Investigations of the Antibacterial Properties of Ciprofloxacin@SiO2
The antibacterial activity of ciprofloxacin-encapsulated silica nanoshells synthesized from gold@silica core−shell nanoparticles has been investigated. The minimum inhibitory concentration of the material was found using the agar dilution method, and it showed better antibacterial activity compared...
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| Veröffentlicht in: | Langmuir 2006-11, Vol.22 (24), p.10125-10129 |
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| creator | Rosemary, M. J MacLaren, Ian Pradeep, T |
| description | The antibacterial activity of ciprofloxacin-encapsulated silica nanoshells synthesized from gold@silica core−shell nanoparticles has been investigated. The minimum inhibitory concentration of the material was found using the agar dilution method, and it showed better antibacterial activity compared to free ciprofloxacin in the case of Escherichia coli DH5α, whereas the same activity was found for Lactococcus lactis MG 1363. Hydrophobicity measurements carried out in an octanol−water mixture suggested that ciprofloxacin@SiO2 is distributed almost equally in the aqueous and nonaqueous phases. The kinetics of the uptake of ciprofloxacin@SiO2 was compared with that of free ciprofloxacin. Fluorescence imaging studies carried out using fluorescein isothiocyanate@SiO2 showed that the nanoshells enter the bacterial cell. The uptake of silica shells has been probed by transmission electron microscopy also. |
| doi_str_mv | 10.1021/la061411h |
| format | Article |
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The uptake of silica shells has been probed by transmission electron microscopy also.</description><identifier>ISSN: 0743-7463</identifier><identifier>EISSN: 1520-5827</identifier><identifier>DOI: 10.1021/la061411h</identifier><identifier>PMID: 17107009</identifier><identifier>CODEN: LANGD5</identifier><language>eng</language><publisher>Washington, DC: American Chemical Society</publisher><subject>Anti-Bacterial Agents - chemistry ; Anti-Bacterial Agents - pharmacology ; Chemistry ; Ciprofloxacin - chemistry ; Ciprofloxacin - pharmacology ; Colloidal state and disperse state ; Drug Evaluation, Preclinical - methods ; Escherichia coli - metabolism ; Exact sciences and technology ; Fluorescein-5-isothiocyanate - pharmacology ; General and physical chemistry ; Kinetics ; Lactococcus lactis - metabolism ; Microscopy, Electron, Transmission ; Nanoparticles - chemistry ; Octanols - chemistry ; Physical and chemical studies. Granulometry. Electrokinetic phenomena ; Quinolones - chemistry ; Silicon Dioxide - chemistry ; Silicon Dioxide - pharmacology ; Ultraviolet Rays ; Water - chemistry</subject><ispartof>Langmuir, 2006-11, Vol.22 (24), p.10125-10129</ispartof><rights>Copyright © 2006 American Chemical Society</rights><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/la061411h$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/la061411h$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>314,776,780,27053,27901,27902,56713,56763</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18294566$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17107009$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rosemary, M. J</creatorcontrib><creatorcontrib>MacLaren, Ian</creatorcontrib><creatorcontrib>Pradeep, T</creatorcontrib><title>Investigations of the Antibacterial Properties of Ciprofloxacin@SiO2</title><title>Langmuir</title><addtitle>Langmuir</addtitle><description>The antibacterial activity of ciprofloxacin-encapsulated silica nanoshells synthesized from gold@silica core−shell nanoparticles has been investigated. The minimum inhibitory concentration of the material was found using the agar dilution method, and it showed better antibacterial activity compared to free ciprofloxacin in the case of Escherichia coli DH5α, whereas the same activity was found for Lactococcus lactis MG 1363. Hydrophobicity measurements carried out in an octanol−water mixture suggested that ciprofloxacin@SiO2 is distributed almost equally in the aqueous and nonaqueous phases. The kinetics of the uptake of ciprofloxacin@SiO2 was compared with that of free ciprofloxacin. Fluorescence imaging studies carried out using fluorescein isothiocyanate@SiO2 showed that the nanoshells enter the bacterial cell. The uptake of silica shells has been probed by transmission electron microscopy also.</description><subject>Anti-Bacterial Agents - chemistry</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Chemistry</subject><subject>Ciprofloxacin - chemistry</subject><subject>Ciprofloxacin - pharmacology</subject><subject>Colloidal state and disperse state</subject><subject>Drug Evaluation, Preclinical - methods</subject><subject>Escherichia coli - metabolism</subject><subject>Exact sciences and technology</subject><subject>Fluorescein-5-isothiocyanate - pharmacology</subject><subject>General and physical chemistry</subject><subject>Kinetics</subject><subject>Lactococcus lactis - metabolism</subject><subject>Microscopy, Electron, Transmission</subject><subject>Nanoparticles - chemistry</subject><subject>Octanols - chemistry</subject><subject>Physical and chemical studies. Granulometry. Electrokinetic phenomena</subject><subject>Quinolones - chemistry</subject><subject>Silicon Dioxide - chemistry</subject><subject>Silicon Dioxide - pharmacology</subject><subject>Ultraviolet Rays</subject><subject>Water - chemistry</subject><issn>0743-7463</issn><issn>1520-5827</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkV1PwjAUhhujEUQv_ANmN3o37ce6rnfi8IMEhQQSvWu6rpXi2LDdDP57pyCac3Fy8j55zxcApwheIojRVSFhjCKE5nugiyiGIU0w2wddyCISsigmHXDk_QJCyEnED0EHMQRZW3XBYFh-aF_bV1nbqvRBZYJ6roN-WdtMqlo7K4tg4qqVdrXVP3pqV64yRbWWypbXUzvGx-DAyMLrk23ugdnd7Sx9CEfj-2HaH4USE1aHCEONIVWR4Ya2kUiFkFI600zn2JjIEJ5AnuSaMxzHOuEmo1kCVW4kJ5j0wMXGtu3_3rRTi6X1SheFLHXVeBEniDJMYAuebcEmW-pcrJxdSvcpftdugfMtIL2ShXGyVNb_cQnmEY3jlgs3nPW1Xu906d5EzAijYjaZiucbmr48DR7FP1-pvFhUjSvbcwgExfebxO5N5AsJeoEZ</recordid><startdate>20061121</startdate><enddate>20061121</enddate><creator>Rosemary, M. J</creator><creator>MacLaren, Ian</creator><creator>Pradeep, T</creator><general>American Chemical Society</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20061121</creationdate><title>Investigations of the Antibacterial Properties of Ciprofloxacin@SiO2</title><author>Rosemary, M. J ; MacLaren, Ian ; Pradeep, T</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a237t-120e205c4f9f5f5f8ac11ccebe7ed2ff4f398098de97266e89fb5b80cdfa9323</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Anti-Bacterial Agents - chemistry</topic><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Chemistry</topic><topic>Ciprofloxacin - chemistry</topic><topic>Ciprofloxacin - pharmacology</topic><topic>Colloidal state and disperse state</topic><topic>Drug Evaluation, Preclinical - methods</topic><topic>Escherichia coli - metabolism</topic><topic>Exact sciences and technology</topic><topic>Fluorescein-5-isothiocyanate - pharmacology</topic><topic>General and physical chemistry</topic><topic>Kinetics</topic><topic>Lactococcus lactis - metabolism</topic><topic>Microscopy, Electron, Transmission</topic><topic>Nanoparticles - chemistry</topic><topic>Octanols - chemistry</topic><topic>Physical and chemical studies. Granulometry. Electrokinetic phenomena</topic><topic>Quinolones - chemistry</topic><topic>Silicon Dioxide - chemistry</topic><topic>Silicon Dioxide - pharmacology</topic><topic>Ultraviolet Rays</topic><topic>Water - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rosemary, M. J</creatorcontrib><creatorcontrib>MacLaren, Ian</creatorcontrib><creatorcontrib>Pradeep, T</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Langmuir</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rosemary, M. J</au><au>MacLaren, Ian</au><au>Pradeep, T</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Investigations of the Antibacterial Properties of Ciprofloxacin@SiO2</atitle><jtitle>Langmuir</jtitle><addtitle>Langmuir</addtitle><date>2006-11-21</date><risdate>2006</risdate><volume>22</volume><issue>24</issue><spage>10125</spage><epage>10129</epage><pages>10125-10129</pages><issn>0743-7463</issn><eissn>1520-5827</eissn><coden>LANGD5</coden><abstract>The antibacterial activity of ciprofloxacin-encapsulated silica nanoshells synthesized from gold@silica core−shell nanoparticles has been investigated. The minimum inhibitory concentration of the material was found using the agar dilution method, and it showed better antibacterial activity compared to free ciprofloxacin in the case of Escherichia coli DH5α, whereas the same activity was found for Lactococcus lactis MG 1363. Hydrophobicity measurements carried out in an octanol−water mixture suggested that ciprofloxacin@SiO2 is distributed almost equally in the aqueous and nonaqueous phases. The kinetics of the uptake of ciprofloxacin@SiO2 was compared with that of free ciprofloxacin. Fluorescence imaging studies carried out using fluorescein isothiocyanate@SiO2 showed that the nanoshells enter the bacterial cell. The uptake of silica shells has been probed by transmission electron microscopy also.</abstract><cop>Washington, DC</cop><pub>American Chemical Society</pub><pmid>17107009</pmid><doi>10.1021/la061411h</doi><tpages>5</tpages></addata></record> |
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| subjects | Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Chemistry Ciprofloxacin - chemistry Ciprofloxacin - pharmacology Colloidal state and disperse state Drug Evaluation, Preclinical - methods Escherichia coli - metabolism Exact sciences and technology Fluorescein-5-isothiocyanate - pharmacology General and physical chemistry Kinetics Lactococcus lactis - metabolism Microscopy, Electron, Transmission Nanoparticles - chemistry Octanols - chemistry Physical and chemical studies. Granulometry. Electrokinetic phenomena Quinolones - chemistry Silicon Dioxide - chemistry Silicon Dioxide - pharmacology Ultraviolet Rays Water - chemistry |
| title | Investigations of the Antibacterial Properties of Ciprofloxacin@SiO2 |
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