Reduction of dominant or submissive behaviors as models for antimanic or antidepressant drug testing: Technical considerations

Technical variants of mania and depression models that were based on dominant–submissive relationships (DSR) have been analyzed and compared in the present paper. In these paradigms, one animal of a pair developed the behavioral trait of dominance while the other submissiveness in a food competition...

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Veröffentlicht in:	Journal of neuroscience methods 2007-09, Vol.165 (2), p.175-182
Hauptverfasser:	Malatynska, Ewa, Pinhasov, Albert, Crooke, Jeffrey J., Smith-Swintosky, Virginia L., Brenneman, Douglas E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals Antidepressants Antidepressive Agents - pharmacology Antimanic Agents - pharmacology Antimanic drugs Behavior, Animal - drug effects Behavior, Animal - physiology Bipolar Disorder - drug therapy Bipolar Disorder - physiopathology Bipolar Disorder - psychology Competition tests Data Interpretation, Statistical Depression Depressive Disorder - drug therapy Depressive Disorder - physiopathology Depressive Disorder - psychology Disease Models, Animal Dominance-Subordination Dominant–submissive relationships Drug Evaluation, Preclinical - methods Feeding Behavior - physiology Fluoxetine - pharmacology Mania Neuropsychological Tests - standards Rats Rats, Sprague-Dawley Rats, Wistar Reduction of dominant behavior model Reduction of submissive behavior model Serotonin Uptake Inhibitors - pharmacology Social Behavior Valproic Acid - pharmacology Videotape Recording - methods
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