Regulation of c-Ret in the developing kidney is responsive to Pax2 gene dosage

During kidney development, Pax2 and Pax8 are expressed very early in the mammalian nephric duct and both precede the expression of receptor tyrosine kinase, c-Ret. However, in Pax2−/− mutant mice, expression of c-Ret is lost after embryonic day 10.5. As the Ret/Gdnf pathway is necessary for renal de...

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Veröffentlicht in:	Human molecular genetics 2006-12, Vol.15 (23), p.3420-3428
Hauptverfasser:	Clarke, Jason C., Patel, Sanjeevkumar R., Raymond, Richard M., Andrew, Scott, Robinson, Bruce G., Dressler, Gregory R., Brophy, Patrick D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Fundamental and applied biological sciences. Psychology Gene Dosage Gene Expression Regulation, Developmental Genetics of eukaryotes. Biological and molecular evolution Glial Cell Line-Derived Neurotrophic Factor - genetics Glial Cell Line-Derived Neurotrophic Factor - metabolism Heterozygote Humans Kidney - abnormalities Kidney - growth & development Kidney - metabolism Mice Mice, Knockout Molecular and cellular biology Morphogenesis PAX2 Transcription Factor - genetics PAX2 Transcription Factor - metabolism Promoter Regions, Genetic Proto-Oncogene Proteins c-ret - genetics
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