Precise destruction: an emerging picture of the APC
Cell cycle transitions are often accompanied by the degradation of regulatory molecules. Targeting proteins to the proteasome for degradation is accomplished by the covalent addition of ubiquitin chains. The specificity of this pathway is largely dictated by a set of enzymes called ubiquitin ligases...
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| Veröffentlicht in: | Genes & development 2006-11, Vol.20 (22), p.3069-3078 |
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| container_title | Genes & development |
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| creator | Thornton, Brian R Toczyski, David P |
| description | Cell cycle transitions are often accompanied by the degradation of regulatory molecules. Targeting proteins to the proteasome for degradation is accomplished by the covalent addition of ubiquitin chains. The specificity of this pathway is largely dictated by a set of enzymes called ubiquitin ligases (or E3s). The anaphase-promoting complex (or APC) is a ubiquitin ligase that has a particularly prominent role in regulating cell cycle progression. To date, the APC is the most complicated member of the RING/cullin family of multisubunit E3s. It includes at least 13 core subunits and three related adaptors. A combination of biochemical, genetic, and structural approaches are now shedding light on the enzymology of the APC. This review will focus on these data, drawing parallels with related ubiquitin ligases. |
| doi_str_mv | 10.1101/gad.1478306 |
| format | Article |
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| ispartof | Genes & development, 2006-11, Vol.20 (22), p.3069-3078 |
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| language | eng |
| recordid | cdi_proquest_miscellaneous_68159587 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Anaphase-Promoting Complex-Cyclosome Cell Cycle Cullin Proteins - metabolism Humans Protein Structure, Tertiary Protein Subunits - metabolism Repetitive Sequences, Amino Acid Ubiquitin-Protein Ligase Complexes - chemistry Ubiquitin-Protein Ligase Complexes - metabolism |
| title | Precise destruction: an emerging picture of the APC |
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