Adenovirus Type 5 Substituted with Type 11 or 35 Fiber Structure Increases its Infectivity to Human Cells Enabling Dual Gene Transfer in CD46-dependent and -independent Manners

Infectivity of adenovirus type 5 (Ad5) to cells depends primarily on its fiber-mediated binding to the coxsackievirus and adenovirus receptor (CAR) on target cells. Down-regulated CAR expression, often found in human tumors, hampered Ad5-mediated gene transfer. Ad 11 and Ad 35, belonging to a subtyp...

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