Arabinoxylan Fibre Consumption Improved Glucose Metabolism, but did not Affect Serum Adipokines in Subjects with Impaired Glucose Tolerance
Abstract The consumption of arabinoxylan, a soluble fibre fraction, has been shown to improve glycemic control in type 2 diabetic subjects. Soluble dietary fibre may modulate gastrointestinal or adipose tissue hormones regulating food intake. The present study investigated the effects of arabinoxyla...
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| Veröffentlicht in: | Hormone and metabolic research 2006-11, Vol.38 (11), p.761-766 |
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| creator | Garcia, A. L. Steiniger, J. Reich, S. C. Weickert, M. O. Harsch, I. Machowetz, A. Mohlig, M. Spranger, J. Rudovich, N. N. Meuser, F. Doerfer, J. Katz, N. Speth, M. Zunft, H. J. F. Pfeiffer, A. H. F. Koebnick, C. |
| description | Abstract
The consumption of arabinoxylan, a soluble fibre fraction, has been shown to improve glycemic control in type 2 diabetic subjects. Soluble dietary fibre may modulate gastrointestinal or adipose tissue hormones regulating food intake. The present study investigated the effects of arabinoxylan consumption on serum glucose, insulin, lipids, leptin, adiponectin and resistin in subjects with impaired glucose tolerance. In a randomized, single-blind, controlled, crossover intervention trial, 11 adults consumed white bread rolls as either placebo or supplemented with 15 g arabinoxylan for 6 weeks with a 6-week washout period. Fasting serum glucose, insulin, triglycerides, unesterified fatty acids, apolipoprotein A1 and B, adiponectin, resistin and leptin were assessed before and after intervention. Fasting serum glucose, serum triglycerides and apolipoprotein A-1 were significantly lower during arabinoxylan consumption compared to placebo (p=0.029, p=0.047; p=0.029, respectively). No effects of arabinoxylan were observed for insulin, adiponectin, leptin and resistin as well as for apolipoprotein B, and unesterified fatty acids. In conclusion, the consumption of AX in subjects with impaired glucose tolerance improved fasting serum glucose, and triglycerides. However, this beneficial effect was not accompanied by changes in fasting adipokine concentrations. |
| doi_str_mv | 10.1055/s-2006-955089 |
| format | Article |
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The consumption of arabinoxylan, a soluble fibre fraction, has been shown to improve glycemic control in type 2 diabetic subjects. Soluble dietary fibre may modulate gastrointestinal or adipose tissue hormones regulating food intake. The present study investigated the effects of arabinoxylan consumption on serum glucose, insulin, lipids, leptin, adiponectin and resistin in subjects with impaired glucose tolerance. In a randomized, single-blind, controlled, crossover intervention trial, 11 adults consumed white bread rolls as either placebo or supplemented with 15 g arabinoxylan for 6 weeks with a 6-week washout period. Fasting serum glucose, insulin, triglycerides, unesterified fatty acids, apolipoprotein A1 and B, adiponectin, resistin and leptin were assessed before and after intervention. Fasting serum glucose, serum triglycerides and apolipoprotein A-1 were significantly lower during arabinoxylan consumption compared to placebo (p=0.029, p=0.047; p=0.029, respectively). No effects of arabinoxylan were observed for insulin, adiponectin, leptin and resistin as well as for apolipoprotein B, and unesterified fatty acids. In conclusion, the consumption of AX in subjects with impaired glucose tolerance improved fasting serum glucose, and triglycerides. However, this beneficial effect was not accompanied by changes in fasting adipokine concentrations.</description><identifier>ISSN: 0018-5043</identifier><identifier>EISSN: 1439-4286</identifier><identifier>DOI: 10.1055/s-2006-955089</identifier><identifier>PMID: 17111305</identifier><language>eng</language><publisher>Germany</publisher><subject>Adiponectin - blood ; Adult ; Aged ; Blood Glucose - metabolism ; Body Composition - physiology ; Body Mass Index ; Cholesterol - blood ; Dietary Fiber - therapeutic use ; Female ; Glucose - metabolism ; Glucose Intolerance - drug therapy ; Glucose Intolerance - metabolism ; Glycated Hemoglobin A - metabolism ; Humans ; Insulin - blood ; Leptin - blood ; Lipids - blood ; Male ; Middle Aged ; Original Clinical ; Resistin - blood ; Single-Blind Method ; Triglycerides - blood ; Xylans - therapeutic use</subject><ispartof>Hormone and metabolic research, 2006-11, Vol.38 (11), p.761-766</ispartof><rights>Georg Thieme Verlag KG Stuttgart · New York</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c328t-9740198a1feaf9a5d7a3b2049f3aa51945c1d89779c8ad501d7b3d47e7e12a413</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-2006-955089.pdf$$EPDF$$P50$$Gthieme$$H</linktopdf><linktohtml>$$Uhttps://www.thieme-connect.de/products/ejournals/html/10.1055/s-2006-955089$$EHTML$$P50$$Gthieme$$H</linktohtml><link.rule.ids>314,776,780,3004,3005,27901,27902,54534,54535</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17111305$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Garcia, A. L.</creatorcontrib><creatorcontrib>Steiniger, J.</creatorcontrib><creatorcontrib>Reich, S. C.</creatorcontrib><creatorcontrib>Weickert, M. O.</creatorcontrib><creatorcontrib>Harsch, I.</creatorcontrib><creatorcontrib>Machowetz, A.</creatorcontrib><creatorcontrib>Mohlig, M.</creatorcontrib><creatorcontrib>Spranger, J.</creatorcontrib><creatorcontrib>Rudovich, N. N.</creatorcontrib><creatorcontrib>Meuser, F.</creatorcontrib><creatorcontrib>Doerfer, J.</creatorcontrib><creatorcontrib>Katz, N.</creatorcontrib><creatorcontrib>Speth, M.</creatorcontrib><creatorcontrib>Zunft, H. J. F.</creatorcontrib><creatorcontrib>Pfeiffer, A. H. F.</creatorcontrib><creatorcontrib>Koebnick, C.</creatorcontrib><title>Arabinoxylan Fibre Consumption Improved Glucose Metabolism, but did not Affect Serum Adipokines in Subjects with Impaired Glucose Tolerance</title><title>Hormone and metabolic research</title><addtitle>Horm Metab Res</addtitle><description>Abstract
The consumption of arabinoxylan, a soluble fibre fraction, has been shown to improve glycemic control in type 2 diabetic subjects. Soluble dietary fibre may modulate gastrointestinal or adipose tissue hormones regulating food intake. The present study investigated the effects of arabinoxylan consumption on serum glucose, insulin, lipids, leptin, adiponectin and resistin in subjects with impaired glucose tolerance. In a randomized, single-blind, controlled, crossover intervention trial, 11 adults consumed white bread rolls as either placebo or supplemented with 15 g arabinoxylan for 6 weeks with a 6-week washout period. Fasting serum glucose, insulin, triglycerides, unesterified fatty acids, apolipoprotein A1 and B, adiponectin, resistin and leptin were assessed before and after intervention. Fasting serum glucose, serum triglycerides and apolipoprotein A-1 were significantly lower during arabinoxylan consumption compared to placebo (p=0.029, p=0.047; p=0.029, respectively). No effects of arabinoxylan were observed for insulin, adiponectin, leptin and resistin as well as for apolipoprotein B, and unesterified fatty acids. In conclusion, the consumption of AX in subjects with impaired glucose tolerance improved fasting serum glucose, and triglycerides. However, this beneficial effect was not accompanied by changes in fasting adipokine concentrations.</description><subject>Adiponectin - blood</subject><subject>Adult</subject><subject>Aged</subject><subject>Blood Glucose - metabolism</subject><subject>Body Composition - physiology</subject><subject>Body Mass Index</subject><subject>Cholesterol - blood</subject><subject>Dietary Fiber - therapeutic use</subject><subject>Female</subject><subject>Glucose - metabolism</subject><subject>Glucose Intolerance - drug therapy</subject><subject>Glucose Intolerance - metabolism</subject><subject>Glycated Hemoglobin A - metabolism</subject><subject>Humans</subject><subject>Insulin - blood</subject><subject>Leptin - blood</subject><subject>Lipids - blood</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Original Clinical</subject><subject>Resistin - blood</subject><subject>Single-Blind Method</subject><subject>Triglycerides - blood</subject><subject>Xylans - therapeutic use</subject><issn>0018-5043</issn><issn>1439-4286</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kE1P3DAQQK2qVdkCR66VT5wIeBI7iY-rVaFIIA7Qs-XEE-ElsRd_UPgN_Gmy2pXKpafRaJ6eNI-QE2DnwIS4iEXJWF1IIVgrv5AF8EoWvGzrr2TBGLSFYLw6ID9iXM8rl8C_kwNoAKBiYkHel0F31vnXt1E7emm7gHTlXczTJlnv6PW0Cf4FDb0ac-8j0ltMuvOjjdMZ7XKixhrqfKLLYcA-0XsMeaJLYzf-yTqM1Dp6n7v1fIv0r02PW6O24ZPxwY8YtOvxiHwb9BjxeD8PyZ_LXw-r38XN3dX1anlT9FXZpkI2nIFsNQyoB6mFaXTVlYzLodJagOSiB9PKppF9q41gYJquMrzBBqHUHKpDcrrzzq89Z4xJTTb2OM4F0Oeo6hZqJut6Bosd2AcfY8BBbYKddHhTwNS2vopqW1_t6s_8z704dxOaf_Q-9wyc7YD0aHFCtfY5uPnV__g-ADr2j2A</recordid><startdate>20061101</startdate><enddate>20061101</enddate><creator>Garcia, A. L.</creator><creator>Steiniger, J.</creator><creator>Reich, S. C.</creator><creator>Weickert, M. O.</creator><creator>Harsch, I.</creator><creator>Machowetz, A.</creator><creator>Mohlig, M.</creator><creator>Spranger, J.</creator><creator>Rudovich, N. N.</creator><creator>Meuser, F.</creator><creator>Doerfer, J.</creator><creator>Katz, N.</creator><creator>Speth, M.</creator><creator>Zunft, H. J. F.</creator><creator>Pfeiffer, A. H. F.</creator><creator>Koebnick, C.</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20061101</creationdate><title>Arabinoxylan Fibre Consumption Improved Glucose Metabolism, but did not Affect Serum Adipokines in Subjects with Impaired Glucose Tolerance</title><author>Garcia, A. L. ; Steiniger, J. ; Reich, S. C. ; Weickert, M. O. ; Harsch, I. ; Machowetz, A. ; Mohlig, M. ; Spranger, J. ; Rudovich, N. N. ; Meuser, F. ; Doerfer, J. ; Katz, N. ; Speth, M. ; Zunft, H. J. F. ; Pfeiffer, A. H. F. ; Koebnick, C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c328t-9740198a1feaf9a5d7a3b2049f3aa51945c1d89779c8ad501d7b3d47e7e12a413</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Adiponectin - blood</topic><topic>Adult</topic><topic>Aged</topic><topic>Blood Glucose - metabolism</topic><topic>Body Composition - physiology</topic><topic>Body Mass Index</topic><topic>Cholesterol - blood</topic><topic>Dietary Fiber - therapeutic use</topic><topic>Female</topic><topic>Glucose - metabolism</topic><topic>Glucose Intolerance - drug therapy</topic><topic>Glucose Intolerance - metabolism</topic><topic>Glycated Hemoglobin A - metabolism</topic><topic>Humans</topic><topic>Insulin - blood</topic><topic>Leptin - blood</topic><topic>Lipids - blood</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Original Clinical</topic><topic>Resistin - blood</topic><topic>Single-Blind Method</topic><topic>Triglycerides - blood</topic><topic>Xylans - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Garcia, A. 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F.</creatorcontrib><creatorcontrib>Koebnick, C.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Hormone and metabolic research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Garcia, A. L.</au><au>Steiniger, J.</au><au>Reich, S. C.</au><au>Weickert, M. O.</au><au>Harsch, I.</au><au>Machowetz, A.</au><au>Mohlig, M.</au><au>Spranger, J.</au><au>Rudovich, N. N.</au><au>Meuser, F.</au><au>Doerfer, J.</au><au>Katz, N.</au><au>Speth, M.</au><au>Zunft, H. J. F.</au><au>Pfeiffer, A. H. F.</au><au>Koebnick, C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Arabinoxylan Fibre Consumption Improved Glucose Metabolism, but did not Affect Serum Adipokines in Subjects with Impaired Glucose Tolerance</atitle><jtitle>Hormone and metabolic research</jtitle><addtitle>Horm Metab Res</addtitle><date>2006-11-01</date><risdate>2006</risdate><volume>38</volume><issue>11</issue><spage>761</spage><epage>766</epage><pages>761-766</pages><issn>0018-5043</issn><eissn>1439-4286</eissn><abstract>Abstract
The consumption of arabinoxylan, a soluble fibre fraction, has been shown to improve glycemic control in type 2 diabetic subjects. Soluble dietary fibre may modulate gastrointestinal or adipose tissue hormones regulating food intake. The present study investigated the effects of arabinoxylan consumption on serum glucose, insulin, lipids, leptin, adiponectin and resistin in subjects with impaired glucose tolerance. In a randomized, single-blind, controlled, crossover intervention trial, 11 adults consumed white bread rolls as either placebo or supplemented with 15 g arabinoxylan for 6 weeks with a 6-week washout period. Fasting serum glucose, insulin, triglycerides, unesterified fatty acids, apolipoprotein A1 and B, adiponectin, resistin and leptin were assessed before and after intervention. Fasting serum glucose, serum triglycerides and apolipoprotein A-1 were significantly lower during arabinoxylan consumption compared to placebo (p=0.029, p=0.047; p=0.029, respectively). No effects of arabinoxylan were observed for insulin, adiponectin, leptin and resistin as well as for apolipoprotein B, and unesterified fatty acids. In conclusion, the consumption of AX in subjects with impaired glucose tolerance improved fasting serum glucose, and triglycerides. However, this beneficial effect was not accompanied by changes in fasting adipokine concentrations.</abstract><cop>Germany</cop><pmid>17111305</pmid><doi>10.1055/s-2006-955089</doi><tpages>6</tpages></addata></record> |
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| subjects | Adiponectin - blood Adult Aged Blood Glucose - metabolism Body Composition - physiology Body Mass Index Cholesterol - blood Dietary Fiber - therapeutic use Female Glucose - metabolism Glucose Intolerance - drug therapy Glucose Intolerance - metabolism Glycated Hemoglobin A - metabolism Humans Insulin - blood Leptin - blood Lipids - blood Male Middle Aged Original Clinical Resistin - blood Single-Blind Method Triglycerides - blood Xylans - therapeutic use |
| title | Arabinoxylan Fibre Consumption Improved Glucose Metabolism, but did not Affect Serum Adipokines in Subjects with Impaired Glucose Tolerance |
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