Proposed new score predicting malignancy of intraductal papillary mucinous neoplasms of the pancreas
Abstract Background Our objective was to predict malignancy for intraductal papillary mucinous neoplasms of the pancreas (IPMN) before operation. Methods Sixty-four resected patients with IPMN were examined and 17 parameters were investigated for their relation to malignancy by univariate and multiv...
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| Veröffentlicht in: | The American journal of surgery 2007-09, Vol.194 (3), p.304-307 |
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| creator | Fujino, Yasuhiro, M.D., Ph.D Matsumoto, Ippei, M.D., Ph.D Ueda, Takashi, M.D., Ph.D Toyama, Hirotika, M.D., Ph.D Kuroda, Yoshikazu, M.D., Ph.D |
| description | Abstract Background Our objective was to predict malignancy for intraductal papillary mucinous neoplasms of the pancreas (IPMN) before operation. Methods Sixty-four resected patients with IPMN were examined and 17 parameters were investigated for their relation to malignancy by univariate and multivariate analysis. Results Multivariate logistic regression analysis showed that IPMN type, the size of main pancreatic duct, and serum carbohydrate antigen 19-9 were significant for malignancy. Size of the main pancreatic duct ≥6.5 mm and serum carbohydrate antigen 19-9 ≥35 U/mL scored 3 points, main duct type scored 2 points, and patulous papilla, jaundice, diabetes mellitus, and tumor size ≥42 mm scored 1 point. When IPMNs with 3 and more than 3 points using the new score were diagnosed as malignant, accuracy was 90.6%. Conclusion This scoring system for IPMN is feasible to detect malignancy and useful for selecting an appropriate treatment. |
| doi_str_mv | 10.1016/j.amjsurg.2006.11.038 |
| format | Article |
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Methods Sixty-four resected patients with IPMN were examined and 17 parameters were investigated for their relation to malignancy by univariate and multivariate analysis. Results Multivariate logistic regression analysis showed that IPMN type, the size of main pancreatic duct, and serum carbohydrate antigen 19-9 were significant for malignancy. Size of the main pancreatic duct ≥6.5 mm and serum carbohydrate antigen 19-9 ≥35 U/mL scored 3 points, main duct type scored 2 points, and patulous papilla, jaundice, diabetes mellitus, and tumor size ≥42 mm scored 1 point. When IPMNs with 3 and more than 3 points using the new score were diagnosed as malignant, accuracy was 90.6%. Conclusion This scoring system for IPMN is feasible to detect malignancy and useful for selecting an appropriate treatment.</description><identifier>ISSN: 0002-9610</identifier><identifier>EISSN: 1879-1883</identifier><identifier>DOI: 10.1016/j.amjsurg.2006.11.038</identifier><identifier>PMID: 17693271</identifier><identifier>CODEN: AJSUAB</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Abdomen ; Adenocarcinoma, Mucinous - pathology ; Adult ; Age ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Carcinoma, Papillary - pathology ; Confidence intervals ; Cysts ; Female ; Gastroenterology. Liver. Pancreas. Abdomen ; Gender ; General aspects ; Humans ; Intraductal papillary mucinous neoplasms of the pancreas ; Liver. Biliary tract. Portal circulation. Exocrine pancreas ; Male ; Malignancy ; Medical sciences ; Middle Aged ; Multivariate analysis ; Pain ; Pancreas ; Pancreatic cancer ; Pancreatic Neoplasms - pathology ; Predictive Value of Tests ; Score ; Surgery ; Tumors ; Variables</subject><ispartof>The American journal of surgery, 2007-09, Vol.194 (3), p.304-307</ispartof><rights>Excerpta Medica Inc.</rights><rights>2007 Excerpta Medica Inc.</rights><rights>2007 INIST-CNRS</rights><rights>Copyright Elsevier Limited Sep 2007</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c542t-dede9efa2fb973c1e084d344557b9543add84942e4f2e5d87655fca605291abe3</citedby><cites>FETCH-LOGICAL-c542t-dede9efa2fb973c1e084d344557b9543add84942e4f2e5d87655fca605291abe3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0002961007004485$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19009580$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17693271$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fujino, Yasuhiro, M.D., Ph.D</creatorcontrib><creatorcontrib>Matsumoto, Ippei, M.D., Ph.D</creatorcontrib><creatorcontrib>Ueda, Takashi, M.D., Ph.D</creatorcontrib><creatorcontrib>Toyama, Hirotika, M.D., Ph.D</creatorcontrib><creatorcontrib>Kuroda, Yoshikazu, M.D., Ph.D</creatorcontrib><title>Proposed new score predicting malignancy of intraductal papillary mucinous neoplasms of the pancreas</title><title>The American journal of surgery</title><addtitle>Am J Surg</addtitle><description>Abstract Background Our objective was to predict malignancy for intraductal papillary mucinous neoplasms of the pancreas (IPMN) before operation. Methods Sixty-four resected patients with IPMN were examined and 17 parameters were investigated for their relation to malignancy by univariate and multivariate analysis. Results Multivariate logistic regression analysis showed that IPMN type, the size of main pancreatic duct, and serum carbohydrate antigen 19-9 were significant for malignancy. Size of the main pancreatic duct ≥6.5 mm and serum carbohydrate antigen 19-9 ≥35 U/mL scored 3 points, main duct type scored 2 points, and patulous papilla, jaundice, diabetes mellitus, and tumor size ≥42 mm scored 1 point. When IPMNs with 3 and more than 3 points using the new score were diagnosed as malignant, accuracy was 90.6%. Conclusion This scoring system for IPMN is feasible to detect malignancy and useful for selecting an appropriate treatment.</description><subject>Abdomen</subject><subject>Adenocarcinoma, Mucinous - pathology</subject><subject>Adult</subject><subject>Age</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Carcinoma, Papillary - pathology</subject><subject>Confidence intervals</subject><subject>Cysts</subject><subject>Female</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Gender</subject><subject>General aspects</subject><subject>Humans</subject><subject>Intraductal papillary mucinous neoplasms of the pancreas</subject><subject>Liver. Biliary tract. Portal circulation. Exocrine pancreas</subject><subject>Male</subject><subject>Malignancy</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Multivariate analysis</subject><subject>Pain</subject><subject>Pancreas</subject><subject>Pancreatic cancer</subject><subject>Pancreatic Neoplasms - pathology</subject><subject>Predictive Value of Tests</subject><subject>Score</subject><subject>Surgery</subject><subject>Tumors</subject><subject>Variables</subject><issn>0002-9610</issn><issn>1879-1883</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkl-r1DAQxYMo3vXqR1AKom9dM2nSJi9e5OI_uKCgPodsMl1T26YmrbLf3pQtLNwXn0LgN2fOzBlCngPdA4X6Tbc3Q5eWeNwzSus9wJ5W8gHZgWxUCVJWD8mOUspKVQO9Ik9S6vIXgFePyRU0tapYAzvivsYwhYSuGPFvkWyIWEwRnbezH4_FYHp_HM1oT0VoCz_O0bjFzqYvJjP5vjfxVAyL9WNYUlYIU2_SkFZ2_pmFcmFEk56SR63pEz7b3mvy48P777efyrsvHz_fvrsrreBsLh06VNga1h5UU1lAKrmrOBeiOSjBK-Oc5Ioz5C1D4WRTC9FaU1PBFJgDVtfk9Vl3iuH3gmnWg08Ws81sbUm6liAkMMjgy3tgF5Y4Zm8aeG4oa07rTIkzZWNIKWKrp-iHPLIGqtcQdKe3EPQaggbQOYRc92JTXw4DukvVtvUMvNoAk6zp25j35NOFU5QqIWnmbs4c5qX98Rh1sh5Hm-OJaGftgv-vlbf3FGzvR5-b_sITpsvUOjFN9bf1YtaDoQ2lnEtR_QNUj74y</recordid><startdate>20070901</startdate><enddate>20070901</enddate><creator>Fujino, Yasuhiro, M.D., Ph.D</creator><creator>Matsumoto, Ippei, M.D., Ph.D</creator><creator>Ueda, Takashi, M.D., Ph.D</creator><creator>Toyama, Hirotika, M.D., Ph.D</creator><creator>Kuroda, Yoshikazu, M.D., Ph.D</creator><general>Elsevier Inc</general><general>Elsevier</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20070901</creationdate><title>Proposed new score predicting malignancy of intraductal papillary mucinous neoplasms of the pancreas</title><author>Fujino, Yasuhiro, M.D., Ph.D ; Matsumoto, Ippei, M.D., Ph.D ; Ueda, Takashi, M.D., Ph.D ; Toyama, Hirotika, M.D., Ph.D ; Kuroda, Yoshikazu, M.D., Ph.D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c542t-dede9efa2fb973c1e084d344557b9543add84942e4f2e5d87655fca605291abe3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Abdomen</topic><topic>Adenocarcinoma, Mucinous - pathology</topic><topic>Adult</topic><topic>Age</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Carcinoma, Papillary - pathology</topic><topic>Confidence intervals</topic><topic>Cysts</topic><topic>Female</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Gender</topic><topic>General aspects</topic><topic>Humans</topic><topic>Intraductal papillary mucinous neoplasms of the pancreas</topic><topic>Liver. Biliary tract. Portal circulation. Exocrine pancreas</topic><topic>Male</topic><topic>Malignancy</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Multivariate analysis</topic><topic>Pain</topic><topic>Pancreas</topic><topic>Pancreatic cancer</topic><topic>Pancreatic Neoplasms - pathology</topic><topic>Predictive Value of Tests</topic><topic>Score</topic><topic>Surgery</topic><topic>Tumors</topic><topic>Variables</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fujino, Yasuhiro, M.D., Ph.D</creatorcontrib><creatorcontrib>Matsumoto, Ippei, M.D., Ph.D</creatorcontrib><creatorcontrib>Ueda, Takashi, M.D., Ph.D</creatorcontrib><creatorcontrib>Toyama, Hirotika, M.D., Ph.D</creatorcontrib><creatorcontrib>Kuroda, Yoshikazu, M.D., Ph.D</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fujino, Yasuhiro, M.D., Ph.D</au><au>Matsumoto, Ippei, M.D., Ph.D</au><au>Ueda, Takashi, M.D., Ph.D</au><au>Toyama, Hirotika, M.D., Ph.D</au><au>Kuroda, Yoshikazu, M.D., Ph.D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Proposed new score predicting malignancy of intraductal papillary mucinous neoplasms of the pancreas</atitle><jtitle>The American journal of surgery</jtitle><addtitle>Am J Surg</addtitle><date>2007-09-01</date><risdate>2007</risdate><volume>194</volume><issue>3</issue><spage>304</spage><epage>307</epage><pages>304-307</pages><issn>0002-9610</issn><eissn>1879-1883</eissn><coden>AJSUAB</coden><abstract>Abstract Background Our objective was to predict malignancy for intraductal papillary mucinous neoplasms of the pancreas (IPMN) before operation. Methods Sixty-four resected patients with IPMN were examined and 17 parameters were investigated for their relation to malignancy by univariate and multivariate analysis. Results Multivariate logistic regression analysis showed that IPMN type, the size of main pancreatic duct, and serum carbohydrate antigen 19-9 were significant for malignancy. Size of the main pancreatic duct ≥6.5 mm and serum carbohydrate antigen 19-9 ≥35 U/mL scored 3 points, main duct type scored 2 points, and patulous papilla, jaundice, diabetes mellitus, and tumor size ≥42 mm scored 1 point. When IPMNs with 3 and more than 3 points using the new score were diagnosed as malignant, accuracy was 90.6%. Conclusion This scoring system for IPMN is feasible to detect malignancy and useful for selecting an appropriate treatment.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>17693271</pmid><doi>10.1016/j.amjsurg.2006.11.038</doi><tpages>4</tpages></addata></record> |
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| subjects | Abdomen Adenocarcinoma, Mucinous - pathology Adult Age Aged Aged, 80 and over Biological and medical sciences Carcinoma, Papillary - pathology Confidence intervals Cysts Female Gastroenterology. Liver. Pancreas. Abdomen Gender General aspects Humans Intraductal papillary mucinous neoplasms of the pancreas Liver. Biliary tract. Portal circulation. Exocrine pancreas Male Malignancy Medical sciences Middle Aged Multivariate analysis Pain Pancreas Pancreatic cancer Pancreatic Neoplasms - pathology Predictive Value of Tests Score Surgery Tumors Variables |
| title | Proposed new score predicting malignancy of intraductal papillary mucinous neoplasms of the pancreas |
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