Homocysteine levels in adolescent schizophrenia patients
Homocysteine is a sulfur containing amino acid that has been widely investigated for its putative role in cardiovascular and neuropsychiatric disorders. It has been suggested that homocysteine has implications especially in young, male schizophrenia patients. In this prospective case-control study,...
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| Veröffentlicht in: | European neuropsychopharmacology 2006-12, Vol.16 (8), p.588-591 |
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| container_title | European neuropsychopharmacology |
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| creator | Nevo, G. Adler Meged, S. Sela, B.A. Hanoch-Levi, A. Hershko, R. Weizman, A. |
| description | Homocysteine is a sulfur containing amino acid that has been widely investigated for its putative role in cardiovascular and neuropsychiatric disorders. It has been suggested that homocysteine has implications especially in young, male schizophrenia patients. In this prospective case-control study, we compared plasma homocysteine levels in a group of adolescent schizophrenia inpatients (aged 14–21 years; n=23) to normal healthy controls (n=51). Mean plasma homocysteine levels were significantly higher in the patient group than in the control group (15.40±2.00 and 9.78±0.33 μmol/L, respectively, p |
| doi_str_mv | 10.1016/j.euroneuro.2006.03.006 |
| format | Article |
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Adler ; Meged, S. ; Sela, B.A. ; Hanoch-Levi, A. ; Hershko, R. ; Weizman, A.</creator><creatorcontrib>Nevo, G. Adler ; Meged, S. ; Sela, B.A. ; Hanoch-Levi, A. ; Hershko, R. ; Weizman, A.</creatorcontrib><description>Homocysteine is a sulfur containing amino acid that has been widely investigated for its putative role in cardiovascular and neuropsychiatric disorders. It has been suggested that homocysteine has implications especially in young, male schizophrenia patients. In this prospective case-control study, we compared plasma homocysteine levels in a group of adolescent schizophrenia inpatients (aged 14–21 years; n=23) to normal healthy controls (n=51). Mean plasma homocysteine levels were significantly higher in the patient group than in the control group (15.40±2.00 and 9.78±0.33 μmol/L, respectively, p<0.032). The difference was almost entirely attributable to the male schizophrenia subgroup (18.18±5.65 in male patients vs. 10.31±5.33 μmol/L in female patients). The group×sex interaction was statistically significant (p=0.0035). These data indicate that a subgroup of male adolescent schizophrenia patients has high homocysteine blood levels. The role of homocysteine in the pathophysiology of adolescent-onset schizophrenia merits further investigation.</description><identifier>ISSN: 0924-977X</identifier><identifier>EISSN: 1873-7862</identifier><identifier>DOI: 10.1016/j.euroneuro.2006.03.006</identifier><identifier>PMID: 16647249</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Adolescent ; Adolescents ; Adult ; Analysis of Variance ; Case-Control Studies ; Chromatography, High Pressure Liquid - methods ; Female ; Homocysteine ; Homocysteine - blood ; Humans ; Male ; Neurodevelopment ; Prospective Studies ; Psychosis ; Schizophrenia ; Schizophrenia - blood</subject><ispartof>European neuropsychopharmacology, 2006-12, Vol.16 (8), p.588-591</ispartof><rights>2006 Elsevier B.V. and ECNP</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c369t-34e511c1d21933417b7b1e78bf102e529e2016b17e5c290a0988a7621bdbcc403</citedby><cites>FETCH-LOGICAL-c369t-34e511c1d21933417b7b1e78bf102e529e2016b17e5c290a0988a7621bdbcc403</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.euroneuro.2006.03.006$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16647249$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nevo, G. Adler</creatorcontrib><creatorcontrib>Meged, S.</creatorcontrib><creatorcontrib>Sela, B.A.</creatorcontrib><creatorcontrib>Hanoch-Levi, A.</creatorcontrib><creatorcontrib>Hershko, R.</creatorcontrib><creatorcontrib>Weizman, A.</creatorcontrib><title>Homocysteine levels in adolescent schizophrenia patients</title><title>European neuropsychopharmacology</title><addtitle>Eur Neuropsychopharmacol</addtitle><description>Homocysteine is a sulfur containing amino acid that has been widely investigated for its putative role in cardiovascular and neuropsychiatric disorders. It has been suggested that homocysteine has implications especially in young, male schizophrenia patients. In this prospective case-control study, we compared plasma homocysteine levels in a group of adolescent schizophrenia inpatients (aged 14–21 years; n=23) to normal healthy controls (n=51). Mean plasma homocysteine levels were significantly higher in the patient group than in the control group (15.40±2.00 and 9.78±0.33 μmol/L, respectively, p<0.032). The difference was almost entirely attributable to the male schizophrenia subgroup (18.18±5.65 in male patients vs. 10.31±5.33 μmol/L in female patients). The group×sex interaction was statistically significant (p=0.0035). These data indicate that a subgroup of male adolescent schizophrenia patients has high homocysteine blood levels. The role of homocysteine in the pathophysiology of adolescent-onset schizophrenia merits further investigation.</description><subject>Adolescent</subject><subject>Adolescents</subject><subject>Adult</subject><subject>Analysis of Variance</subject><subject>Case-Control Studies</subject><subject>Chromatography, High Pressure Liquid - methods</subject><subject>Female</subject><subject>Homocysteine</subject><subject>Homocysteine - blood</subject><subject>Humans</subject><subject>Male</subject><subject>Neurodevelopment</subject><subject>Prospective Studies</subject><subject>Psychosis</subject><subject>Schizophrenia</subject><subject>Schizophrenia - blood</subject><issn>0924-977X</issn><issn>1873-7862</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkF9LwzAUxYMobk6_gvbJt9bcpE2axzHUCQNfFHwLbXrHMtpmJu1AP70ZG_royz1wOef--RFyBzQDCuJhm-HoXX8oGaNUZJRnUc7IFErJU1kKdk6mVLE8VVJ-TMhVCFtKoeBcXZIJCJFLlqspKZeuc-YrDGh7TFrcYxsS2ydV41oMBvshCWZjv91u47G3VbKrBhu74ZpcrKs24M1JZ-T96fFtsUxXr88vi_kqNVyoIeU5FgAGGgaK8xxkLWtAWdZroAwLppDFf2qQWBimaEVVWVZSMKib2pic8hm5P87defc5Yhh0Z-NdbVv16MagRQkCSi6iUR6NxrsQPK71ztuu8l8aqD5A01v9C00foGnKdZSYvD2tGOsOm7_ciVI0zI-GCAf3Fr0OJkIw2FiPZtCNs_8u-QFMQoJS</recordid><startdate>200612</startdate><enddate>200612</enddate><creator>Nevo, G. 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Adler ; Meged, S. ; Sela, B.A. ; Hanoch-Levi, A. ; Hershko, R. ; Weizman, A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c369t-34e511c1d21933417b7b1e78bf102e529e2016b17e5c290a0988a7621bdbcc403</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Adolescent</topic><topic>Adolescents</topic><topic>Adult</topic><topic>Analysis of Variance</topic><topic>Case-Control Studies</topic><topic>Chromatography, High Pressure Liquid - methods</topic><topic>Female</topic><topic>Homocysteine</topic><topic>Homocysteine - blood</topic><topic>Humans</topic><topic>Male</topic><topic>Neurodevelopment</topic><topic>Prospective Studies</topic><topic>Psychosis</topic><topic>Schizophrenia</topic><topic>Schizophrenia - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nevo, G. Adler</creatorcontrib><creatorcontrib>Meged, S.</creatorcontrib><creatorcontrib>Sela, B.A.</creatorcontrib><creatorcontrib>Hanoch-Levi, A.</creatorcontrib><creatorcontrib>Hershko, R.</creatorcontrib><creatorcontrib>Weizman, A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European neuropsychopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nevo, G. Adler</au><au>Meged, S.</au><au>Sela, B.A.</au><au>Hanoch-Levi, A.</au><au>Hershko, R.</au><au>Weizman, A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Homocysteine levels in adolescent schizophrenia patients</atitle><jtitle>European neuropsychopharmacology</jtitle><addtitle>Eur Neuropsychopharmacol</addtitle><date>2006-12</date><risdate>2006</risdate><volume>16</volume><issue>8</issue><spage>588</spage><epage>591</epage><pages>588-591</pages><issn>0924-977X</issn><eissn>1873-7862</eissn><abstract>Homocysteine is a sulfur containing amino acid that has been widely investigated for its putative role in cardiovascular and neuropsychiatric disorders. It has been suggested that homocysteine has implications especially in young, male schizophrenia patients. In this prospective case-control study, we compared plasma homocysteine levels in a group of adolescent schizophrenia inpatients (aged 14–21 years; n=23) to normal healthy controls (n=51). Mean plasma homocysteine levels were significantly higher in the patient group than in the control group (15.40±2.00 and 9.78±0.33 μmol/L, respectively, p<0.032). The difference was almost entirely attributable to the male schizophrenia subgroup (18.18±5.65 in male patients vs. 10.31±5.33 μmol/L in female patients). The group×sex interaction was statistically significant (p=0.0035). These data indicate that a subgroup of male adolescent schizophrenia patients has high homocysteine blood levels. The role of homocysteine in the pathophysiology of adolescent-onset schizophrenia merits further investigation.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>16647249</pmid><doi>10.1016/j.euroneuro.2006.03.006</doi><tpages>4</tpages></addata></record> |
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| subjects | Adolescent Adolescents Adult Analysis of Variance Case-Control Studies Chromatography, High Pressure Liquid - methods Female Homocysteine Homocysteine - blood Humans Male Neurodevelopment Prospective Studies Psychosis Schizophrenia Schizophrenia - blood |
| title | Homocysteine levels in adolescent schizophrenia patients |
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