |
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| container_title | Canadian journal of veterinary research |
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| creator | Pearson, Wendy Omar, Semir Clarke, Andrew F |
| description | The purpose of this study was to determine if ginseng fed at low levels enhances a horse's antibody response to vaccination against Equid herpesvirus 1 (EHV-1). For 28 d, 5 horses received ground, powdered ginseng (35 mg/kg body weight, 1.7 mg/kg total ginsenosides) in molasses as a carrier, and 5 received molasses only. On day 14, each horse was vaccinated against EHV-1. The time course of the antibody response to vaccination was significantly altered in the horses receiving ginseng, a clinically relevant increase in antibody titer being observed by postvaccination day 2 compared with day 6 in the control horses. The horses receiving ginseng also had a significant decrease in serum levels of sodium and a significant increase in serum levels of potassium. No adverse effects of ginseng treatment were identified by hematologic and blood biochemistry profiles. Thus, low-dose dietary supplementation with ginseng in healthy horses may be a useful adjunct to vaccination. |
| format | Article |
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For 28 d, 5 horses received ground, powdered ginseng (35 mg/kg body weight, 1.7 mg/kg total ginsenosides) in molasses as a carrier, and 5 received molasses only. On day 14, each horse was vaccinated against EHV-1. The time course of the antibody response to vaccination was significantly altered in the horses receiving ginseng, a clinically relevant increase in antibody titer being observed by postvaccination day 2 compared with day 6 in the control horses. The horses receiving ginseng also had a significant decrease in serum levels of sodium and a significant increase in serum levels of potassium. No adverse effects of ginseng treatment were identified by hematologic and blood biochemistry profiles. 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Thus, low-dose dietary supplementation with ginseng in healthy horses may be a useful adjunct to vaccination.</description><subject>Adjuvants, Immunologic</subject><subject>Animals</subject><subject>Antibodies, Viral - blood</subject><subject>Female</subject><subject>Herpesviridae Infections - prevention & control</subject><subject>Herpesviridae Infections - veterinary</subject><subject>Herpesvirus 1, Equid - immunology</subject><subject>Herpesvirus Vaccines - immunology</subject><subject>Horse Diseases - prevention & control</subject><subject>Horses</subject><subject>Male</subject><subject>Panax - immunology</subject><subject>Potassium - blood</subject><subject>Sodium - blood</subject><subject>Vaccination - methods</subject><subject>Vaccination - veterinary</subject><issn>0830-9000</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1kMtOwzAQRb0A0VL4BTQrBItITpw4yRJVPCpVAgn20SSepEaJncZ2gS_hd4mgrGZx556jmRO25IXgUck5X7Bz5945T3KZiDO2iHNZZlmZL9n31n5EyjqCThtHpoObFzT4CfugzT5Qa3sdhlsYrAo9enLgdwSNDdNcQaNgwM5oHxSBbX8zNF7XVn3BRG60MxO8hQM2jTbotTWAHc4qDzQrFOxoGskd9BQcbEAb2NkZ7S7YaYu9o8vjXLHXh_u39VO0fX7crO-20ZileVTzjJK4poKrWCYyV00uUplygVlMhDkVcZzKTJFKCiFikai2xoxTyeuaSiVW7PqPOk52Ptb5atCuob5HQza4ShaxFOnMW7Gr42KoB1LVOOkBp6_q_5HiB5yCcc8</recordid><startdate>200707</startdate><enddate>200707</enddate><creator>Pearson, Wendy</creator><creator>Omar, Semir</creator><creator>Clarke, Andrew F</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>200707</creationdate><title>Low-dose ginseng (Panax quinquefolium) modulates the course and magnitude of the antibody response to vaccination against equid herpesvirus I in horses</title><author>Pearson, Wendy ; Omar, Semir ; Clarke, Andrew F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p547-b05e21be80d16267dc7346403a51eea7e811465ded2833132dfba50e90bbe9d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adjuvants, Immunologic</topic><topic>Animals</topic><topic>Antibodies, Viral - blood</topic><topic>Female</topic><topic>Herpesviridae Infections - prevention & control</topic><topic>Herpesviridae Infections - veterinary</topic><topic>Herpesvirus 1, Equid - immunology</topic><topic>Herpesvirus Vaccines - immunology</topic><topic>Horse Diseases - prevention & control</topic><topic>Horses</topic><topic>Male</topic><topic>Panax - immunology</topic><topic>Potassium - blood</topic><topic>Sodium - blood</topic><topic>Vaccination - methods</topic><topic>Vaccination - veterinary</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pearson, Wendy</creatorcontrib><creatorcontrib>Omar, Semir</creatorcontrib><creatorcontrib>Clarke, Andrew F</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Canadian journal of veterinary research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pearson, Wendy</au><au>Omar, Semir</au><au>Clarke, Andrew F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Low-dose ginseng (Panax quinquefolium) modulates the course and magnitude of the antibody response to vaccination against equid herpesvirus I in horses</atitle><jtitle>Canadian journal of veterinary research</jtitle><addtitle>Can J Vet Res</addtitle><date>2007-07</date><risdate>2007</risdate><volume>71</volume><issue>3</issue><spage>213</spage><epage>217</epage><pages>213-217</pages><issn>0830-9000</issn><abstract>The purpose of this study was to determine if ginseng fed at low levels enhances a horse's antibody response to vaccination against Equid herpesvirus 1 (EHV-1). 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| ispartof | Canadian journal of veterinary research, 2007-07, Vol.71 (3), p.213-217 |
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| language | eng |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Adjuvants, Immunologic Animals Antibodies, Viral - blood Female Herpesviridae Infections - prevention & control Herpesviridae Infections - veterinary Herpesvirus 1, Equid - immunology Herpesvirus Vaccines - immunology Horse Diseases - prevention & control Horses Male Panax - immunology Potassium - blood Sodium - blood Vaccination - methods Vaccination - veterinary |
| title | Low-dose ginseng (Panax quinquefolium) modulates the course and magnitude of the antibody response to vaccination against equid herpesvirus I in horses |
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