HOP/NECC1, A Novel Regulator of Mouse Trophoblast Differentiation
Homeodomain-only protein/not expressed in choriocarcinoma clone 1 (HOP/NECC1) is a newly identified gene that modifies the expression of cardiac-specific genes and thereby regulates heart development. More recently, HOP/NECC1 was reported to be a suppressor of choriocarcinogenesis. Here, we examined...
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| Veröffentlicht in: | The Journal of biological chemistry 2007-08, Vol.282 (33), p.24065-24074 |
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| container_title | The Journal of biological chemistry |
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| creator | Asanoma, Kazuo Kato, Hidenori Yamaguchi, Shinichiro Shin, Chong Hyun Liu, Zhi-Ping Kato, Kiyoko Inoue, Takafumi Miyanari, Yoko Yoshikawa, Koji Sonoda, Kenzo Fukushima, Kotaro Wake, Norio |
| description | Homeodomain-only protein/not expressed in choriocarcinoma clone 1 (HOP/NECC1) is a newly identified gene that modifies the expression of cardiac-specific genes and thereby regulates heart development. More recently, HOP/NECC1 was reported to be a suppressor of choriocarcinogenesis. Here, we examined the temporal expression profile of HOP/NECC1 in wild-type mouse placenta. We found that E8.5–E9.5 wild-type placenta expressed HOP/NECC1 in the giant cell and spongiotrophoblast layers. HOP/NECC1 (-/-) placenta exhibited marked propagation of giant cell layers and, in turn reduction of spongiotrophoblast formation. We demonstrated SRF transcriptional activity increased in the differentiating trophoblasts and forced expression of SRF in a trophoblast stem (TS) cell line induces the differentiation into giant cells. Negative regulation of SRF (serum response factor) by the binding of HOP/NECC1 protein contributed at least in part to the generation of these placental defects. Gradual induction of HOP/NECC1 in response to differentiation stimuli may result in the decision to differentiate into a particular type of trophoblastic cell lineage and result in non-lethal defects shown by the HOP/NECC1 (-/-) placentas. |
| doi_str_mv | 10.1074/jbc.M701380200 |
| format | Article |
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More recently, HOP/NECC1 was reported to be a suppressor of choriocarcinogenesis. Here, we examined the temporal expression profile of HOP/NECC1 in wild-type mouse placenta. We found that E8.5–E9.5 wild-type placenta expressed HOP/NECC1 in the giant cell and spongiotrophoblast layers. HOP/NECC1 (-/-) placenta exhibited marked propagation of giant cell layers and, in turn reduction of spongiotrophoblast formation. We demonstrated SRF transcriptional activity increased in the differentiating trophoblasts and forced expression of SRF in a trophoblast stem (TS) cell line induces the differentiation into giant cells. Negative regulation of SRF (serum response factor) by the binding of HOP/NECC1 protein contributed at least in part to the generation of these placental defects. Gradual induction of HOP/NECC1 in response to differentiation stimuli may result in the decision to differentiate into a particular type of trophoblastic cell lineage and result in non-lethal defects shown by the HOP/NECC1 (-/-) placentas.</description><identifier>ISSN: 0021-9258</identifier><identifier>EISSN: 1083-351X</identifier><identifier>DOI: 10.1074/jbc.M701380200</identifier><identifier>PMID: 17576768</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Animals ; Cell Differentiation ; Cell Lineage ; Female ; Gene Expression Profiling ; Genotype ; Homeodomain Proteins - genetics ; Homeodomain Proteins - physiology ; Humans ; Mice ; Mice, Knockout ; Mice, Transgenic ; Time Factors ; Trophoblasts - cytology ; Tumor Suppressor Proteins - genetics ; Tumor Suppressor Proteins - physiology</subject><ispartof>The Journal of biological chemistry, 2007-08, Vol.282 (33), p.24065-24074</ispartof><rights>2007 © 2007 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c442t-18e352e8a2fa448a358d26bdcde73b06194c8ca6a81a67552ddd2b9d7d06e60d3</citedby><cites>FETCH-LOGICAL-c442t-18e352e8a2fa448a358d26bdcde73b06194c8ca6a81a67552ddd2b9d7d06e60d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17576768$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Asanoma, Kazuo</creatorcontrib><creatorcontrib>Kato, Hidenori</creatorcontrib><creatorcontrib>Yamaguchi, Shinichiro</creatorcontrib><creatorcontrib>Shin, Chong Hyun</creatorcontrib><creatorcontrib>Liu, Zhi-Ping</creatorcontrib><creatorcontrib>Kato, Kiyoko</creatorcontrib><creatorcontrib>Inoue, Takafumi</creatorcontrib><creatorcontrib>Miyanari, Yoko</creatorcontrib><creatorcontrib>Yoshikawa, Koji</creatorcontrib><creatorcontrib>Sonoda, Kenzo</creatorcontrib><creatorcontrib>Fukushima, Kotaro</creatorcontrib><creatorcontrib>Wake, Norio</creatorcontrib><title>HOP/NECC1, A Novel Regulator of Mouse Trophoblast Differentiation</title><title>The Journal of biological chemistry</title><addtitle>J Biol Chem</addtitle><description>Homeodomain-only protein/not expressed in choriocarcinoma clone 1 (HOP/NECC1) is a newly identified gene that modifies the expression of cardiac-specific genes and thereby regulates heart development. More recently, HOP/NECC1 was reported to be a suppressor of choriocarcinogenesis. Here, we examined the temporal expression profile of HOP/NECC1 in wild-type mouse placenta. We found that E8.5–E9.5 wild-type placenta expressed HOP/NECC1 in the giant cell and spongiotrophoblast layers. HOP/NECC1 (-/-) placenta exhibited marked propagation of giant cell layers and, in turn reduction of spongiotrophoblast formation. We demonstrated SRF transcriptional activity increased in the differentiating trophoblasts and forced expression of SRF in a trophoblast stem (TS) cell line induces the differentiation into giant cells. Negative regulation of SRF (serum response factor) by the binding of HOP/NECC1 protein contributed at least in part to the generation of these placental defects. Gradual induction of HOP/NECC1 in response to differentiation stimuli may result in the decision to differentiate into a particular type of trophoblastic cell lineage and result in non-lethal defects shown by the HOP/NECC1 (-/-) placentas.</description><subject>Animals</subject><subject>Cell Differentiation</subject><subject>Cell Lineage</subject><subject>Female</subject><subject>Gene Expression Profiling</subject><subject>Genotype</subject><subject>Homeodomain Proteins - genetics</subject><subject>Homeodomain Proteins - physiology</subject><subject>Humans</subject><subject>Mice</subject><subject>Mice, Knockout</subject><subject>Mice, Transgenic</subject><subject>Time Factors</subject><subject>Trophoblasts - cytology</subject><subject>Tumor Suppressor Proteins - genetics</subject><subject>Tumor Suppressor Proteins - physiology</subject><issn>0021-9258</issn><issn>1083-351X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtLAzEURoMoWh9blzILceXUPGaSzLLUJ1QrUsFdyCR3bGTa1GRa8d8baaEr8W7u5nwf9x6ETgnuEyyKq4_a9B8FJkxiivEO6hEsWc5K8raLehhTkle0lAfoMMYPnKaoyD46IKIUXHDZQ4P78fPV081wSC6zQfbkV9BmL_C-bHXnQ-ab7NEvI2ST4BdTX7c6dtm1axoIMO-c7pyfH6O9RrcRTjb7CL3e3kyG9_lofPcwHIxyUxS0y4kEVlKQmja6KKRmpbSU19ZYEKzGnFSFkUZzLYnmoiyptZbWlRUWc-DYsiN0se5dBP-5hNipmYsG2lbPId2ouCQ8_Sf-BUklmGAUJ7C_Bk3wMQZo1CK4mQ7fimD1a1clu2prNwXONs3LegZ2i290JuB8DUzd-_TLBVC182YKM0UlVYwpWmBeJkyuMUi-Vg6CisbB3IBNEdMp691fJ_wAPzaSIw</recordid><startdate>20070817</startdate><enddate>20070817</enddate><creator>Asanoma, Kazuo</creator><creator>Kato, Hidenori</creator><creator>Yamaguchi, Shinichiro</creator><creator>Shin, Chong Hyun</creator><creator>Liu, Zhi-Ping</creator><creator>Kato, Kiyoko</creator><creator>Inoue, Takafumi</creator><creator>Miyanari, Yoko</creator><creator>Yoshikawa, Koji</creator><creator>Sonoda, Kenzo</creator><creator>Fukushima, Kotaro</creator><creator>Wake, Norio</creator><general>Elsevier Inc</general><general>American Society for Biochemistry and Molecular Biology</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20070817</creationdate><title>HOP/NECC1, A Novel Regulator of Mouse Trophoblast Differentiation</title><author>Asanoma, Kazuo ; Kato, Hidenori ; Yamaguchi, Shinichiro ; Shin, Chong Hyun ; Liu, Zhi-Ping ; Kato, Kiyoko ; Inoue, Takafumi ; Miyanari, Yoko ; Yoshikawa, Koji ; Sonoda, Kenzo ; Fukushima, Kotaro ; Wake, Norio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c442t-18e352e8a2fa448a358d26bdcde73b06194c8ca6a81a67552ddd2b9d7d06e60d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Animals</topic><topic>Cell Differentiation</topic><topic>Cell Lineage</topic><topic>Female</topic><topic>Gene Expression Profiling</topic><topic>Genotype</topic><topic>Homeodomain Proteins - genetics</topic><topic>Homeodomain Proteins - physiology</topic><topic>Humans</topic><topic>Mice</topic><topic>Mice, Knockout</topic><topic>Mice, Transgenic</topic><topic>Time Factors</topic><topic>Trophoblasts - cytology</topic><topic>Tumor Suppressor Proteins - genetics</topic><topic>Tumor Suppressor Proteins - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Asanoma, Kazuo</creatorcontrib><creatorcontrib>Kato, Hidenori</creatorcontrib><creatorcontrib>Yamaguchi, Shinichiro</creatorcontrib><creatorcontrib>Shin, Chong Hyun</creatorcontrib><creatorcontrib>Liu, Zhi-Ping</creatorcontrib><creatorcontrib>Kato, Kiyoko</creatorcontrib><creatorcontrib>Inoue, Takafumi</creatorcontrib><creatorcontrib>Miyanari, Yoko</creatorcontrib><creatorcontrib>Yoshikawa, Koji</creatorcontrib><creatorcontrib>Sonoda, Kenzo</creatorcontrib><creatorcontrib>Fukushima, Kotaro</creatorcontrib><creatorcontrib>Wake, Norio</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of biological chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Asanoma, Kazuo</au><au>Kato, Hidenori</au><au>Yamaguchi, Shinichiro</au><au>Shin, Chong Hyun</au><au>Liu, Zhi-Ping</au><au>Kato, Kiyoko</au><au>Inoue, Takafumi</au><au>Miyanari, Yoko</au><au>Yoshikawa, Koji</au><au>Sonoda, Kenzo</au><au>Fukushima, Kotaro</au><au>Wake, Norio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>HOP/NECC1, A Novel Regulator of Mouse Trophoblast Differentiation</atitle><jtitle>The Journal of biological chemistry</jtitle><addtitle>J Biol Chem</addtitle><date>2007-08-17</date><risdate>2007</risdate><volume>282</volume><issue>33</issue><spage>24065</spage><epage>24074</epage><pages>24065-24074</pages><issn>0021-9258</issn><eissn>1083-351X</eissn><abstract>Homeodomain-only protein/not expressed in choriocarcinoma clone 1 (HOP/NECC1) is a newly identified gene that modifies the expression of cardiac-specific genes and thereby regulates heart development. 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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Animals Cell Differentiation Cell Lineage Female Gene Expression Profiling Genotype Homeodomain Proteins - genetics Homeodomain Proteins - physiology Humans Mice Mice, Knockout Mice, Transgenic Time Factors Trophoblasts - cytology Tumor Suppressor Proteins - genetics Tumor Suppressor Proteins - physiology |
| title | HOP/NECC1, A Novel Regulator of Mouse Trophoblast Differentiation |
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