RB Loss Promotes Aberrant Ploidy by Deregulating Levels and Activity of DNA Replication Factors

The retinoblastoma tumor suppressor (RB) is functionally inactivated in many human cancers. Classically, RB functions to repress E2F-mediated transcription and inhibit cell cycle progression. Consequently, RB ablation leads to loss of cell cycle control and aberrant expression of E2F target genes. E...

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