Langerhans Cells Release Prostaglandin D2 in Response to Nicotinic Acid

Nicotinic acid, used for atherosclerosis treatment, has an adverse effect of skin flushing. The flushing mechanism, thought to be caused by the release of prostaglandin D2 (PGD2), is not well understood. We aimed to identify which cells mediate the flushing effect. Nicotinic acid receptor (GPR109A)...

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Veröffentlicht in:	Journal of investigative dermatology 2006-12, Vol.126 (12), p.2637-2646
Hauptverfasser:	Maciejewski-Lenoir, Dominique, Richman, Jeremy G., Hakak, Yaron, Gaidarov, Ibragim, Behan, Dominic P., Connolly, Daniel T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cells, Cultured Dermatology Flushing - chemically induced Humans Hypolipidemic Agents - pharmacology In Vitro Techniques Langerhans Cells - drug effects Langerhans Cells - metabolism Male Medical sciences Mice Mice, Inbred C57BL Niacin - pharmacology Oligonucleotide Array Sequence Analysis Prostaglandin D2 - metabolism Receptors, G-Protein-Coupled - genetics Receptors, G-Protein-Coupled - metabolism Receptors, Nicotinic - genetics Receptors, Nicotinic - metabolism RNA, Messenger - metabolism Skin - metabolism Tissue Distribution
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