High proliferative activity and chromosomal instability in oral lichen planus
The study aimed to assess the proliferative activity and karyotype in Oral Lichen Planus (OLP) lesions. G-banding chromosomal analysis of short-term primary cultures, and immunohistochemical expression of Ki67 and p53 were applied in 30 consecutive OLP patients divided into two groups according to c...
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| Veröffentlicht in: | International journal of oral and maxillofacial surgery 2006-12, Vol.35 (12), p.1140-1144 |
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| container_title | International journal of oral and maxillofacial surgery |
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| creator | Montebugnoli, L. Farnedi, A. Marchetti, C. Magrini, E. Pession, A. Foschini, M.P. |
| description | The study aimed to assess the proliferative activity and karyotype in Oral Lichen Planus (OLP) lesions. G-banding chromosomal analysis of short-term primary cultures, and immunohistochemical expression of Ki67 and p53 were applied in 30 consecutive OLP patients divided into two groups according to clinical presentation of the lesions, and in nine subjects as negative controls. Mean values of Ki67 and p53 expression differed significantly (
P
<
.01) between controls and patients groups with reticular or atrophic-erosive forms of OLP, whereas there was no significant difference between the two groups of patients with reticular or atrophic-erosive lesions. Six OLP patients showed clonal chromosome alterations, four of them associated with p53 overexpression.
In conclusion, OLP is characterized by a high cellular turnover in most patients irrespective of clinical disease presentation. The genetic instability found in some patients should be interpreted as a consequence of the enhanced epithelial turnover, although we cannot rule out the possibility that some of the cytogenetic non-random anomalies observed represent early steps in cancer development. |
| doi_str_mv | 10.1016/j.ijom.2006.07.018 |
| format | Article |
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P
<
.01) between controls and patients groups with reticular or atrophic-erosive forms of OLP, whereas there was no significant difference between the two groups of patients with reticular or atrophic-erosive lesions. Six OLP patients showed clonal chromosome alterations, four of them associated with p53 overexpression.
In conclusion, OLP is characterized by a high cellular turnover in most patients irrespective of clinical disease presentation. The genetic instability found in some patients should be interpreted as a consequence of the enhanced epithelial turnover, although we cannot rule out the possibility that some of the cytogenetic non-random anomalies observed represent early steps in cancer development.</description><identifier>ISSN: 0901-5027</identifier><identifier>EISSN: 1399-0020</identifier><identifier>DOI: 10.1016/j.ijom.2006.07.018</identifier><identifier>PMID: 17095190</identifier><identifier>CODEN: IJOSE9</identifier><language>eng</language><publisher>Amsterdam: Elsevier Ltd</publisher><subject>Adult ; Aged ; Biological and medical sciences ; Chromosomal Instability - genetics ; cytogenetic ; Dentistry ; Dermatology ; Epidemiologic Methods ; Female ; Humans ; Karyotyping ; keratinocytes ; Ki-67 Antigen - analysis ; Ki67 ; Lichen Planus, Oral - genetics ; Male ; Medical sciences ; Middle Aged ; oral lichen planus ; Otorhinolaryngology. Stomatology ; p53 ; Psoriasis. Parapsoriasis. Lichen ; Tumor Suppressor Protein p53 - analysis</subject><ispartof>International journal of oral and maxillofacial surgery, 2006-12, Vol.35 (12), p.1140-1144</ispartof><rights>2006 International Association of Oral and Maxillofacial Surgeons</rights><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c384t-e3454c6ff88e2e0e91382ff32240e522f9286b75e0f02e8505a69a4b4bbf41433</citedby><cites>FETCH-LOGICAL-c384t-e3454c6ff88e2e0e91382ff32240e522f9286b75e0f02e8505a69a4b4bbf41433</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ijom.2006.07.018$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,45974</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18303833$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17095190$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Montebugnoli, L.</creatorcontrib><creatorcontrib>Farnedi, A.</creatorcontrib><creatorcontrib>Marchetti, C.</creatorcontrib><creatorcontrib>Magrini, E.</creatorcontrib><creatorcontrib>Pession, A.</creatorcontrib><creatorcontrib>Foschini, M.P.</creatorcontrib><title>High proliferative activity and chromosomal instability in oral lichen planus</title><title>International journal of oral and maxillofacial surgery</title><addtitle>Int J Oral Maxillofac Surg</addtitle><description>The study aimed to assess the proliferative activity and karyotype in Oral Lichen Planus (OLP) lesions. G-banding chromosomal analysis of short-term primary cultures, and immunohistochemical expression of Ki67 and p53 were applied in 30 consecutive OLP patients divided into two groups according to clinical presentation of the lesions, and in nine subjects as negative controls. Mean values of Ki67 and p53 expression differed significantly (
P
<
.01) between controls and patients groups with reticular or atrophic-erosive forms of OLP, whereas there was no significant difference between the two groups of patients with reticular or atrophic-erosive lesions. Six OLP patients showed clonal chromosome alterations, four of them associated with p53 overexpression.
In conclusion, OLP is characterized by a high cellular turnover in most patients irrespective of clinical disease presentation. The genetic instability found in some patients should be interpreted as a consequence of the enhanced epithelial turnover, although we cannot rule out the possibility that some of the cytogenetic non-random anomalies observed represent early steps in cancer development.</description><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Chromosomal Instability - genetics</subject><subject>cytogenetic</subject><subject>Dentistry</subject><subject>Dermatology</subject><subject>Epidemiologic Methods</subject><subject>Female</subject><subject>Humans</subject><subject>Karyotyping</subject><subject>keratinocytes</subject><subject>Ki-67 Antigen - analysis</subject><subject>Ki67</subject><subject>Lichen Planus, Oral - genetics</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>oral lichen planus</subject><subject>Otorhinolaryngology. Stomatology</subject><subject>p53</subject><subject>Psoriasis. Parapsoriasis. Lichen</subject><subject>Tumor Suppressor Protein p53 - analysis</subject><issn>0901-5027</issn><issn>1399-0020</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LxDAQhoMouq7-AQ_Si95aJ0k_EvAi4hcoXvQc0uzEzdI2a9IV9t-bsgvePA3MPO_w8hByQaGgQOubVeFWvi8YQF1AUwAVB2RGuZQ5AINDMgMJNK-ANSfkNMYVAEgummNyQhuQFZUwI2_P7muZrYPvnMWgR_eDmTZpuHGb6WGRmWXwvY--113mhjjq1nXTzQ2ZD2nXObPEIVt3etjEM3JkdRfxfD_n5PPx4eP-OX99f3q5v3vNDRflmCMvq9LU1gqBDAEl5YJZyxkrASvGrGSibpsKwQJDUUGla6nLtmxbW9KS8zm53v1Nxb83GEfVu2iwSyXQb6KqBa2kYDSBbAea4GMMaNU6uF6HraKgJolqpSaJapKooFFJYgpd7r9v2h4Xf5G9tQRc7QEdje5s0INx8Y8THLjgU83bHYfJxY_DoKJxOBhcuIBmVAvv_uvxC9HpkB8</recordid><startdate>20061201</startdate><enddate>20061201</enddate><creator>Montebugnoli, L.</creator><creator>Farnedi, A.</creator><creator>Marchetti, C.</creator><creator>Magrini, E.</creator><creator>Pession, A.</creator><creator>Foschini, M.P.</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20061201</creationdate><title>High proliferative activity and chromosomal instability in oral lichen planus</title><author>Montebugnoli, L. ; Farnedi, A. ; Marchetti, C. ; Magrini, E. ; Pession, A. ; Foschini, M.P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c384t-e3454c6ff88e2e0e91382ff32240e522f9286b75e0f02e8505a69a4b4bbf41433</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Chromosomal Instability - genetics</topic><topic>cytogenetic</topic><topic>Dentistry</topic><topic>Dermatology</topic><topic>Epidemiologic Methods</topic><topic>Female</topic><topic>Humans</topic><topic>Karyotyping</topic><topic>keratinocytes</topic><topic>Ki-67 Antigen - analysis</topic><topic>Ki67</topic><topic>Lichen Planus, Oral - genetics</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>oral lichen planus</topic><topic>Otorhinolaryngology. Stomatology</topic><topic>p53</topic><topic>Psoriasis. Parapsoriasis. Lichen</topic><topic>Tumor Suppressor Protein p53 - analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Montebugnoli, L.</creatorcontrib><creatorcontrib>Farnedi, A.</creatorcontrib><creatorcontrib>Marchetti, C.</creatorcontrib><creatorcontrib>Magrini, E.</creatorcontrib><creatorcontrib>Pession, A.</creatorcontrib><creatorcontrib>Foschini, M.P.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of oral and maxillofacial surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Montebugnoli, L.</au><au>Farnedi, A.</au><au>Marchetti, C.</au><au>Magrini, E.</au><au>Pession, A.</au><au>Foschini, M.P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>High proliferative activity and chromosomal instability in oral lichen planus</atitle><jtitle>International journal of oral and maxillofacial surgery</jtitle><addtitle>Int J Oral Maxillofac Surg</addtitle><date>2006-12-01</date><risdate>2006</risdate><volume>35</volume><issue>12</issue><spage>1140</spage><epage>1144</epage><pages>1140-1144</pages><issn>0901-5027</issn><eissn>1399-0020</eissn><coden>IJOSE9</coden><abstract>The study aimed to assess the proliferative activity and karyotype in Oral Lichen Planus (OLP) lesions. G-banding chromosomal analysis of short-term primary cultures, and immunohistochemical expression of Ki67 and p53 were applied in 30 consecutive OLP patients divided into two groups according to clinical presentation of the lesions, and in nine subjects as negative controls. Mean values of Ki67 and p53 expression differed significantly (
P
<
.01) between controls and patients groups with reticular or atrophic-erosive forms of OLP, whereas there was no significant difference between the two groups of patients with reticular or atrophic-erosive lesions. Six OLP patients showed clonal chromosome alterations, four of them associated with p53 overexpression.
In conclusion, OLP is characterized by a high cellular turnover in most patients irrespective of clinical disease presentation. The genetic instability found in some patients should be interpreted as a consequence of the enhanced epithelial turnover, although we cannot rule out the possibility that some of the cytogenetic non-random anomalies observed represent early steps in cancer development.</abstract><cop>Amsterdam</cop><pub>Elsevier Ltd</pub><pmid>17095190</pmid><doi>10.1016/j.ijom.2006.07.018</doi><tpages>5</tpages></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adult Aged Biological and medical sciences Chromosomal Instability - genetics cytogenetic Dentistry Dermatology Epidemiologic Methods Female Humans Karyotyping keratinocytes Ki-67 Antigen - analysis Ki67 Lichen Planus, Oral - genetics Male Medical sciences Middle Aged oral lichen planus Otorhinolaryngology. Stomatology p53 Psoriasis. Parapsoriasis. Lichen Tumor Suppressor Protein p53 - analysis |
| title | High proliferative activity and chromosomal instability in oral lichen planus |
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