Is Panton‐Valentine Leukocidin the Major Virulence Determinant in Community‐Associated Methicillin‐Resistant Staphylococcus aureus Disease?

Methicillin‐resistant Staphylococcus aureus (MRSA) remains a major problem in hospitals, and it is now spreading in the community. A single toxin, Panton‐Valentine leukocidin (PVL), has been linked by epidemiological studies to community‐associated MRSA (CA‐MRSA) disease. However, the role that PVL...

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Veröffentlicht in:	The Journal of infectious diseases 2006-12, Vol.194 (12), p.1761-1770
Hauptverfasser:	Voyich, Jovanka M. , Otto, Michael , Mathema, Barun , Braughton, Kevin R. , Whitney, Adeline R. , Welty, Diane , Long, R. Daniel , Dorward, David W. , Gardner, Donald J. , Lina, Gérard , Kreiswirth, Barry N. , DeLeo, Frank R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Abscess - microbiology Abscesses Animals Animals, Outbred Strains Bacteria Bacterial Toxins - genetics Bacterial Toxins - metabolism Bacteriology Biological and medical sciences Epidemiology Exotoxins - genetics Exotoxins - metabolism Exotoxins - physiology Female Fundamental and applied biological sciences. Psychology Humans Immunocompetence Infections Infectious diseases Leukocidins Leukocidins - genetics Leukocidins - metabolism Leukocidins - physiology Leukocytes, Mononuclear - microbiology Medical sciences Methicillin - pharmacology Methicillin Resistance Mice Mice, Hairless Microbiology Miscellaneous Neutrophils Neutrophils - microbiology Pathogenesis Point Mutation Sepsis Sepsis - microbiology Staphylococcal Infections - microbiology Staphylococcus aureus Staphylococcus aureus - drug effects Staphylococcus aureus - growth & development Staphylococcus aureus - metabolism Staphylococcus aureus - pathogenicity Virulence
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