Proapoptotic factor Bax is increased in satellite cells in the tibialis anterior muscles of old rats
Aging impairs the ability of muscle to adapt to exercise or injury. The goal of this study was to determine whether age‐related changes in muscle adaptability could be the result of satellite cell apoptosis. Ten days after exposure to an injury protocol, estimates of edema in the exposed tibialis an...
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| Veröffentlicht in: | Muscle & nerve 2006-12, Vol.34 (6), p.720-730 |
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| creator | Krajnak, Kristine Waugh, Stacey Miller, Roger Baker, Brent Geronilla, Kenneth Alway, Stephen E. Cutlip, Robert G. |
| description | Aging impairs the ability of muscle to adapt to exercise or injury. The goal of this study was to determine whether age‐related changes in muscle adaptability could be the result of satellite cell apoptosis. Ten days after exposure to an injury protocol, estimates of edema in the exposed tibialis anterior muscles were higher in old (30 months) than young (3 months) rats, and isometric force levels were lower in old rats. Both young and old rats displayed an increase in MyoD labeling in the exposed muscle, indicating that injury induced satellite‐cell activation. However, there were more MyoD‐labeled cells that coexpressed the proapoptotic factor, Bax, in old than in young rats, suggesting that decrements in muscle recovery may be associated with an increase in satellite‐cell apoptosis. Based on these findings we conclude that reducing satellite‐cell apoptosis in aged animals may improve muscle recovery after injury. Muscle Nerve, 2006 |
| doi_str_mv | 10.1002/mus.20656 |
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The goal of this study was to determine whether age‐related changes in muscle adaptability could be the result of satellite cell apoptosis. Ten days after exposure to an injury protocol, estimates of edema in the exposed tibialis anterior muscles were higher in old (30 months) than young (3 months) rats, and isometric force levels were lower in old rats. Both young and old rats displayed an increase in MyoD labeling in the exposed muscle, indicating that injury induced satellite‐cell activation. However, there were more MyoD‐labeled cells that coexpressed the proapoptotic factor, Bax, in old than in young rats, suggesting that decrements in muscle recovery may be associated with an increase in satellite‐cell apoptosis. Based on these findings we conclude that reducing satellite‐cell apoptosis in aged animals may improve muscle recovery after injury. Muscle Nerve, 2006</description><identifier>ISSN: 0148-639X</identifier><identifier>EISSN: 1097-4598</identifier><identifier>DOI: 10.1002/mus.20656</identifier><identifier>PMID: 16967487</identifier><identifier>CODEN: MUNEDE</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adaptation, Physiological ; Age Factors ; aging ; Aging - genetics ; Aging - metabolism ; Aging - pathology ; Animals ; Apoptosis ; bcl-2-Associated X Protein - analysis ; bcl-2-Associated X Protein - genetics ; bcl-2-Associated X Protein - metabolism ; Biological and medical sciences ; contraction-induced injury ; Exercise Test ; Fundamental and applied biological sciences. Psychology ; Immunohistochemistry ; Isometric Contraction - genetics ; Isometric Contraction - physiology ; isometric force ; Male ; Muscle, Skeletal - cytology ; Muscle, Skeletal - injuries ; Muscle, Skeletal - physiology ; MyoD Protein - analysis ; MyoD Protein - metabolism ; Organ Size ; Rats ; Rats, Inbred Strains ; Regeneration ; Reverse Transcriptase Polymerase Chain Reaction ; RNA, Messenger - analysis ; satellite cells ; Satellite Cells, Skeletal Muscle - cytology ; Satellite Cells, Skeletal Muscle - metabolism ; Satellite Cells, Skeletal Muscle - physiology ; Striated muscle. Tendons ; Transcription, Genetic ; Up-Regulation ; Vertebrates: osteoarticular system, musculoskeletal system</subject><ispartof>Muscle & nerve, 2006-12, Vol.34 (6), p.720-730</ispartof><rights>Copyright © 2006 Wiley Periodicals, Inc.</rights><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4576-998c7a5da2272731a627ee647ae2a90fe997569e4653478d3df7669c450beefa3</citedby><cites>FETCH-LOGICAL-c4576-998c7a5da2272731a627ee647ae2a90fe997569e4653478d3df7669c450beefa3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fmus.20656$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fmus.20656$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18343959$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16967487$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Krajnak, Kristine</creatorcontrib><creatorcontrib>Waugh, Stacey</creatorcontrib><creatorcontrib>Miller, Roger</creatorcontrib><creatorcontrib>Baker, Brent</creatorcontrib><creatorcontrib>Geronilla, Kenneth</creatorcontrib><creatorcontrib>Alway, Stephen E.</creatorcontrib><creatorcontrib>Cutlip, Robert G.</creatorcontrib><title>Proapoptotic factor Bax is increased in satellite cells in the tibialis anterior muscles of old rats</title><title>Muscle & nerve</title><addtitle>Muscle Nerve</addtitle><description>Aging impairs the ability of muscle to adapt to exercise or injury. The goal of this study was to determine whether age‐related changes in muscle adaptability could be the result of satellite cell apoptosis. Ten days after exposure to an injury protocol, estimates of edema in the exposed tibialis anterior muscles were higher in old (30 months) than young (3 months) rats, and isometric force levels were lower in old rats. Both young and old rats displayed an increase in MyoD labeling in the exposed muscle, indicating that injury induced satellite‐cell activation. However, there were more MyoD‐labeled cells that coexpressed the proapoptotic factor, Bax, in old than in young rats, suggesting that decrements in muscle recovery may be associated with an increase in satellite‐cell apoptosis. Based on these findings we conclude that reducing satellite‐cell apoptosis in aged animals may improve muscle recovery after injury. Muscle Nerve, 2006</description><subject>Adaptation, Physiological</subject><subject>Age Factors</subject><subject>aging</subject><subject>Aging - genetics</subject><subject>Aging - metabolism</subject><subject>Aging - pathology</subject><subject>Animals</subject><subject>Apoptosis</subject><subject>bcl-2-Associated X Protein - analysis</subject><subject>bcl-2-Associated X Protein - genetics</subject><subject>bcl-2-Associated X Protein - metabolism</subject><subject>Biological and medical sciences</subject><subject>contraction-induced injury</subject><subject>Exercise Test</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Immunohistochemistry</subject><subject>Isometric Contraction - genetics</subject><subject>Isometric Contraction - physiology</subject><subject>isometric force</subject><subject>Male</subject><subject>Muscle, Skeletal - cytology</subject><subject>Muscle, Skeletal - injuries</subject><subject>Muscle, Skeletal - physiology</subject><subject>MyoD Protein - analysis</subject><subject>MyoD Protein - metabolism</subject><subject>Organ Size</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Regeneration</subject><subject>Reverse Transcriptase Polymerase Chain Reaction</subject><subject>RNA, Messenger - analysis</subject><subject>satellite cells</subject><subject>Satellite Cells, Skeletal Muscle - cytology</subject><subject>Satellite Cells, Skeletal Muscle - metabolism</subject><subject>Satellite Cells, Skeletal Muscle - physiology</subject><subject>Striated muscle. Tendons</subject><subject>Transcription, Genetic</subject><subject>Up-Regulation</subject><subject>Vertebrates: osteoarticular system, musculoskeletal system</subject><issn>0148-639X</issn><issn>1097-4598</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kE9vEzEQxa2KiobCgS-AfKESh23t9b_1kbSkRW0BCapysybeWWHYxKntiPbb1yGBnjjNSPN7M28eIa85O-aMtSeLdT5umVZ6j0w4s6aRynbPyIRx2TVa2O8H5EXOPxljvNPmOTng2mojOzMh_ZcUYRVXJZbg6QC-xESncE9DpmHpE0LGvnY0Q8FxDAWpr3UzpOUH0hLmAcYKw7JgClVczfgRM40DjWNPE5T8kuwPMGZ8tauH5Gb24dvpRXP1-fzj6furxktldGNt5w2oHtrWtEZw0K1B1NIAtmDZgNYapS1KrYQ0XS_6wWhtq5jNEQcQh-Rou3eV4t0ac3GLkDd2YYlxnZ3uuG6lVRV8twV9ijknHNwqhQWkB8eZ20Tq6hfuT6SVfbNbup4vsH8idxlW4O0OgOxhHBIsfchPXCeksMpW7mTL_Q4jPvz_oru--fr3dLNVhFzw_p8C0i-njTDK3X46d9MZU5fXZ1M3E4_z9p0T</recordid><startdate>200612</startdate><enddate>200612</enddate><creator>Krajnak, Kristine</creator><creator>Waugh, Stacey</creator><creator>Miller, Roger</creator><creator>Baker, Brent</creator><creator>Geronilla, Kenneth</creator><creator>Alway, Stephen E.</creator><creator>Cutlip, Robert G.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200612</creationdate><title>Proapoptotic factor Bax is increased in satellite cells in the tibialis anterior muscles of old rats</title><author>Krajnak, Kristine ; Waugh, Stacey ; Miller, Roger ; Baker, Brent ; Geronilla, Kenneth ; Alway, Stephen E. ; Cutlip, Robert G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4576-998c7a5da2272731a627ee647ae2a90fe997569e4653478d3df7669c450beefa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Adaptation, Physiological</topic><topic>Age Factors</topic><topic>aging</topic><topic>Aging - genetics</topic><topic>Aging - metabolism</topic><topic>Aging - pathology</topic><topic>Animals</topic><topic>Apoptosis</topic><topic>bcl-2-Associated X Protein - analysis</topic><topic>bcl-2-Associated X Protein - genetics</topic><topic>bcl-2-Associated X Protein - metabolism</topic><topic>Biological and medical sciences</topic><topic>contraction-induced injury</topic><topic>Exercise Test</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Immunohistochemistry</topic><topic>Isometric Contraction - genetics</topic><topic>Isometric Contraction - physiology</topic><topic>isometric force</topic><topic>Male</topic><topic>Muscle, Skeletal - cytology</topic><topic>Muscle, Skeletal - injuries</topic><topic>Muscle, Skeletal - physiology</topic><topic>MyoD Protein - analysis</topic><topic>MyoD Protein - metabolism</topic><topic>Organ Size</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Regeneration</topic><topic>Reverse Transcriptase Polymerase Chain Reaction</topic><topic>RNA, Messenger - analysis</topic><topic>satellite cells</topic><topic>Satellite Cells, Skeletal Muscle - cytology</topic><topic>Satellite Cells, Skeletal Muscle - metabolism</topic><topic>Satellite Cells, Skeletal Muscle - physiology</topic><topic>Striated muscle. Tendons</topic><topic>Transcription, Genetic</topic><topic>Up-Regulation</topic><topic>Vertebrates: osteoarticular system, musculoskeletal system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Krajnak, Kristine</creatorcontrib><creatorcontrib>Waugh, Stacey</creatorcontrib><creatorcontrib>Miller, Roger</creatorcontrib><creatorcontrib>Baker, Brent</creatorcontrib><creatorcontrib>Geronilla, Kenneth</creatorcontrib><creatorcontrib>Alway, Stephen E.</creatorcontrib><creatorcontrib>Cutlip, Robert G.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Muscle & nerve</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Krajnak, Kristine</au><au>Waugh, Stacey</au><au>Miller, Roger</au><au>Baker, Brent</au><au>Geronilla, Kenneth</au><au>Alway, Stephen E.</au><au>Cutlip, Robert G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Proapoptotic factor Bax is increased in satellite cells in the tibialis anterior muscles of old rats</atitle><jtitle>Muscle & nerve</jtitle><addtitle>Muscle Nerve</addtitle><date>2006-12</date><risdate>2006</risdate><volume>34</volume><issue>6</issue><spage>720</spage><epage>730</epage><pages>720-730</pages><issn>0148-639X</issn><eissn>1097-4598</eissn><coden>MUNEDE</coden><abstract>Aging impairs the ability of muscle to adapt to exercise or injury. The goal of this study was to determine whether age‐related changes in muscle adaptability could be the result of satellite cell apoptosis. Ten days after exposure to an injury protocol, estimates of edema in the exposed tibialis anterior muscles were higher in old (30 months) than young (3 months) rats, and isometric force levels were lower in old rats. Both young and old rats displayed an increase in MyoD labeling in the exposed muscle, indicating that injury induced satellite‐cell activation. However, there were more MyoD‐labeled cells that coexpressed the proapoptotic factor, Bax, in old than in young rats, suggesting that decrements in muscle recovery may be associated with an increase in satellite‐cell apoptosis. Based on these findings we conclude that reducing satellite‐cell apoptosis in aged animals may improve muscle recovery after injury. Muscle Nerve, 2006</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>16967487</pmid><doi>10.1002/mus.20656</doi><tpages>11</tpages></addata></record> |
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| subjects | Adaptation, Physiological Age Factors aging Aging - genetics Aging - metabolism Aging - pathology Animals Apoptosis bcl-2-Associated X Protein - analysis bcl-2-Associated X Protein - genetics bcl-2-Associated X Protein - metabolism Biological and medical sciences contraction-induced injury Exercise Test Fundamental and applied biological sciences. Psychology Immunohistochemistry Isometric Contraction - genetics Isometric Contraction - physiology isometric force Male Muscle, Skeletal - cytology Muscle, Skeletal - injuries Muscle, Skeletal - physiology MyoD Protein - analysis MyoD Protein - metabolism Organ Size Rats Rats, Inbred Strains Regeneration Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - analysis satellite cells Satellite Cells, Skeletal Muscle - cytology Satellite Cells, Skeletal Muscle - metabolism Satellite Cells, Skeletal Muscle - physiology Striated muscle. Tendons Transcription, Genetic Up-Regulation Vertebrates: osteoarticular system, musculoskeletal system |
| title | Proapoptotic factor Bax is increased in satellite cells in the tibialis anterior muscles of old rats |
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